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Title:
SPHERE FORMING COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO/2017/218783
Kind Code:
A1
Abstract:
Disclosed is a composition that begins as a multi-phase structure including a plurality of immiscible liquids that, upon agitation, encapsulates and suspends one of the plurality of liquids (e.g., in spheres). In some embodiments, the composition includes a water phase and an anhydrous phase. The composition can include a thickener added to the water phase to allow the water molecules to encapsulate the anhydrous phase into spheres. The formed spheres are stable and can be configured to last for specific durations depending on modifications to the formula. In some embodiments, the spheres can release back into the multi-phase structure after a specific period of time. The formulations disclosed herein can act as a vehicle or a base formulation to which additional ingredients can be added. The disclosed formulation, in addition to enabling the intermixing of two immiscible liquids, can provide a number of additional benefits.

Inventors:
GOLDSBERRY SUSAN (US)
GARCINES LYNDON S (US)
LY YEN H (US)
Application Number:
PCT/US2017/037690
Publication Date:
December 21, 2017
Filing Date:
June 15, 2017
Export Citation:
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Assignee:
BENCHMARK COSMETIC LABORATORIES INC (US)
International Classes:
A61K8/02; A61K8/34; A61K8/365; A61K8/67; A61K8/73; A61K8/89; A61Q5/00; A61Q19/00
Domestic Patent References:
WO1999011237A11999-03-11
Foreign References:
US20150050321A12015-02-19
US5362418A1994-11-08
US20050100569A12005-05-12
US6277388B12001-08-21
Attorney, Agent or Firm:
MALLON, Joseph J. (US)
Download PDF:
Claims:
WHAT IS CLAIMED IS:

1. A composition configured to form spheres when agitated, the composition comprising:

(a) a water phase comprising between about 25% to about 90% of the composition, the water phase comprising:

(i) water, comprising between about 60% to about 95%,

(ii) a first gelling agent configured to alter the size and duration of the formed spheres, the first gelling agent comprising sclerotium gum and comprising between about 0.10% to about 1.50% of the water phase,

(iii) a second gelling agent configured to suspend an anhydrous phase within the water phase, the second gelling agent comprising xanthan gum and comprising between about 0.10% to about 2.00% of the water phase,

(iv) a skin conditioning agent configured to enhance the penetration of the composition into the skin, the skin conditioning agent comprising at least one of pentylene glycol, butylene glycol, and another water soluble skin conditioning agent and comprising between about 1.00% to about 5.00% of the water phase, and

(v) a preservative comprising between about 0.20% to about 5.00%; and

(b) the anhydrous phase comprising between about 10% to about 75% of the composition, the anhydrous phase comprising:

a conditioning agent configured to set the size and duration of the formed spheres, the conditioning agent comprising at least one of isododecane, isohexadecane, Botanisil GB-21, and Botanisil GB-41, and comprising between about 5.00% to about 70.00% of the anhydrous phase.

2. The composition of Claim 1, wherein the water phase has a pH between about 3.5 to about 8.0.

3. The composition of Claim 1, wherein the water phase has a viscosity between about 500 to about 15,000 cps.

4. The composition of Claim 1, wherein the anhydrous phase has a viscosity between about 50 to about 10,000 cps

5. The composition of Claim 1, the composition further including a complexion brightener.

6. The composition of Claim 5, wherein the complexion brightener comprises at least one of neurocap, brightenyl, nicainamide, specwhite plus, or copper peptide.

7. The composition of Claim 1, the composition further including an alpha hydroxyl acid configured to help break down the spheres formed by the composition.

8. The composition of Claim 7, wherein the alpha hydroxyl acid comprises at least one of glycolic acid or lactic acid.

9. The composition of Claim 7, wherein the alpha hydroxyl acid comprises between about 1.00% to about 20.00% of the water phase.

10. The composition of Claim 9, the composition further including an inorganic salt configured to neutralize the glycolic acid in the composition.

11. The composition of Claim 10, wherein the inorganic salt comprises at least one of sodium hydroxide or aminom ethyl propanol.

12. The composition of Claim 11, wherein the inorganic salt comprises between about 0.20% to about 4.00% of the water phase.

13. The composition of Claim 1, wherein the preservative comprises propanediol.

14. The composition of Claim 1, wherein the conditioning agent is combined with at least one of dimethicone or a dimethicone crossypolymer.

15. The composition of Claim 1, wherein the anhydrous phase further comprises at least one of dimethicone, a dimethicone crosspolymer, cyclopentasiloxane, a cyclopentasiloxane blend, cyclohexasiloxane, cyclotetrasiloxane, cycloheptasiloxane, and phenyl trimethicone.

16. The composition of Claim 15, wherein the at least one of cyclopentasiloxane, cyclohexasiloxane, cyclotetrasiloxane, and cycloheptasiloxane comprises between about 10.00% to about 100.00% of the anhydrous phase.

17. The composition of any one of Claims 1-16 wherein the spheres formed have a diameter between approximately 0.5 to approximately 5 mm.

18. The composition of any one of Claims 1-17 wherein the spheres stay formed for any one of at least 30 minutes, at least 1 hour, at least 2 hours, at least 8 hours, at least 6 months, at least 1 year, and at least 2 years.

19. A topical composition configured to form spheres when agitated, the composition comprising:

(a) a water phase comprising:

(i) water,

(ii) a first gelling agent configured to alter the size and duration of the formed spheres,

(iii) a second gelling agent configured to suspend the anhydrous phase within the water phase,

(iv) a skin conditioning agent configured to enhance the penetration of the composition into the skin, and

(v) a preservative; and

(b) an anhydrous phase comprising:

(i) a conditioning agent configured to set the size and duration of the formed spheres.

