Title:
SPECIFIC HOST FACTOR OF HEPATITIS B VIRUS INFECTION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/143932
Kind Code:
A1
Abstract:
The present invention provides a specific host factor of hepatitis B virus infection. The specific host factor CREBH can remarkably enhance hepatitis B virus infection, can promote the invasion of a hepatitis B virus, and also has certain enhancement for the transcription of the hepatitis B virus. During the hepatitis B virus infection, the EGF-like structure field of the amino end of a specific host factor SCARF2 in a CREBH regulation and control pathway plays a crucial role in the infection and invasion of the hepatitis B virus. By means of two kinds of specific host factors having correlation, a new target is found for inhibiting the hepatitis B virus infection.
Inventors:
LI CONG (CN)
WANG YIXUE (CN)
LI WENHUI (CN)
WANG YIXUE (CN)
LI WENHUI (CN)
Application Number:
PCT/CN2021/072742
Publication Date:
July 22, 2021
Filing Date:
January 19, 2021
Export Citation:
Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
C07K14/705; A61K38/16; A61P31/20; C12N15/09
Other References:
DATABASE Protein 19 June 2021 (2021-06-19), ANONYMOUS: "scavenger receptor class F member 2 isoform 1 precursor [Homo sapiens]", XP055830036, retrieved from NCBI Database accession no. NP_699165
VALESKA TERPSTRA, EDWIN S. VAN AMERSFOORT, AGNES G. VAN VELZEN, JOHAN KUIPER, THEO J.C. VAN BERKEL: "Hepatic and Extrahepatic Scavenger Receptors Function in Relation to Disease", ARTERIOSCLER THROMB VASC BIOL, vol. 20, no. 8, 1 August 2000 (2000-08-01), pages 1860 - 1872, XP055830038
YING CHEN, ZUXIONG HUANG, DI MA, LIQIAN CHEN, QINTAO LAI, XUAN HUANG, JIA ZHOU, XIAOYONG ZHANG, QIANG MA, ZHENGLIANG CHEN & DAMING: "Involvement of soluble scavenger receptor A in suppression of T cell activation in patients with chronic hepatitis B", BMC IMMUNOLOGY, vol. 16, no. 1, 29, 16 May 2015 (2015-05-16), pages 1 - 11, XP021222489, ISSN: 1471-2172, DOI: 10.1186/s12865-015-0088-x
VALESKA TERPSTRA, EDWIN S. VAN AMERSFOORT, AGNES G. VAN VELZEN, JOHAN KUIPER, THEO J.C. VAN BERKEL: "Hepatic and Extrahepatic Scavenger Receptors Function in Relation to Disease", ARTERIOSCLER THROMB VASC BIOL, vol. 20, no. 8, 1 August 2000 (2000-08-01), pages 1860 - 1872, XP055830038
YING CHEN, ZUXIONG HUANG, DI MA, LIQIAN CHEN, QINTAO LAI, XUAN HUANG, JIA ZHOU, XIAOYONG ZHANG, QIANG MA, ZHENGLIANG CHEN & DAMING: "Involvement of soluble scavenger receptor A in suppression of T cell activation in patients with chronic hepatitis B", BMC IMMUNOLOGY, vol. 16, no. 1, 29, 16 May 2015 (2015-05-16), pages 1 - 11, XP021222489, ISSN: 1471-2172, DOI: 10.1186/s12865-015-0088-x
Attorney, Agent or Firm:
IPSUNNY (CN)
Download PDF:
Previous Patent: SPECIFIC HOST FACTOR FOR HEPATITIS B VIRUS INFECTION AND USE THEREOF
Next Patent: DENITRATION METHOD IN ALKALI RECOVERY FURNACE
Next Patent: DENITRATION METHOD IN ALKALI RECOVERY FURNACE