Title:
SPATIAL FOR ALTERING CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO2005060364
Kind Code:
A3
Abstract:
This disclosure provides methods useful for altering cell proliferation by modifying SPATIAL activity in cells. In some methods, thymocyte numbers in subjects with disease-associated immunodeficiencies are increased by administering an agent that inhibits SPATIAL activity. Also provided are methods useful for increasing thymocyte number in a subject by administering an agent that interferes with an interaction between SPATIAL and Uba3. In other methods, cell growth is inhibited by introducing or expressing a SPATIAL or SPATIAL-related polypeptide or nucleic acid in one or more cell(s), such as neoplastic cell(s). Further provided are methods of identifying agents that modify (for example, inhibit) SPATIAL expression or activity, or which interfere with an interaction between SPATIAL and Uba3 polypeptides, and therefore which are useful in influencing thymocyte number.
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Inventors:
FLOMERFELT FRANCIS A (US)
GRESS RONALD E (US)
GRESS RONALD E (US)
Application Number:
PCT/US2003/036874
Publication Date:
January 12, 2006
Filing Date:
November 18, 2003
Export Citation:
Assignee:
US GOV HEALTH & HUMAN SERV (US)
FLOMERFELT FRANCIS A (US)
GRESS RONALD E (US)
FLOMERFELT FRANCIS A (US)
GRESS RONALD E (US)
International Classes:
C07K14/47; (IPC1-7): C12N9/22; C07H21/04
Other References:
FLOMERTFELT F. ET AL.: "Spatial, a gene expressed in thymic stromal cells, depends on threedimensional thymus organization for its expression.", GENES IMMUN., vol. 1, 2000, pages 391 - 401, XP008056922
PHAM T. ET AL.: "Assessment of Thymic Activity in Human Immunodeficiency Virus-Negative and -Positive Adolescents by Real-Time PCR Quantitation of T-Cell Receptor Rearrabgement Excison Circles.", CLIN. DIAG. LAB. IMMUN., vol. 10, no. 2, March 2003 (2003-03-01), pages 323 - 328, XP002992376
MCCUNE J. ET AL.: "Thymic function in HIV-1 disease.", SEMINARS IN IMMUN., vol. 9, 1997, pages 397 - 404, XP002992377
NAPOLITANO L. ET AL.: "Effects of IL-7 on Early Human Thymocyte Progenitor Cells In Vitro and in SCID-hu Thy/Liv Mice.", J. IMMUN., vol. 171, 2003, pages 645 - 654, XP002992378
PHAM T. ET AL.: "Assessment of Thymic Activity in Human Immunodeficiency Virus-Negative and -Positive Adolescents by Real-Time PCR Quantitation of T-Cell Receptor Rearrabgement Excison Circles.", CLIN. DIAG. LAB. IMMUN., vol. 10, no. 2, March 2003 (2003-03-01), pages 323 - 328, XP002992376
MCCUNE J. ET AL.: "Thymic function in HIV-1 disease.", SEMINARS IN IMMUN., vol. 9, 1997, pages 397 - 404, XP002992377
NAPOLITANO L. ET AL.: "Effects of IL-7 on Early Human Thymocyte Progenitor Cells In Vitro and in SCID-hu Thy/Liv Mice.", J. IMMUN., vol. 171, 2003, pages 645 - 654, XP002992378
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