Title:
SPARC (SECRETED PROTEIN, ACIDIC AND RICH IN CYSTEINE), A NEW TARGET FOR THE TREATMENT AND PREVENTION OF ACUTE LIVER FAILURE
Document Type and Number:
WIPO Patent Application WO/2015/033309
Kind Code:
A3
Abstract:
The invention relates to the identification of Secreted Protein, Acidic and Rich in Cysteine (SPARC) as a new therapeutic target in patients with fulminant hepatitis and allows the development of a strategy destined to protect the liver form damage. The invention relates to the treatment of acute liver failure or fulminant hepatitis by administering to a subject in need thereof an agent that inhibits at least partially the expression of SPARC and/or interferes with its biological function.
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Inventors:
MAZZOLINI GUILLERMO DANIEL (AR)
PEIXOTO ESTANISLAO (AR)
AQUINO JORGE (AR)
ATORRASAGASTI MARÍA C (AR)
PODHJACER OSVALDO (AR)
PEIXOTO ESTANISLAO (AR)
AQUINO JORGE (AR)
ATORRASAGASTI MARÍA C (AR)
PODHJACER OSVALDO (AR)
Application Number:
PCT/IB2014/064295
Publication Date:
November 12, 2015
Filing Date:
September 05, 2014
Export Citation:
Assignee:
INIS BIOTECH LLC (US)
CONSEJO NAC INVEST CIENT TEC (AR)
FUNDACION INST LELOIR FIL (AR)
CIVIL DE ESTUDIOS SUPERIORES ACES ASOC (AR)
CONSEJO NAC INVEST CIENT TEC (AR)
FUNDACION INST LELOIR FIL (AR)
CIVIL DE ESTUDIOS SUPERIORES ACES ASOC (AR)
International Classes:
C07K14/47; C07K16/18; C12N15/113
Other References:
CAMINO ET AL: "Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats", JOURNAL OF GENE MEDICINE, JOHN WILEY & SONS, INC, US, vol. 10, no. 9, 1 September 2008 (2008-09-01), pages 993 - 1004, XP008161886, ISSN: 1099-498X, [retrieved on 20080709], DOI: 10.1002/JGM.1228
CATALINA ATORRASAGASTI ET AL: "Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice", PLOS ONE, vol. 8, no. 2, 11 February 2013 (2013-02-11), pages e54962, XP055165275, DOI: 10.1371/journal.pone.0054962
LEDDA M F ET AL: "Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 3, no. 2, 1 February 1997 (1997-02-01), pages 171 - 176, XP002534137, ISSN: 1078-8956, DOI: 10.1038/NM0297-171
TAKAYUKI IWAKI ET AL: "Recombinant Adenovirus Vector Bearing Antisense Macrophage Migration Inhibitory Factor cDNA Prevents Acute Lipopolysaccharide-Induced Liver Failure in Mice", LABORATORY INVESTIGATION, vol. 83, no. 4, 1 April 2003 (2003-04-01), pages 561 - 570, XP055165362, ISSN: 0023-6837, DOI: 10.1097/01.LAB.0000062857.26210.EF
E PEIXOTO ET AL: "SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage", GENE THERAPY, vol. 22, no. 1, 1 January 2015 (2015-01-01), pages 9 - 19, XP055165280, ISSN: 0969-7128, DOI: 10.1038/gt.2014.102
CATALINA ATORRASAGASTI ET AL: "Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice", PLOS ONE, vol. 8, no. 2, 11 February 2013 (2013-02-11), pages e54962, XP055165275, DOI: 10.1371/journal.pone.0054962
LEDDA M F ET AL: "Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 3, no. 2, 1 February 1997 (1997-02-01), pages 171 - 176, XP002534137, ISSN: 1078-8956, DOI: 10.1038/NM0297-171
TAKAYUKI IWAKI ET AL: "Recombinant Adenovirus Vector Bearing Antisense Macrophage Migration Inhibitory Factor cDNA Prevents Acute Lipopolysaccharide-Induced Liver Failure in Mice", LABORATORY INVESTIGATION, vol. 83, no. 4, 1 April 2003 (2003-04-01), pages 561 - 570, XP055165362, ISSN: 0023-6837, DOI: 10.1097/01.LAB.0000062857.26210.EF
E PEIXOTO ET AL: "SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage", GENE THERAPY, vol. 22, no. 1, 1 January 2015 (2015-01-01), pages 9 - 19, XP055165280, ISSN: 0969-7128, DOI: 10.1038/gt.2014.102
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