Title:
SPATIAL TRANSCRIPTOME INFORMATION ANALYSIS APPARATUS AND ANALYSIS METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/195564
Kind Code:
A1
Abstract:
The present invention relates to a spatial transcriptome information analysis apparatus and a spatial transcriptome information analysis method using same and to a spatial transcriptome information analysis apparatus using reconstitution data in which spatial transcriptome data is reconstituted to make interpolation in empty spaces lacking transcriptome information on a tissue image (TI) and a spatial transcriptome information analysis method using same. The present invention discloses a spatial transcriptome information analysis apparatus (100) comprising: an information receptor (110) for receiving spatial transcriptome data consisting of location information for a plurality of spots (P1, …, PN) spaced from each other on a tissue image (TI) and transcriptome information (R1, …, RN) respectively corresponding to the plurality of spots (P1, …, PN; a data reconstituting unit (120) for generating reconstituted data in which the spatial transcriptome data is reconstituted to make interpolation in the empty space lacking the transcriptome information (R1, …, RN) between the plurality of spots (P1, …, PN); and a spatial transcriptome information analyzer (130) for analyzing a gene expression pattern on the basis of the reconstituted data.
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Inventors:
SEO MI-KYOUNG (KR)
LEE DAESEUNG (KR)
CHOI HONGYOON (KR)
LEE DAESEUNG (KR)
CHOI HONGYOON (KR)
Application Number:
PCT/KR2022/005223
Publication Date:
October 12, 2023
Filing Date:
April 11, 2022
Export Citation:
Assignee:
PORTRAI INC (KR)
International Classes:
G16B25/00; G06N3/08; G16B40/30; G16B45/00
Foreign References:
| US20210199584A1 | 2021-07-01 | |||
| KR20220033484A | 2022-03-16 | |||
| KR102170297B1 | 2020-10-26 |
Other References:
DONG KANGNING, ZHANG SHIHUA: "Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder", NATURE COMMUNICATIONS, vol. 13, no. 1, 1 April 2022 (2022-04-01), pages 1739, XP093096032, DOI: 10.1038/s41467-022-29439-6
BERGENSTRÅHLE LUDVIG; HE BRYAN; BERGENSTRÅHLE JOSEPH; ABALO XESÚS; MIRZAZADEH REZA; THRANE KIM; JI ANDREW L.; ANDERSSON ALMA; LARS: "Super-resolved spatial transcriptomics by deep data fusion", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 40, no. 4, 29 November 2021 (2021-11-29), New York, pages 476 - 479, XP037799136, ISSN: 1087-0156, DOI: 10.1038/s41587-021-01075-3
BERGENSTRÅHLE LUDVIG; HE BRYAN; BERGENSTRÅHLE JOSEPH; ABALO XESÚS; MIRZAZADEH REZA; THRANE KIM; JI ANDREW L.; ANDERSSON ALMA; LARS: "Super-resolved spatial transcriptomics by deep data fusion", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP US, NEW YORK, vol. 40, no. 4, 29 November 2021 (2021-11-29), New York, pages 476 - 479, XP037799136, ISSN: 1087-0156, DOI: 10.1038/s41587-021-01075-3
Attorney, Agent or Firm:
AIP PATENT & LAW FIRM (KR)
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