Title:
SOLUTION TYPE NASAL SPRAY FOR TREATING RHINITIS AND PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2023/138478
Kind Code:
A1
Abstract:
Disclosed are a solution type nasal spray containing 3-[(2-cyclopentyl-2-hydroxy-2-phenyl)ethoxy]-1-(3-phenoxypropyl)-1-azabicyclo[2,2,2]octonium salt or a derivative thereof, and a preparation method therefor. The components of the solution-type nasal spray include an active pharmaceutical ingredient, a solvent, a cosolvent, a bacteriostatic agent, a pH regulator and an osmotic pressure regulator. The nasal spray has high stability; a pharmacodynamic test result shows that the nasal spray takes effect quickly and is less irritating, and can be used for treating different types of rhinitis and cold accompanied rhinitis.
Inventors:
CHEN XIAOPING (CN)
WEN SHOUMING (CN)
GAO ZEJUN (CN)
WEN SHOUMING (CN)
GAO ZEJUN (CN)
Application Number:
PCT/CN2023/071983
Publication Date:
July 27, 2023
Filing Date:
January 13, 2023
Export Citation:
Assignee:
BEIJING SHOWBY PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K9/12; A61K31/49; A61P1/00; A61P1/04; A61P11/00; A61P11/02; A61P11/06; A61P11/14; A61P13/00; A61P13/02; A61P13/10; C07D453/02
Domestic Patent References:
| WO2015007073A1 | 2015-01-22 | |||
| WO2021218833A1 | 2021-11-04 |
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