20. The topical composition of Claim 19, wherein water can compose between about 60% to about 95% of the water phase.

21. The topical composition of any one of Claims 19-20, wherein the anhydrous phase makes up between about 10% to about 75% of the topical composition.

22. The topical composition of any one of Claims 19-21, wherein the water phase makes up between about 25% to about 90% of the topical composition.

23. The topical composition of any one of Claims 19-22, wherein the water phase has a pH between about 3.5 to about 8.0.

24. The topical composition of any one of Claims 19-23, wherein the water phase has a viscosity between about 500 to about 15,000 cps.

25. The topical composition of any one of Claims 19-24, wherein the anhydrous phase has a viscosity between about 50 to about 10,000 cps

26. The topical composition of any one of Claims 19-25, wherein the first gelling agent comprises sclerotium gum.

27. The topical composition of any one of Claims 19-26, wherein the sclerotium gum comprises between about 0.10% to about 1.50% of the water phase.

28. The topical composition of any one of Claims 19-27, wherein the second gelling agent comprises xanthan gum.

29. The topical composition of any one of Claims 19-28, wherein the xanthan gum comprises between about 0.10%> to about 2.00% of the water phase.

30. The topical composition of any one of Claims 19-29, wherein the skin conditioning agent is water soluble.

31. The topical composition of any one of Claims 19-30, wherein the skin conditioning agent comprises at least one of pentylene glycol, butylene glycol, and another water soluble skin conditioning agent.

32. The topical composition of any one of Claims 19-31, wherein the skin conditioning agent comprises between about 1.00%> to about 5.00%> of the water phase.

33. The topical composition of any one of Claims 19-32, the composition further including a complexion brightener.

34. The topical composition of Claim 33, wherein the complexion brightener comprises at least one of neurocap, brightenyl, nicainamide, specwhite plus, or copper peptide.

35. The topical composition of any one of Claims 19-34, the composition further including an alpha hydroxyl acid configured to help break down the spheres formed by the topical composition.

36. The topical composition of Claim 35, wherein the alpha hydroxyl acid comprises at least one of glycolic acid or lactic acid.

37. The topical composition of any one of Claims 35-36, wherein the alpha hydroxyl acid comprises between about 1.00%> to about 20.00%> of the water phase.

38. The topical composition of any one of Claims 35-37, the composition further including an inorganic salt configured to neutralize the glycolic acid in the topical composition.

39. The topical composition of Claim 38, wherein the inorganic salt comprises at least one of sodium hydroxide or aminom ethyl propanol.

40. The topical composition of Claim 39, wherein the inorganic salt comprises between about 0.20% to about 4.00% of the water phase.

41. The topical composition of any one of Claims 19-40, wherein the preservative is water soluble and comprises between about 0.20% to about 1.00% of the water phase.

42. The topical composition of any one of Claims 19-41, wherein the preservative comprises propanediol.

43. The topical composition of Claim 42, wherein the propanediol comprises between about 1.00% to about 5.00% of the water phase.

44. The topical composition of any one of Claims 19-43, wherein the conditioning agent comprises at least one of isododecane, isohexadecane, Botanisil GB-21, and Botanisil GB-41.

45. The topical composition of any one of Claim 19-44, wherein the conditioning agent is combined with at least one of dimethicone or a dimethicone crossypolymer.

46. The topical composition of any one of Claims 19-45, wherein the conditioning agent comprises between about 5.00% to about 70.00% of the anhydrous phase.

47. The topical composition of any one of Claims 19-46, wherein the anhydrous phase further comprises at least one of dimethicone, a dimethicone crosspolymer, cyclopentasiloxane, a cyclopentasiloxane blend, cyclohexasiloxane, cyclotetrasiloxane, cycloheptasiloxane, and phenyl trimethicone.

48. The topical composition of Claim 47, wherein the at least one of cyclopentasiloxane, cyclohexasiloxane, cyclotetrasiloxane, and cycloheptasiloxane comprises between about 10.00% to about 100.00%) of the anhydrous phase.

49. The topical composition of any one of Claim 19-48 wherein the spheres formed have a diameter approximately 0.5 to approximately 5 mm.

50. The topical composition of any one of Claim 19-49 wherein the spheres stay formed for at least 30 minutes.

51. The topical composition of any one of Claims 19-50 wherein the spheres stay formed for at least 1 hour.

52. The topical composition of any one of Claims 19-51 wherein the spheres stay formed for at least 2 hours.

53. The topical composition of any one of Claims 19-52 wherein the spheres stay formed for at least 8 hours.

54. The topical composition of any one of Claims 19-53 wherein the spheres stay formed for at least 6 months.

55. The topical composition of any one of Claims 19-54 wherein the spheres stay formed for at least 1 year.

56. The topical composition of any one of Claims 19-55 wherein the spheres stay formed for at least 2 years.

57. A composition configured to form spheres when agitated, the composition comprising:

(a) a water phase comprising between about 25% to about 90% of the composition, the water phase comprising:

(i) water, comprising between about 60% to about 95%,

(ii) a first gelling agent configured to alter the size and duration of the formed spheres,

(iii) a second gelling agent configured to suspend an anhydrous phase within the water phase,

(iv) a skin conditioning agent configured to enhance the penetration of the composition into the skin, and

(v) a preservative comprising between about 0.20% to about 5.00%; and

(b) the anhydrous phase comprising between about 10% to about 75% of the composition.

58. The composition of Claim 57, wherein the first gelling agent comprises sclerotium gum and comprising between about 0.10% to about 1.50% of the water phase.

