Title:
SOLUTION POLYMERIZATION OF HIGH MOLECULAR WEIGHT POLY(PHOSPHOESTERS) IN TOLUENE
Document Type and Number:
WIPO Patent Application WO1999000446
Kind Code:
A8
Abstract:
A process for making a high molecular weight poly(phosphoester) comprising the recurring monomeric units of formula (I), wherein X is -O- or -NR"-, where R" is H or alkyl; L is a divalent organic moiety, with the proviso that L cannot have formula (II); R' is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic, or heterocycloxy; and n is from about 25 to 2000, is described. The process comprises the steps of: (a) substantially dissolving p moles of a di-XH compound in a solvent comprising more than 75 % toluene at a first temperature between about -75 DEG C and +60 DEG C to form a reaction mixture; (b) while maintaining the reaction mixture at the first temperature, adding q moles, where p APPROX q, of a phosphorodihalo compound; (c) gradually increasing said first temperature at a rate of less than about 1.5 DEG C per minute as necessary to achieve a second temperature between about 0 DEG C and 150 DEG C, and mixing the reaction mixture at the second temperature to form the polymer of formula (I); and (d) isolating the polymer of formula (I).
Inventors:
ZHAO ZHONG
Application Number:
PCT/US1998/012976
Publication Date:
April 01, 1999
Filing Date:
June 23, 1998
Export Citation:
Assignee:
GUILFORD PHARM INC (US)
International Classes:
C08G79/04; (IPC1-7): C08G79/04
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