Title:
SOFT IONIZATION SYSTEM AND METHOD OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/214718
Kind Code:
A3
Abstract:
Methods and systems are provided for ionizing molecules for the purpose of analysis by mass spectrometry, in which gaseous material from a sample substrate is generated using laser desorption. The laser is provided having a pulse range of about 1-1000 picoseconds to produce the gaseous material. The gaseous material is heated to generate ions from the molecules present in the gaseous material where the amount of heat that is applied is in the temperature range of 45 °C to 250 °C and the applied heat results in soft ionization of the molecules. The ionized molecules are transported to a mass spectrometer for analysis.
Inventors:
ZARRINE AFSAR ARASH (CA)
GINSBERG HOWARD JOESEPH (CA)
WOOLMAN MICHAEL (CA)
GINSBERG HOWARD JOESEPH (CA)
WOOLMAN MICHAEL (CA)
Application Number:
PCT/CA2017/050713
Publication Date:
February 08, 2018
Filing Date:
June 09, 2017
Export Citation:
Assignee:
UNIV HEALTH NETWORK (CA)
ST MICHAELS HOSPITAL (CA)
ST MICHAELS HOSPITAL (CA)
International Classes:
H01J49/10; H01J27/24; H01J49/04
Foreign References:
| US20100213367A1 | 2010-08-26 | |||
| US20150325422A1 | 2015-11-12 | |||
| US9287100B2 | 2016-03-15 | |||
| US20080128608A1 | 2008-06-05 | |||
| US6504150B1 | 2003-01-07 |
Other References:
See also references of EP 3469623A4
Attorney, Agent or Firm:
BERESKIN & PARR LLP/S.E.N.C.R.L.,S.R.L. (CA)
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