59. The composition of any one of Claim 57-58, wherein the second gelling agent comprises xanthan gum and comprising between about 0.10% to about 2.00% of the water phase.

60. The composition of any one of Claims 57-59, wherein the skin conditioning agent comprises at least one of pentylene glycol, butylene glycol, and another water soluble skin conditioning agent and comprising between about 1.00% to about 5.00% of the water phase.

61. The composition of any one of Claims 57-60, wherein the anhydrous phase comprises a conditioning agent configured to set the size and duration of the formed spheres, the conditioning agent comprising at least one of isododecane, isohexadecane, Botanisil GB- 21, and Botanisil GB-41, and comprising between about 5.00% to about 70.00% of the anhydrous phase.

62. The composition of Claim 57, wherein the water phase has a pH between about 3.5 to about 8.0.

63. The composition of any one of Claims 57-62, wherein the water phase has a viscosity between about 500 to about 15,000 cps.

64. The composition of any one of Claims 57-63, wherein the anhydrous phase has a viscosity between about 50 to about 10,000 cps

65. The composition of any one of Claims 57-64, the composition further including a complexion brightener.

66. The composition of Claim 65, wherein the complexion brightener comprises at least one of neurocap, brightenyl, nicainamide, specwhite plus, or copper peptide.

67. The composition of any one of Claims 57-66, the composition further including an alpha hydroxyl acid configured to help break down the spheres formed by the composition.

68. The composition of Claim 67, wherein the alpha hydroxyl acid comprises at least one of glycolic acid or lactic acid.

69. The composition of any one of Claims 67-68, wherein the alpha hydroxyl acid comprises between about 1.00% to about 20.00% of the water phase.

70. The composition of any one of Claims 67-69, the composition further including an inorganic salt configured to neutralize the glycolic acid in the composition.

71. The composition of Claim 70, wherein the inorganic salt comprises at least one of sodium hydroxide or aminom ethyl propanol.

72. The composition of Claim 71, wherein the inorganic salt comprises between about 0.20% to about 4.00% of the water phase.

73. The composition of any one of Claims 57-72, wherein the preservative comprises propanediol.

74. The composition of any one of Claims 57-73, wherein the conditioning agent is combined with at least one of dimethicone or a dimethicone crossypolymer.

75. The composition of any one of Claims 57-74, wherein the anhydrous phase further comprises at least one of dimethicone, a dimethicone crosspolymer, cyclopentasiloxane, a cyclopentasiloxane blend, cyclohexasiloxane, cyclotetrasiloxane, cycloheptasiloxane, and phenyl trimethicone.

76. The composition of Claim 75, wherein the at least one of cyclopentasiloxane, cyclohexasiloxane, cyclotetrasiloxane, and cycloheptasiloxane comprises between about 10.00% to about 100.00% of the anhydrous phase.

77. The composition of any one of Claims 57-76 wherein the spheres formed have a diameter between approximately 0.5 to approximately 5 mm.

78. The composition of any one of Claims 57-77 wherein the spheres stay formed for at least 30 minutes.

79. The composition of any one of Claims 57-78 wherein the spheres stay formed for any one of at least 1 hour, at least 2 hours, at least 8 hours, at least 6 months, at least 1 year, and at least 2 years.

80. Use of the composition according to any one of the preceding claims, for skin or hair conditioning.

Description:
SPHERE FORMING COMPOSITIONS

BACKGROUND

Field

[0001] This disclosure relates to solutions comprising two or more liquids that are normally immiscible, that can be intermixed to form spheres of one liquid encapsulated in another.

Description of the Related Art

[0002] Beauty products, such as skincare and haircare products, are frequently formulated using a mixture of oils and water which are immiscible. Common solutions involve using an emulsifier/solubilizer or creating "beads" that require encapsulation materials. However emulsifiers tend to be sticky and can create products with an undesirable tacky feel. As for the use of encapsulation materials, these can be hard to break and leave residue on the skin or hair.

SUMMARY

[0003] Disclosed herein are several embodiments of a composition made up of a plurality of immiscible liquids that, when agitated, form spheres that encapsulate at least one of the plurality of immiscible liquids.

[0004] In some embodiments, disclosed is a composition configured to form spheres when agitated. In some embodiments, the composition includes a water phase comprising between about 25% to about 90% of the composition, the water phase comprising: (i) water, comprising between about 60% to about 95%, (ii) a first gelling agent configured to alter the size and duration of the formed spheres, the first gelling agent comprising sclerotium gum and comprising between about 0.10% to about 1.50% of the water phase, (iii) a second gelling agent configured to suspend an anhydrous phase within the water phase, the second gelling agent comprising xanthan gum and comprising between about 0.10%) to about 2.00% of the water phase, (iv) a skin conditioning agent configured to enhance the penetration of the composition into the skin, the skin conditioning agent comprising at least one of pentylene glycol, butylene glycol, and another water soluble skin conditioning agent and comprising between about 1.00% to about 5.00% of the water phase, and (v) a preservative comprising between about 0.20% to about 5.00%. In some embodiments, the composition includes an anhydrous phase comprising between about 10% to about 75%) of the composition, the anhydrous phase comprising: a conditioning agent configured to set the size and duration of the formed spheres, the conditioning agent comprising at least one of isododecane, isohexadecane, Botanisil GB-21, and Botanisil GB- 41, and comprising between about 5.00%> to about 70.00%> of the anhydrous phase.

[0005] In other embodiments, the water phase has a pH between about 3.5 to about 8.0. In other embodiments, the water phase has a viscosity between about 500 to about 15,000 cps. In other embodiments, the anhydrous phase has a viscosity between about 50 to about 10,000 cps.

