Title:
SPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING NKG2DL AND CAR-T CELL THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/165913
Kind Code:
A1
Abstract:
Provided are a specific chimeric antigen receptor targeting NKG2DL and a CAR-T cell thereof, as well as a preparation method and the use thereof. The CAR-T cell can effectively target and attack a plurality of tumour cells, and can be used to prepare a preparation for treating tumours, in particular, a preparation for treating positive tumour cells expressing NKG2DL.
Inventors:
DAI HONGJIU (CN)
ZHANG ZHENG (CN)
LI XIAOLIANG (CN)
ZHOU JIE (CN)
ZHAO XUDONG (CN)
XIONG BO (CN)
ZHANG ZHENG (CN)
LI XIAOLIANG (CN)
ZHOU JIE (CN)
ZHAO XUDONG (CN)
XIONG BO (CN)
Application Number:
PCT/CN2017/076795
Publication Date:
September 20, 2018
Filing Date:
March 15, 2017
Export Citation:
Assignee:
NANJING KAEDI BIOTECH INC (CN)
International Classes:
C07K19/00; A61K35/17; A61P35/00; C12N5/10; C12N15/62; C12N15/63; C12N15/861; C12N15/867
Foreign References:
| CN106480097A | 2017-03-08 |
Other References:
DE-GANG SONG ET AL.: "Chimeric NKG2D CAR-Expressing T Cell -Mediated Attack of Human Ovarian Cancer Is Enhanced by Histone Deacetylase Inhibition", HUMAN GENE THERAPY, vol. 24, no. 3, 31 March 2013 (2013-03-31), pages 295 - 305, XP055370704, ISSN: 1043-0342
CHARLES L. SENTMAN ET AL.: "NKG2D CARs as Cell Therapy for Cancer", THE CANCER JOURNAL, vol. 20, no. 2, 30 April 2014 (2014-04-30), pages 156 - 159, XP055310339, ISSN: 1528-9117
HEATHER VANSEGGELEN ET AL.: "T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice", MOLECULAR THERAPY, vol. 23, no. 10, 31 October 2015 (2015-10-31), pages 1600 - 1610, XP055310335, ISSN: 1525-0016
MANFRED LEHNER ET AL.: "Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection", PLOS ONE, vol. 7, no. 2, 15 February 2012 (2012-02-15), XP055262099, ISSN: 1932-6203
CHARLES L. SENTMAN ET AL.: "NKG2D CARs as Cell Therapy for Cancer", THE CANCER JOURNAL, vol. 20, no. 2, 30 April 2014 (2014-04-30), pages 156 - 159, XP055310339, ISSN: 1528-9117
HEATHER VANSEGGELEN ET AL.: "T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice", MOLECULAR THERAPY, vol. 23, no. 10, 31 October 2015 (2015-10-31), pages 1600 - 1610, XP055310335, ISSN: 1525-0016
MANFRED LEHNER ET AL.: "Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection", PLOS ONE, vol. 7, no. 2, 15 February 2012 (2012-02-15), XP055262099, ISSN: 1932-6203
Attorney, Agent or Firm:
SUZHOU ZHONGHE INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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