SOLID ANTACID AND PROCESS FOR PRODUCING THE SAME

WIPO Patent Application WO/1995/033469

A1

A pharmaceutical composition useful for providing a solid antacid which has the effect of rapidly neutralizing acidity without unnecessarily enhancing the initial pH immediately after administration, is excellent in the effect of persistence of the optimum pH, and exhibits an excellent antacid effect based on the above effects. The composition contains as the active ingredient a combination of a lowly neutralizing antacid (one having an initial pH of less than 6 when tested by the modified Fuchs method using 30 ml of 0.05 N hydrochloric acid and a single dose of the sample, e.g. dry aluminum hydroxide gel) and a highly neutralizing antacid (one having an initial pH of 6 or above when tested similarly, e.g. magnesium hydroxide) coated with a pH-independent water-insoluble macromolecular base (e.g. aqueous ethylcellulose dispersion).

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SHIOZAWA HIROYOSHI (JP)
HASHIMOTO YOSHIMI (JP)
TSUSHIMA KEIKO (JP)
SETOGUCHI YOICHI (JP)

PCT/JP1995/001094

December 14, 1995

June 05, 1995

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YAMANOUCHI PHARMA CO LTD (JP)
SHIOZAWA HIROYOSHI (JP)
HASHIMOTO YOSHIMI (JP)
TSUSHIMA KEIKO (JP)
SETOGUCHI YOICHI (JP)

A61K9/00; A61K9/50; A61K33/08; A61K9/20; (IPC1-7): A61K33/06; A61K33/08; A61K33/10; A61K33/12; A61K33/00

WO1992017161A1

1992-10-15

JPH06239756A	1994-08-30
JPH07101867A	1995-04-18
JPH0656677A	1994-03-01
JPH0344319A	1991-02-26
EP0338861A2	1989-10-25

See also references of EP 0761227A4

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