Title:
SOLUBLE FACTOR STIMULATION OF ATTACHMENT AND HEMIDESMOSOME ASSEMBLY IN EPITHELIAL CELLS
Document Type and Number:
WIPO Patent Application WO1995013103
Kind Code:
A3
Abstract:
A method for growing epithelial cells in vitro using soluble proteins secreted by 804G rat bladder carcinoma cells. These proteins are able to stimulate cell attachment and hemidesmosome formation in cells grown in contact with the proteins. The purification of these proteins from 804G culture supernatant is greatly facilitated by culturing the cells under low serum conditions.
Inventors:
QUARANTA VITO
HORMIA MARKETTA
HORMIA MARKETTA
Application Number:
PCT/US1994/012894
Publication Date:
July 06, 1995
Filing Date:
November 09, 1994
Export Citation:
Assignee:
DESMOS INC (US)
International Classes:
A61K35/12; A61L27/22; C12P21/02; A61L27/34; A61L27/38; A61L29/08; A61L31/00; A61L31/10; A61L33/00; C07K14/47; C07K14/78; C07K16/18; C12N5/00; C12N5/071; C12R1/91; (IPC1-7): A61L29/00; A61L31/00
Domestic Patent References:
| WO1989003392A1 | 1989-04-20 | |||
| WO1994023016A1 | 1994-10-13 |
Other References:
MIKAYO LANGHOFER ET AL.: "THE MATRIX SECRETED BY 804G CELLS CONTAINS LAMININ-RELATED COMPONENTS THAT PARTICIPATE IN HEMIDESMOSOME ASSEMBLY IN VITRO.", JOURNAL OF CELL SCIENCE, vol. 105, GB, pages 753 - 764
K.S. RIDDELLE ET AL.: "FORMATION OF HEMIDESMOSOMES IN VITRO BY A TRANSFORMED RAT BLADDER CELL LINE", THE JOURNAL OF CELL BIOLOGY, vol. 112, no. 1, US, pages 159 - 168
J.C.R. JONES ET AL.: "A FUNCTION FOR THE INTEGRIN A6B4 IN THE HEMIDESMOSOME.", CELL REGULATION, vol. 2, US, pages 427 - 438
K.S. RIDDELLE ETAL.: "HEMIDESMOSOMES IN THE EPITELIAL CELL LINE 804G: THEIR FATE DURING WOUND CLOSURE, MITOSIS AND DRUG INDUCED REORGANIZATION OF THE CYTOSKELETON", JOURNAL OF CELL SCIENCE, vol. 103, no. 2, GB, pages 475 - 490
K.S. RIDDELLE ET AL.: "FORMATION OF HEMIDESMOSOMES IN VITRO BY A TRANSFORMED RAT BLADDER CELL LINE", THE JOURNAL OF CELL BIOLOGY, vol. 112, no. 1, US, pages 159 - 168
J.C.R. JONES ET AL.: "A FUNCTION FOR THE INTEGRIN A6B4 IN THE HEMIDESMOSOME.", CELL REGULATION, vol. 2, US, pages 427 - 438
K.S. RIDDELLE ETAL.: "HEMIDESMOSOMES IN THE EPITELIAL CELL LINE 804G: THEIR FATE DURING WOUND CLOSURE, MITOSIS AND DRUG INDUCED REORGANIZATION OF THE CYTOSKELETON", JOURNAL OF CELL SCIENCE, vol. 103, no. 2, GB, pages 475 - 490
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