[0006] In other embodiments, the composition includes a complexion brightener. In other embodiments, the complexion brightener comprises at least one of neurocap, brightenyl, nicainamide, specwhite plus, or copper peptide.

[0007] In other embodiments, the composition includes an alpha hydroxyl acid configured to help break down the spheres formed by the composition. In other embodiments, the alpha hydroxyl acid comprises at least one of glycolic acid or lactic acid. In other embodiments, the alpha hydroxyl acid comprises between about 1.00%> to about 20.00% of the water phase.

[0008] In other embodiments, the composition includes an inorganic salt configured to neutralize the glycolic acid in the composition. In other embodiments, the inorganic salt comprises at least one of sodium hydroxide or aminomethyl propanol. In other embodiments, the inorganic salt comprises between about 0.20% to about 4.00% of the water phase.

[0009] In other embodiments, the preservative comprises propanediol.

[0010] In other embodiments, the conditioning agent is combined with at least one of dimethicone or a dimethicone crossypolymer.

[0011] In other embodiments, the anhydrous phase comprises at least one of dimethicone, a dimethicone crosspolymer, cyclopentasiloxane, a cyclopentasiloxane blend, cyclohexasiloxane, cyclotetrasiloxane, cycloheptasiloxane, and phenyl trimethicone. In other embodiments, at least one of cyclopentasiloxane, cyclohexasiloxane, cyclotetrasiloxane, and cycloheptasiloxane comprises between about 10.00% to about 100.00%) of the anhydrous phase.

[0012] In other embodiments, the spheres formed have a diameter between approximately 0.5 to approximately 5 mm. In other embodiments, the spheres stay formed for at least 30 minutes. In other embodiments, the spheres stay formed for at least 1 hour. In other embodiments, the spheres stay formed for at least 2 hours. In other embodiments, the spheres stay formed for at least 8 hours. In other embodiments, the spheres stay formed for at least 6 months. In other embodiments, the spheres stay formed for at least 1 year. In other embodiments, the spheres stay formed for at least 2 years.

[0013] In some embodiments, disclosed is a topical composition that is configured to form spheres when agitated. In some embodiments, the composition comprises a water phase comprising: (i) water, (ii) a first gelling agent configured to alter the size and duration of the formed spheres, (iii) a second gelling agent configured to suspend the anhydrous phase within the water phase, (iv) a skin conditioning agent configured to enhance the penetration of the composition into the skin, and (v) a preservative. In some embodiments, the composition comprises an anhydrous phase comprising: a conditioning agent configured to set the size and duration of the formed spheres.

[0014] In other embodiments, water can compose between about 60%> to about 95% of the water phase. In other embodiments, the anhydrous phase makes up between about 10%) to about 75% of the topical composition. In other embodiments, the water phase makes up between about 25% to about 90% of the topical composition. In other embodiments, the water phase has a pH between about 3.5 to about 8.0. In other embodiments, the water phase has a viscosity between about 500 to about 15,000 cps. In other embodiments, the anhydrous phase has a viscosity between about 50 to about 10,000 cps.

[0015] In other embodiments, the first gelling agent comprises sclerotium gum. In other embodiments, the sclerotium gum comprises between about 0.10% to about 1.50% of the water phase. In other embodiments, the second gelling agent comprises xanthan gum. In other embodiments, the xanthan gum comprises between about 0.10% to about 2.00% of the water phase.

[0016] In other embodiments, the skin conditioning agent is water soluble. In other embodiments, the skin conditioning agent comprises at least one of pentylene glycol, butylene glycol, and another water soluble skin conditioning agent. In other embodiments, the skin conditioning agent comprises between about 1.00%> to about 5.00%> of the water phase.

[0017] In other embodiments, the composition includes a complexion brightener. In other embodiments, the complexion brightener comprises at least one of neurocap, brightenyl, nicainamide, specwhite plus, or copper peptide.

[0018] In other embodiments, the composition includes an alpha hydroxyl acid configured to help break down the spheres formed by the topical composition. In other embodiments, the alpha hydroxyl acid comprises at least one of glycolic acid or lactic acid. In other embodiments, the alpha hydroxyl acid comprises between about 1.00%> to about 20.00% of the water phase.

[0019] In other embodiments, the composition includes an inorganic salt configured to neutralize the glycolic acid in the topical composition. In other embodiments, the inorganic salt comprises at least one of sodium hydroxide or aminomethyl propanol. In other embodiments, the inorganic salt comprises between about 0.20% to about 4.00% of the water phase.

[0020] In other embodiments, the preservative is water soluble and comprises between about 0.20% to about 1.00% of the water phase. In other embodiments, the preservative comprises propanediol. In other embodiments, the propanediol comprises between about 1.00% to about 5.00% of the water phase.

[0021] In other embodiments, the conditioning agent comprises at least one of isododecane, isohexadecane, Botanisil GB-21, and Botanisil GB-41. In other embodiments, the conditioning agent is combined with at least one of dimethicone or a dimethicone crossypolymer. In other embodiments, the conditioning agent comprises between about 5.00%) to about 70.00% of the anhydrous phase. [0022] In other embodiments, the anhydrous phase further comprises at least one of dimethicone, a dimethicone crosspolymer, cyclopentasiloxane, a cyclopentasiloxane blend, cyclohexasiloxane, cyclotetrasiloxane, cycloheptasiloxane, and phenyl trimethicone. In other embodiments, the at least one of cyclopentasiloxane, cyclohexasiloxane, cyclotetrasiloxane, and cycloheptasiloxane comprises between about 10.00% to about 100.00% of the anhydrous phase.

