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Title:
SPECIFIC KINASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2006036941
Kind Code:
A3
Abstract:
Resorcylic acid lactones having a C5-C6 cis double bond and a ketone at C7 and other compounds capable of Michael adduct formation are potent and stable inhibitors of a subset of protein kinases having a specific cysteine residue in the ATP binding site.

Inventors:
SANTI DANIEL V (US)
REID RALPH C (US)
HUTCHINSON RICHARD C (US)
SUNDERMANN KURT F (US)
LAU JANICE (US)
Application Number:
US2005034537W
Publication Date:
October 26, 2006
Filing Date:
September 26, 2005
Export Citation:
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Assignee:
KOSAN BIOSCIENCES INCORPORATED
SANTI, DANIEL, V.
REID, RALPH, C.
HUTCHINSON, RICHARD, C.
SUNDERMANN, KURT, F.
LAU, JANICE
International Classes:
C07D267/22; C07D225/04; C07D245/00; C07D281/18; C07D291/00; C07D313/00; C07D321/00; C07D321/10; C07D321/12; C07D323/00; C07D327/00; C07D337/12; C07D337/16; C07D339/00; C07D341/00; C07D343/00; C07D405/00; C07D407/00; C07D409/00; C07D411/00; C07D487/00; C07D493/00; C07D495/00; C07D497/00; C07D513/00
Domestic Patent References:
WO2002048135A12002-06-20
Foreign References:
US20040224936A12004-11-11
US5795910A1998-08-18
Other References:
VONGVILAI P. ET AL.: 'Ketene acetal and spiroacetal constituents of the marine fungus aigialus parvus BCC 5311' J. NAT. PROD. vol. 67, 2004, pages 457 - 460, XP008117853
ELLESTAD ET AL.: 'New zearalenone related macrolides and isocoumarins from an unidentified fungus' J. ORG. CHEM. vol. 43, no. 12, 1978, pages 2339 - 2343, XP008117855
TAKEHANA K. ET AL.: 'A radiciol-related macrocyclic nonaketide compound' BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS vol. 257, 1999, pages 19 - 23, XP008117854
WILLIAMS ET AL.: 'Ro 09-2210 exhibits potent anti-proliferative effects on activated T cells by selectively blocking MKK activity' BIOCHEMISTRY vol. 37, 1998, pages 9579 - 9585, XP008117831
See also references of EP 1794137A2
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