Title:
SPECIFIC HUMAN ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2005005455
Kind Code:
A3
Abstract:
The present invention provides antibodies that bind an epitope of PSGL-1 comprising the motif D-X-Y-D, wherein X represents any amino acid or the covalent linkage between D and Y, and Y is sulfated, which antibody can be complexed with one or more copies of an agent. The antibodies of the invention can be used in a method of inducing antibody-dependent cell cytotoxicity and/or stimulating natural killer (NK) cells or T cells. In addition, by administering these antibodies to a patient in need thereof, a method of inducing cell death is provided. A method of preventing infection by a virus (e.g., HIV) by administering to a patient in need thereof an antibody of the present invention is also provided. The present invention also provides a method of introducing an agent into a cell that expresses sulfated PSGL-1 by coupling or complexing an agent to an antibody of the present invention and administering the complex to the cell. Finally, the present invention provides methods of diagnosis, prognosis and staging using the present antibodies.
Inventors:
LEVANON AVIGDOR (IL)
VOGEL TIKVA (IL)
PLAKSIN DANIEL (IL)
PERETZ TUVIA (IL)
AMIT BOAZ (IL)
COOPERMAN LENA (IL)
HAGAY YOCHEVED (IL)
SZANTON ESTHER (IL)
KANFI YARIV (IL)
BEN-LEVY RACHEL (IL)
SZRAJBER TALI (IL)
VOGEL TIKVA (IL)
PLAKSIN DANIEL (IL)
PERETZ TUVIA (IL)
AMIT BOAZ (IL)
COOPERMAN LENA (IL)
HAGAY YOCHEVED (IL)
SZANTON ESTHER (IL)
KANFI YARIV (IL)
BEN-LEVY RACHEL (IL)
SZRAJBER TALI (IL)
Application Number:
PCT/US2004/021099
Publication Date:
February 16, 2006
Filing Date:
June 30, 2004
Export Citation:
Assignee:
BIO TECHNOLOGY GENERAL ISRAEL (IL)
LEVANON AVIGDOR (IL)
VOGEL TIKVA (IL)
PLAKSIN DANIEL (IL)
PERETZ TUVIA (IL)
AMIT BOAZ (IL)
COOPERMAN LENA (IL)
HAGAY YOCHEVED (IL)
SZANTON ESTHER (IL)
KANFI YARIV (IL)
BEN-LEVY RACHEL (IL)
SZRAJBER TALI (IL)
LEVANON AVIGDOR (IL)
VOGEL TIKVA (IL)
PLAKSIN DANIEL (IL)
PERETZ TUVIA (IL)
AMIT BOAZ (IL)
COOPERMAN LENA (IL)
HAGAY YOCHEVED (IL)
SZANTON ESTHER (IL)
KANFI YARIV (IL)
BEN-LEVY RACHEL (IL)
SZRAJBER TALI (IL)
International Classes:
A61K47/48; C07K16/06; C07K16/28; C07K16/36; C07K16/44; C12N5/07; C12N5/0783; C12N5/09; (IPC1-7): A61K39/395
Foreign References:
| US6406867B1 | 2002-06-18 |
Other References:
LI F. ET AL: "Visualization of P-selectin glycoprotein ligand-1 as a highly extended molecule and mapping of protein epitopes for monoclonal antibodies", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 11, 1996, pages 6342 - 6348, XP002179642
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