[0023] In other embodiments, the spheres formed have a diameter approximately 0.5 to approximately 5 mm. In other embodiments, the spheres stay formed for at least 30 minutes. In other embodiments, the spheres stay formed for at least 1 hour. In other embodiments, the spheres stay formed for at least 2 hours. In other embodiments, the spheres stay formed for at least 8 hours. In other embodiments, the spheres stay formed for at least 6 months. In other embodiments, the spheres stay formed for at least 1 year. In other embodiments, the spheres stay formed for at least 2 years.

[0024] In some embodiments, the disclosed sphere forming composition is configured for carrying keratin materials, in particular for the skin. In some embodiments, the disclosed composition is surfactant free and is configured for easy application on the skin. The disclosed composition can have good cosmetic properties, particularly in terms of texture. In some embodiments, the disclose composition is kinetically stable, (e.g. room temperature, or a high temperature such as 50°C). In some examples, the disclosed composition is configured to suspend oils in an aqueous gel and avoids the need for any added surfactants. This can result in no added residue on the skin.

BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Various embodiments are depicted in the accompanying drawings for illustrative purposes. The drawings should not be interpreted as limiting the scope of this disclosure. Various features of different disclosed embodiments can be combined to form additional embodiments, which are part of this disclosure. Any one feature, or any combination of features, of any embodiment can be included in any other embodiment.

[0026] Figure 1 illustrates three non-limiting embodiments of a sphere forming composition according to several embodiments disclosed herein comprising a 75% water phase and a 25% anhydrous phase resulting in formation of spheres ranging between 2 mm to 4 mm. Each of the three compositions differs in the color ingredient it contains.

[0027] Figure 2 illustrates three non-limiting embodiments of a sphere forming composition comprising a 65% water phase and a 35% anhydrous phase resulting in formation of spheres ranging between 3 mm to 5 mm. The composition in the leftmost vial separates into two layers after 30 minutes, the composition in the middle vial experiences no separation, and the composition in the rightmost vial separates after two (2) hours.

[0028] Figure 3 illustrates an additional embodiment of a sphere forming composition comprising a 65% water phase and a 35% anhydrous phase resulting in formation of spheres ranging between 2 mm to 4 mm. The right vial illustrates the composition after is has been agitated. The left vial illustrates the embodiment of the composition after two (2) hours have elapsed.

DETAILED DESCRIPTION

Overview

[0029] Many cosmetic products involve active ingredients that can be either water-soluble or oil-soluble. In order for such products to be formulated, these normally immiscible liquids need to be intermixed to ensure the active ingredients are evenly distributed throughout the product. Existing solutions to intermix immiscible liquids, such as oil/silicone and water, involve the use of emulsifiers or solubilizers (e.g. Carbomer, Cetaryl, Alcohol, Emulsifying Wzx-NF, Lecithin, PEG-20 Stearate, Propylene Glycol, Polysorbate 20, or PEG 40 Hydrogentated Castor Oil). However, as noted above, emulsifiers can be sticky and create products with an undesirable tacky feel.

[0030] Other existing solutions include creating "beads" that encapsulate one liquid within another. However, the creation of "beads" require encapsulation materials that can be hard to break and leave residue where applied.

[0031] According to several embodiments, disclosed is a composition that begins as a multi-phase structure including a plurality of immiscible liquids that, upon agitation, encapsulates and suspends one of the plurality of liquids (e.g., in spheres). In some embodiments, the composition includes a water phase and an anhydrous (for example, oil or silicone) phase. As will be discussed in more detail below, a thickener can be added to the water phase to allow the water molecules to encapsulate the anhydrous phase into spheres. As used herein, the term "spheres" shall be given its ordinary meaning and shall also refer to generally spherical or spheroid shapes with an outer surface that encapsulates a second material or phase. Shapes that are globular, ball-shaped, orb-shaped, ovoid or otherwise shaped in which an outer surface defines an interior volume filled, at least in part, by another material shall also fall within the term "sphere".

[0032] The formed spheres are stable and can be configured to last for specific durations depending on modifications to the formula. In some embodiments, the spheres can release back into the multi-phase structure after a specific period of time. For example, by adjusting the ratio of thickener in the water phase and the ratio of oil or silicone to water, the size and duration of the spheres formed can be controlled.

[0033] As well the formed spheres can be customized in terms of the benefits applied to the skin or hair of the user. In some embodiments, the composition can be optimized depending on the application of the product - for example the composition for a haircare formula may differ from the composition for a skincare formula.

Benefits

[0034] In some embodiments, the formulations disclosed herein can act as a vehicle or a base formulation to which additional ingredients can be added. The disclosed formulation, in addition to enabling the intermixing of two immiscible liquids, also provides a number of additional benefits.

[0035] For example, the composition can have a lightweight serum texture without any tacky residue or film. As noted above, many cosmetic products include an emulsifier to intermix immiscible liquids such as oil or silicone and water. However, emulsifiers tend to be sticky and can create products with an undesirable tacky feel. Other technologies that create "beads" require encapsulation materials that can leave residue on the skin or hair when broken. Furthermore, because the disclosed does not contain an emulsifier, the oil or silicone phase is captured is a larger quantities (e.g. in spheres) when compared to an emulsion. The larger spheres and absence of an emulsifier gives the product a better feel when applied to skin. [0036] In some embodiments, the compositions disclosed herein can contain a high percentage of oil or silicone yet will have a low viscosity. By comparison, an emulsified water and oil or silicone formula will generally need to have a high viscosity with a high oil or silicone content. This low viscosity can allow the anhydrous phase (for example, oil or silicone) to better mix with the water phase. In some embodiments, the lower viscosity can allow the formula create larger spheres when the mixture is agitated. The larger spheres can give the agitated composition a better appearance. In some embodiments, the larger spheres can help to make the composition easier to dispense.

