Title:
SPECIFIC MARKERS FOR PANCREATIC CANCER
Document Type and Number:
WIPO Patent Application WO2004055519
Kind Code:
A3
Abstract:
The present invention provides polypeptides which are up- or down-regulated in pancreatic cancer and which can be used as markers for diagnosis of pancreatic cancer. The invention also provides an in vitro method for the diagnosis of pancreatic cancer and/or the susceptibility to pancreatic cancer comprising the steps of a) obtaining a biological sample; and b) detecting and/or measuring the increase of one or more polypeptides as disclosed herein. Furthermore, screening methods relating to inhibitors and antagonists of the specific polypeptides disclosed herein are provided.
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Inventors:
CHEN JIE
HU LIPING
LIU TONG HUA
LU ZHAO HUI
SHEN YAN
HU LIPING
LIU TONG HUA
LU ZHAO HUI
SHEN YAN
Application Number:
PCT/EP2003/014057
Publication Date:
November 04, 2004
Filing Date:
December 11, 2003
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
SINOGENOMAX CO LTD CHINESE NAT (CN)
SINOGENOMAX CO LTD CHINESE NAT (CN)
International Classes:
G01N33/574; G01N33/68; (IPC1-7): G01N33/68; G01N33/574
Domestic Patent References:
| WO2001013118A2 | 2001-02-22 |
Foreign References:
| EP0582477A1 | 1994-02-09 | |||
| US20020150894A1 | 2002-10-17 |
Other References:
NAKATA BUNZO ET AL: "Immunohistochemical study on cathepsin B and D in pancreatic cancer", ONCOLOGY REPORTS, vol. 1, no. 3, 1994, pages 543 - 546, XP009029634
YAMAGUCHI N ET AL: "CHARACTERIZATION OF NEW HUMAN PANCREATIC CANCER CELL LINES WHICH PROPAGATE IN A PROTEIN-FREE CHEMICALLY DEFINED MEDIUM", CANCER RESEARCH, vol. 50, no. 21, 1990, pages 7008 - 7014, XP001180932, ISSN: 0008-5472
LACOBUZIO-DONAHUE C A ET AL: "DISCOVERY OF NOVEL TUMOR MARKERS OF PANCREATIC CANCER USING GLOBAL GENE EXPRESSION TECHNOLOGY", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, vol. 160, no. 4, April 2002 (2002-04-01), pages 1239 - 1249, XP008003747, ISSN: 0002-9440
GANSAUGE F ET AL: "[Prognostic value of molecular biologogy and immunologic parameters in human pancreatic carcinoma]", LANGENBECKS ARCHIV FUR CHIRURGIE. SUPPLEMENT. KONGRESSBAND. DEUTSCHE GESELLSCHAFT FUR CHIRURGIE. KONGRESS. GERMANY 1998, vol. 115, no. Suppl I, 1998, pages 69 - 72, XP001180854, ISSN: 0942-2854
SCHWARTZ MORTON K: "Tissue cathepsins as tumor markers", CLINICA CHIMICA ACTA, vol. 237, no. 1-2, 1995, pages 67 - 78, XP002277571, ISSN: 0009-8981
BEN-ZE'EV AVRI: "The use of two-dimensional gel electrophoresis in studies on the role of cytoskeletal plaque proteins as tumor suppressors", ELECTROPHORESIS, vol. 17, no. 11, 1996, pages 1752 - 1763, XP009029657, ISSN: 0173-0835
YAMAGUCHI N ET AL: "CHARACTERIZATION OF NEW HUMAN PANCREATIC CANCER CELL LINES WHICH PROPAGATE IN A PROTEIN-FREE CHEMICALLY DEFINED MEDIUM", CANCER RESEARCH, vol. 50, no. 21, 1990, pages 7008 - 7014, XP001180932, ISSN: 0008-5472
LACOBUZIO-DONAHUE C A ET AL: "DISCOVERY OF NOVEL TUMOR MARKERS OF PANCREATIC CANCER USING GLOBAL GENE EXPRESSION TECHNOLOGY", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, vol. 160, no. 4, April 2002 (2002-04-01), pages 1239 - 1249, XP008003747, ISSN: 0002-9440
GANSAUGE F ET AL: "[Prognostic value of molecular biologogy and immunologic parameters in human pancreatic carcinoma]", LANGENBECKS ARCHIV FUR CHIRURGIE. SUPPLEMENT. KONGRESSBAND. DEUTSCHE GESELLSCHAFT FUR CHIRURGIE. KONGRESS. GERMANY 1998, vol. 115, no. Suppl I, 1998, pages 69 - 72, XP001180854, ISSN: 0942-2854
SCHWARTZ MORTON K: "Tissue cathepsins as tumor markers", CLINICA CHIMICA ACTA, vol. 237, no. 1-2, 1995, pages 67 - 78, XP002277571, ISSN: 0009-8981
BEN-ZE'EV AVRI: "The use of two-dimensional gel electrophoresis in studies on the role of cytoskeletal plaque proteins as tumor suppressors", ELECTROPHORESIS, vol. 17, no. 11, 1996, pages 1752 - 1763, XP009029657, ISSN: 0173-0835
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