Title:
SOLUBLE MONOVALENT AND MULTIVALENT MHC CLASS II FUSION PROTEINS, AND USES THEREFOR
Document Type and Number:
WIPO Patent Application WO1998006749
Kind Code:
A3
Abstract:
The present invention is directed to the field of immunology. In particular, the present invention is directed to the design, production, and use of recombinant fusion proteins derived, in part, from the proteins of the human Major Histocompatibility Complex. 00000
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Inventors:
WUCHERPFENNIG KAI W (US)
STROMINGER JACK L (US)
STROMINGER JACK L (US)
Application Number:
PCT/US1997/014503
Publication Date:
June 11, 1998
Filing Date:
August 15, 1997
Export Citation:
Assignee:
HARVARD COLLEGE (US)
WUCHERPFENNIG KAI W (US)
STROMINGER JACK L (US)
WUCHERPFENNIG KAI W (US)
STROMINGER JACK L (US)
International Classes:
A61K38/00; C12N15/09; A61P37/04; C07K14/00; C07K14/74; C07K19/00; C12P21/02; (IPC1-7): C07K14/00
Domestic Patent References:
| WO1993010220A1 | 1993-05-27 | |||
| WO1996004314A1 | 1996-02-15 |
Other References:
COSSON, P. & BONIFACINO, J.S.: "Role of transmembrane domain interactions in the assembly of class II MHC molecules", SCIENCE, vol. 258, 1992, pages 659 - 662, XP002053286
KOZONO, H. ET AL.: "Production of soluble MHC class II proteins with covalently bound single peptides", NATURE, vol. 369, 1994, pages 151 - 154, XP002036522
CHANG, H.-C. ET AL.: "A general method for facilitating heterodimeric pairing ...", PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 11408 - 11412, XP002053287
KALANDADZE, A. ET AL.: "Expression of recombinant HLA-DR2 molecules", J. BIOL. CHEM., vol. 271, 16 August 1996 (1996-08-16), pages 20156 - 20162, XP002053288
KOZONO, H. ET AL.: "Production of soluble MHC class II proteins with covalently bound single peptides", NATURE, vol. 369, 1994, pages 151 - 154, XP002036522
CHANG, H.-C. ET AL.: "A general method for facilitating heterodimeric pairing ...", PROC. NATL. ACAD. SCI. USA, vol. 91, 1994, pages 11408 - 11412, XP002053287
KALANDADZE, A. ET AL.: "Expression of recombinant HLA-DR2 molecules", J. BIOL. CHEM., vol. 271, 16 August 1996 (1996-08-16), pages 20156 - 20162, XP002053288
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