Title:
SOLID DISPERSION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/239065
Kind Code:
A1
Abstract:
Solid dispersion and a preparation method therefor. In a specific embodiment, the solid dispersion contains an active ingredient (R)-4-amino-1-(1-(but-2-ynyl)pyrrolidin-3-yl) )-3-(4-(2,6-difluorophenoxy)phenyl)-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one or a salt thereof, and a carrier material, and the pH value is adjusted; employing a method that adds an appropriate amount of acid effectively inhibits an emulsification phenomenon in a reverse solvent process, thereby obtaining solid dispersion having a moderate particle size and uniform content.
Inventors:
ZHOU XIANQIANG (CN)
DU ZHENXING (CN)
WANG JIE (CN)
DU ZHENXING (CN)
WANG JIE (CN)
Application Number:
PCT/CN2020/093206
Publication Date:
December 03, 2020
Filing Date:
May 29, 2020
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
A61K31/50; A61K9/26; A61K47/14; A61K47/38; A61P19/02
Domestic Patent References:
| WO2019007317A1 | 2019-01-10 | |||
| WO2016088074A1 | 2016-06-09 | |||
| WO2019007317A1 | 2019-01-10 | |||
| WO2016007185A1 | 2016-01-14 |
Foreign References:
| CN105640890A | 2016-06-08 | |||
| CN101677955A | 2010-03-24 | |||
| CN106924262A | 2017-07-07 | |||
| IN201621020494A | 2017-12-22 |
Other References:
"Chinese Pharmacopoeia", 2015
See also references of EP 3977997A4
See also references of EP 3977997A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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