[0037] The formed spheres according to several embodiments disclosed herein can also be visually distinctive. In some embodiments, coloring can be added into the water phase or the anhydrous (for example, oil or silicone) phase to create an attractive appearance to the composition. As noted above, in some embodiments, the size and/or duration (e.g., longevity) of the formed spheres can be controlled by modifications to the formula. In some embodiments, the formed spheres can range from about 0.5 mm to about 5.0 mm in size. In some examples, the size of the formed spheres can be controlled by changes in the ratios of certain ingredients when combined with dimethicone or a dimethicone crosspolymer. In some embodiments, the dimethicone or dimethicone crosspolymer can help to set the size and duration of the formed spheres. In some embodiments, the spheres can remain formed in the composition for an indefinite period of time. In some embodiments, the composition will not separate (and the spheres will remain formed) for up to about 30 minutes, about 1 hour, about 2 hours, about 8 hours, about 6 months, about 1 year, about 2 years, etc. Figure 3 illustrates a non-limiting example of a composition where the spheres are configured to remain formed for two (2) hours. As shown, the vial on the right illustrates the composition shortly after it has been agitated with formed spheres ranging between 2 mm and 4 mm. The vial on the left illustrates the composition after two (2) hours have elapsed, and the spheres have the opportunity to separate out into the water phase and the anhydrous phase. In some examples, the formed spheres can remain in the composition by increasing a thickener added in the water phase.

[0038] The ability to intermix two immiscible liquids - such as water and oil or silicone - enable a greater range of active ingredients to be used in the composition. In some embodiments, the disclosed composition allows formulators to use a greater range of active ingredients because both water soluble and oil or silicone soluble active ingredients can be included. In some examples, active ingredients can be loaded into both the water and oil or silicone phases in high concentrations.

[0039] The formation of encapsulated spheres can provide formulators with a vehicle for the easy and economical formulation of compositions. In some embodiments, compounding will not require heat or agitation - processes that can diminish the efficacy of active ingredients. Furthermore, because water-active ingredients stay in the water phase while the oil/silicone-soluble ingredients stay in the anhydrous phase, they are not mixed together or react to each other. As many oil soluble active ingredients are unstable in water or react with the water phase to affect the active ingredient's potency and availability, the disclosed compositions can help to keep active ingredients separated. This can create a delivery system that preserves the full efficacy of the active ingredients in each of the different phases.

[0040] In some embodiments, the composition can easily penetrate the skin to optimize skin treatment benefits. For example, the composition can brighten complexion and boost collagen activity for more supple skin, and a renewed appearance and/or feel. In some embodiments, ingredients can include Neurocap, Brightenyl, Nicainamide, SpecWhite Plus, and Copper Peptide. In some embodiments, the composition can be configured for use on all skin types - even skin with acne and/or sensitive skins - and can be layered under other topical compositions.

Example Formulation

[0041] In some embodiments, the multi-phase composition can include a water phase and an anhydrous phase. In some embodiments, the percent of the water phase can range between 5%-90% and the percent of the anhydrous phase can range between 5%-90%. In some embodiments, the ratio between the water phase and the anhydrous phase can be about 10: 1, about 5: 1, about 2.5: 1, about 1 : 1, about 1 :2.5, about 1 :5, about 1 : 10. In some embodiments, the composition can range from a 10% anhydrous phase and a 90% water phase to a 75% anhydrous phase and a 25% water phase. [0042] In some embodiments, the water phase can range, depending on the composition, from clear to a slightly semi-viscous serum. The coloration of the water phase can range from straw to green colored, however any color can be used. In some embodiments, the pH level of the water phase can have a pH that ranges from 3.5-8.0. For example, the water phase can have a pH of about 3.5 to about 3.6, about 3.6 to about 3.7, about 3.7 to about 3.8, about 3.8 to about 3.9, about 3.9 to about 4.0, about 4.0 to about 4.1, about 4.1 to about 4.2, about 4.2 to about 4.3, about 4.3 to about 4.4, about 4.4 to about 4.5, about 4.5 to about 4.6, about 4.6 to about 4.7, about 4.7 to about 4.8, about 4.8 to about 4.9, about 4.9 to about 5.0, about 5.0 to about 5.1, about 5.1 to about 5.2, about 5.2 about 5.3, about 5.3 to about 5.4, about 5.4 to about 5.5, about 5.5 to about 5.6, about 5.6 to about 5.7, about 5.7 to about 5.8, about 5.8 to about 5.9, about 5.9 to about 6.0, about 6.0 to about 6.1, about 6.1 to about 6.2, about 6.2 to about 6.3, about 6.3 to about 6.4, about 6.4 to about 6.5, about 6.5 to about 6.6, about 6.6 to about 6.7 about 6.7 to about 6.8, about 6.8 to about 6.9, about 6.9 to 7.0, about 7.0 to about 7.1, about 7.1 to about 7.2, about 7.2 to about 7.3, about 7.3 to about 7.4, about 7.4 to about 7.5, about 7.5 to about 7.6, about 7.6 to about 7.7, about 7.7 to about 7.8, about 7.9, about 7.9 to about 8, and overlapping ranges thereof.

