Title:
SOLUTION PHASE PROCESSES FOR THE MANUFACTURE OF MACROCYCLIC DEPSIPEPTIDES AND NEW INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO/2014/057418
Kind Code:
A3
Abstract:
The invention relates to a method or process for solution phase chemical manufacture of depsipeptides of the formula (I), wherein the symbols have the meaning defined in the description, to new intermediates and their manufacture, as well as related invention embodiments.
Inventors:
ACEMOGLU MURAT (CH)
HELLSTERN HERIBERT (DE)
KOLLMER FELIX (CH)
SCHREIBER ROBERT (CH)
STETTLER HANS (CH)
HELLSTERN HERIBERT (DE)
KOLLMER FELIX (CH)
SCHREIBER ROBERT (CH)
STETTLER HANS (CH)
Application Number:
PCT/IB2013/059196
Publication Date:
July 10, 2014
Filing Date:
October 08, 2013
Export Citation:
Assignee:
NOVARTIS AG (CH)
ACEMOGLU MURAT (CH)
HELLSTERN HERIBERT (DE)
KOLLMER FELIX (CH)
SCHREIBER ROBERT (CH)
STETTLER HANS (CH)
ACEMOGLU MURAT (CH)
HELLSTERN HERIBERT (DE)
KOLLMER FELIX (CH)
SCHREIBER ROBERT (CH)
STETTLER HANS (CH)
International Classes:
C07K11/02
Domestic Patent References:
| WO2009024527A1 | 2009-02-26 | |||
| WO2012143888A1 | 2012-10-26 |
Other References:
YOKOKAWA F ET AL: "Synthetic studies of micropeptin T-20, a novel 3-amino-6-hydroxy-2-piperidone (Ahp)-containing cyclic depsipeptide", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 42, no. 34, 20 August 2001 (2001-08-20), pages 5903 - 5908, XP004295953, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(01)01136-4
YOKOKAWA F ET AL: "Total synthesis of somamide A, an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 43, no. 48, 25 November 2002 (2002-11-25), pages 8673 - 8677, XP004390459, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(02)02178-0
YOKOKAWA F ET AL: "Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 6, 7 February 2005 (2005-02-07), pages 1459 - 1480, XP027860763, ISSN: 0040-4020, [retrieved on 20050207]
YOKOKAWA F ET AL: "Total synthesis of somamide A, an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide", TETRAHEDRON LETTERS, PERGAMON, GB, vol. 43, no. 48, 25 November 2002 (2002-11-25), pages 8673 - 8677, XP004390459, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(02)02178-0
YOKOKAWA F ET AL: "Synthetic studies of the cyclic depsipeptides bearing the 3-amino-6-hydroxy-2-piperidone (Ahp) unit. Total synthesis of the proposed structure of micropeptin T-20", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 61, no. 6, 7 February 2005 (2005-02-07), pages 1459 - 1480, XP027860763, ISSN: 0040-4020, [retrieved on 20050207]
Attorney, Agent or Firm:
NOVARTIS AG (Basel, CH)
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