SOLUBLE BETA-GLUCAN-API COMPLEXES FOR PHARMACEUTICAL USE

WIPO Patent Application WO/2011/063776

A3

The invention relates to new water-soluble beta-glucan complexes with active pharmaceutical ingredients (APIs) and their pharmaceutical compositions. The formation of water soluble complexes according to the invention is achieved by addition of an API solution in an organic solvent (preferentially, 2-propanol, tetrahydrofuran, dioxane) to the solution of water-soluble glucan with control of the water/organic solvent ratio. For water-soluble APIs, such as doxorubicin, the complex is formed by addition of the solution of API to an aqueous glucan solution, followed by addition of a water-miscible organic solvent leading to conformation change of glucan and consequently to complex formation. The invention provides new water-soluble complexes of water-insoluble APIs and new slow release forms of water-soluble APIs. The preparation according to the invention could be applied for variety of formulation strategies, including oral drug products.

KRAL VLADIMIR (CZ)
KRALOVA JARMILA (CZ)
ZARUBA KAMIL (CZ)
FLIEGER MIROSLAV (CZ)
KEJIK ZDENEK (CZ)
MARTASEK PAVEL (CZ)

PCT/CZ2010/000122

May 31, 2012

November 25, 2010

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ZENTIVA KS (CZ)
KRAL VLADIMIR (CZ)
KRALOVA JARMILA (CZ)
ZARUBA KAMIL (CZ)
FLIEGER MIROSLAV (CZ)
KEJIK ZDENEK (CZ)
MARTASEK PAVEL (CZ)

A61K9/00; A61K31/337; A61K31/404; A61K31/41; A61K31/52; A61K31/551; A61K31/704; A61K47/36; A61K47/61

WO2006015627A1

2006-02-16

US20070213393A1	2007-09-13
EP0392487A2	1990-10-17
US5032401A	1991-07-16

JIROTKOVA, Ivana et al. (Ruzicka & GuttmannP.O. Box 44, Praha 2, CZ)

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