[0043] In some embodiments, the viscosity of the water phase can range between 500-15,000 cps. For example, the water phase can have a viscosity of about 500 cps to about 1,000 cps, about 1,000 cps to about 1,500 cps, about 1,500 cps to about 2,000 cps, about 2,000 cps to about 2,500 cps, about 2,500 cps to about 3,000 cps, about 3,000 cps to about 3,500 cps, about 3,500 cps to about 4,000 cps, about 4,000 cps to about 4,500 cps, about 4,500 cps to about 5,000 cps, about 5,000 cps to about 5,500 cps, about 5,500 cps to about 6,000 cps, about 6,000 cps to about 6,500 cps, about 6,500 cps to about 7,000 cps, about 7,000 cps to about 7,500 cps, about 7,500 cps to about 8,000 cps, about 8,000 cps to about 8,500 cps, about 8,500 cps to about 9,000 cps, about 9,000 cps to about 9,500 cps, about 9,500 cps to about 10,000 cps, about 10,000 cps to about 10,500 cps, about 10,500 cps to about 11,000 cps, about 11,000 cps to about 11,500 cps, about 11,500 cps to about 12,000 cps, about 12,000 cps to about 12,500 cps, about 12,500 cps to about 13,000 cps, about 13,000 cps to about 13,500 cps, about 13,500 cps to about 14,000 cps, about 14,000 cps to about 14,500 cps, about 14,500 cps to about 15,000 cps, and overlapping ranges thereof. [0044] In some embodiments, the anhydrous phase can range, depending on the composition, from clear to a slightly hazy serum. The coloration of the anhydrous phase can range from a straw to a clear color, however any color can be used. In some embodiments, the viscosity of the anhydrous phase can range between 50-10,000 cps. For example, the anhydrous phase can have a viscosity of about 50 cps to about 100 cps, about 100 cps to about 200 cps, about 200 cps to about 300 cps, about 300 cps to about 400 cps, about 400 cps to about 500 cps, about 500 cps to about 1,000 cps, about 1,000 cps to about 1,500 cps, about 1,500 cps to about 2,000 cps, about 2,000 cps to about 2,500 cps, about 2,500 cps to about 3,000 cps, about 3,000 cps to about 3,500 cps, about 3,500 cps to about 4,000 cps, about 4,000 cps to about 4,500 cps, about 4,500 cps to about 5,000 cps, about 5,000 cps to be about 5,500 cps, about 5,500 cps to be about 6,000 cps, about 6,000 cps to about 6,500 cps, about 6,500 cps to about 7,000 cps, about 7,000 cps to about 7,500 cps, about 7,500 cps to about 8,000 cps, about 8,000 cps to about 8,500 cps, about 8,500 cps to about 9,000 cps, about 9,000 cps to about 9,500 cps, about 9,500 cps to about 10,000 cps, and overlapping ranges thereof.

[0045] In addition to a sufficient quantity of deionized water, the formulation of the water phase can include any of the following ingredients. In some embodiments, water can compose between 60%-95% of the water phase.

[0046] Sclerotium gum is a natural polysaccharide polymer that can act as a rheology modifier and gelling agent. In some embodiments, sclerotium gum can gel the water phase, thereby permitting the anhydrous phase to be suspended within spheres. In some embodiments, the sclerotium gum can aid the formulation of the spheres and help to set their size and duration. Sclerotium gum can be sold under the trade name Amigel and is available from Alban Muller International. In some embodiments, the water phase includes a percentage of sclerotium gum that ranges from about 0.10%-1.50%. In some embodiments, the percentage of sclerotium gum in the water phase can be about 0.10% to about 0.15%, about 0.15% to about 0.20%, about 0.20% to about 0.25%, about 0.25% to about 0.30%, about 0.30% to about 0.35%, about 0.35% to about 0.40%, about 0.40% to about 0.45%, about 0.45% to about 0.50%, about 0.50% to about 0.55%, about 0.55% to about 0.60%, about 0.60% to about 0.65%, about 0.65% to about 0.70%, about 0.70% to about 0.75%, about 0.75% to about 0.80%, about 0.80% to about 0.85%, about 0.85% to about 0.90%, about 0.90% to about 0.95%, about 0.95% to about 1.00%, about 1.00% to about 1.05%, about 1.05% to about 1.10%, about 1.10% to about 1.15%, about 1.15% to about 1.20%, about 1.20% to about 1.25%, about 1.25% to about 1.30%, about 1.30% to about 1.35%, about 1.35% to about 1.40%, about 1.40% to about 1.45%, about 1.45% to about 1.50%, and overlapping ranges thereof.

[0047] The water phase can also include xanthan gum. Xanthan gum is a natural polysaccharide polymer that can act as rheology modifier and gelling agent. In some embodiments, xanthan gum can gel the water phase, thereby permitting the anhydrous phase to be suspended within spheres. In some embodiments, the water phase includes a percentage of xanthan gum that ranges from about 0.10%-2.00%. In some embodiments, the percentage of xanthan gum in the water phase can be about 0.10% to about 0.20%, about 0.20% to about 0.30%, about 0.30% to about 0.40%, about 0.40% to about 0.50%, about 0.50% to about 0.60%, about 0.60% to about 0.70%, about 0.70% to about 0.80%, about 0.80% to about 0.90%, about 0.90% to about 1.00%, about 1.00% to about 1.10%, about 1.10% to about 1.20%, about 1.20% to about 1.30%, about 1.30% to about 1.40%, about 1.40% to about 1.50%, about 1.50% to about 1.60%, about 1.60% to about 1.70%, about 1.70% to about 1.80%, about 1.80% to about 1.90%, about 1.90% to about 2.00%, or overlapping ranges thereof.

