Title:
SOLID STATE FORMS OF LUMATEPERONE SALTS AND PROCESSES FOR PREPARATION OF LUMATEPERONE AND SALTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/112941
Kind Code:
A3
Abstract:
The present disclosure relates to solid state forms of Lumateperone besylate and Lumateperone tosylate : R-(-)-mandelic acid, to various intermediates, to processes for their preparation and the preparation of Lumateperone or salt thereof, to pharmaceutical compositions and their use for the treatment of central nervous system disorders.
Inventors:
JANTON NIKOLINA (HR)
CERIĆ HELENA (HR)
MATEČIĆ MUŠANIĆ SANJA (HR)
MRSIC NATASA (HR)
LERMAN LIDIJA (HR)
MOMCILOVIC TINA DANCEVIC (HR)
SAGUD IVANA (HR)
JEGOROV ALEXANDR (CZ)
CERIĆ HELENA (HR)
MATEČIĆ MUŠANIĆ SANJA (HR)
MRSIC NATASA (HR)
LERMAN LIDIJA (HR)
MOMCILOVIC TINA DANCEVIC (HR)
SAGUD IVANA (HR)
JEGOROV ALEXANDR (CZ)
Application Number:
PCT/US2019/063519
Publication Date:
July 09, 2020
Filing Date:
November 27, 2019
Export Citation:
Assignee:
TEVA CZECH IND S R O (CZ)
TEVA PHARMA (US)
TEVA PHARMA (US)
International Classes:
C07D471/16; A61K31/4985; A61P25/00; C07C59/50; C07C69/76; C07C309/29; C07C309/30; C07D471/04
Domestic Patent References:
| WO2009114181A2 | 2009-09-17 | |||
| WO2018031535A1 | 2018-02-15 | |||
| WO2017172784A1 | 2017-10-05 | |||
| WO2017172811A1 | 2017-10-05 | |||
| WO2012071425A1 | 2012-05-31 | |||
| WO2016004911A1 | 2016-01-14 |
Other References:
BERGE, S.M. ET AL.: "Review Article: Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, 1977, pages 1 - 19, XP055515920
BYRN, S. ET AL.: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1995, pages 945 - 954, XP055531015, DOI: 10.1023/A:1016241927429
COLE, P.: "ITI-007", DRUGS OF THE FUTURE, vol. 40, no. 10, 2015, pages 643 - 650, XP055671175, ISSN: 0377-8282, DOI: 10.1358/dof.2015.040.10.2387229
GADADE, D.D. ET AL.: "Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development", ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 4, 2016, pages 479 - 494, XP055520634, ISSN: 2228-5881, DOI: 10.15171/apb.2016.062
BYRN, S. ET AL.: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1995, pages 945 - 954, XP055531015, DOI: 10.1023/A:1016241927429
COLE, P.: "ITI-007", DRUGS OF THE FUTURE, vol. 40, no. 10, 2015, pages 643 - 650, XP055671175, ISSN: 0377-8282, DOI: 10.1358/dof.2015.040.10.2387229
GADADE, D.D. ET AL.: "Pharmaceutical Cocrystals: Regulatory and Strategic Aspects, Design and Development", ADVANCED PHARMACEUTICAL BULLETIN, vol. 6, no. 4, 2016, pages 479 - 494, XP055520634, ISSN: 2228-5881, DOI: 10.15171/apb.2016.062
Attorney, Agent or Firm:
BREW, Michael R. et al. (US)
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