[0048] Pentylene glycol can be included in the water phase to serve as a skin conditioning agent. Pentylene glycol can improve the moisturizing of skin and enhance the penetration of other ingredients. Pentylene glycol can be sold under the trade name Hydrolite 5 and is available from Symrise AG. In some embodiments, instead of pentylene glycol, butylene glycol or another water soluble skin conditioning ingredient can be used. In some embodiments, the composition does not include a skin conditioning agent. In some embodiments, the water phase includes a percentage of pentylene glycol that ranges from 1.00%-5.00%. In some embodiments, the percentage of pentylene glycol in the water phase can be about 1.00% to about 1.10%, about 1.10% to about 1.20%, about 1.20% to about 1.30%, about 1.30% to about 1.40%, about 1.40% to about 1.50%, about 1.50% to about 1.60%, about 1.60% to about 1.70%, about 1.70% to about 1.80%, about 1.80% to about 1.90%, about 1.90% to about 2.00%, about 2.00% to about 2.10%, about 2.10% to about

2.20%, about 2.20% to about 2.30%, about 2.30% to about 2.40%, about 2.40% to about

2.50%, about 2.50% to about 2.60%, about 2.60% to about 2.70%, about 2.70% to about

2.80%, about 2.80% to about 2.90%, about 2.90% to about 3.00%, about 3.00% to about

3.10%, about 3.10% to about 3.20%, about 3.20% to about 3.30%, about 3.30% to about

3.40%, about 3.40% to about 3.50%, about 3.50% to about 3.60%, about 3.60% to about

3.70%, about 3.70% to about 3.80%, about 3.80% to about 3.90%, about 3.90% to about

4.00%, about 4.00% to about 4.10%, about 4.10% to about 4.20%, about 4.20% to about

4.30%, about 4.30% to about 4.40%, about 4.40% to about 4.50%, about 4.50% to about

4.60%, about 4.60% to about 4.70%, about 4.70% to about 4.80%, about 4.80% to about

4.90%), about 4.90% to about 5.00%, or overlapping ranges thereof.

[0049] In some embodiments, the water phase includes glycolic acid. Glycolic acid is an alpha hydroxyl acid that can aid cell turnover and produce skin lightening. Glycolic acid can be included to break down the spheres and return the product to two separate phases more quickly. Glycolic acid can be sold under the trade name Glypure L-70 and is available from DuPont USA. In some embodiments, the glycolic acid in the composition can be replaced by any other alpha hydroxyl acid, such as lactic acid. In some embodiments, the water phase includes a percentage of glycolic acid that ranges from about

I .00%-20.00%. In some embodiments, the percentage of glycolic acid in the water phase can be about 1.00% to about 1.50%, about 1.50% to about 2.00%, about 2.00% to about 2.50%, about 2.50% to about 3.00%, about 3.00% to about 3.50%, about 3.50% to about 4.00%, about 4.00% to about 4.50%, about 4.50% to about 5.00%, about 5.00% to about 5.50%, about 5.50% to about 6.00%, about 6.00% to about 6.50%, about 6.50% to about 7.00%, about 7.00% to about 7.50%, about 7.50% to about 8.00%, about 8.00% to about 8.50%, about 8.50% to about 9.00%, about 9.00% to about 9.50%, about 9.50% to about 10.00%, about 10.00% to about 10.50%, about 10.50% to about 11.00%, about 11.00% to about

I I .50%, about 11.50% to about 12.00%, about 12.00% to about 12.50%, about 12.50% to about 13.00%, about 13.00% to about 13.50%, about 13.50% to about 14.00%, about 14.00% to about 14.50%, about 14.50% to about 15.00%, about 15.00% to about 15.50%, about 15.50% to about 16.00%, about 16.00% to about 16.50%, about 16.50% to about 17.00%, about 17.00% to about 17.50%, about 17.50% to about 18.00%, about 18.00% to about 18.50%, about 18.50% to about 19.00%, about 19.00% to about 19.50%, about 19.50% to about 20.00%), or overlapping ranges thereof.

[0050] In some embodiments, the water phase can include sodium hydroxide. Sodium hydroxide is an inorganic salt that can be used to adjust the pH of the formulation. Sodium hydroxide can be included to neutralize the glycolic acid in the composition. Sodium hydroxide can be sold under the trade name Sodium Hydroxide, Pellets, F and is available from Univar. In some embodiments, aminomethyl propanol can be used in place of sodium hydroxide. In some embodiments, the water phase includes a percentage of sodium hydroxide that ranges from about 0.20%-4.00%. In some embodiments, the percentage of sodium hydroxide in the water phase can be about 0.20% to about 0.30%, about 0.30% to about 0.40%, about 0.40% to about 0.50%, about 0.50% to about 0.60%, about 0.60% to about 0.70%, about 0.70% to about 0.80%, about 0.80% to about 0.90%, about 0.90% to about 1.00%, about 1.00% to about 1.10%, about 1.10% to about 1.20%, about 1.20% to about 1.30%, about 1.30% to about 1.40%, about 1.40% to about 1.50%, about 1.50% to about 1.60%, about 1.60% to about 1.70%, about 1.70% to about 1.80%, about 1.80% to about 1.90%, about 1.90% to about 2.00%, about 2.00% to about 2.10%, about 2.10% to about 2.20%, about 2.20% to about 2.30%, about 2.30% to about 2.40%, about 2.40% to about 2.50%, about 2.50% to about 2.60%, about 2.60% to about 2.70%, about 2.70% to about 2.80%, about 2.80% to about 2.90%, about 2.90% to about 3.00%, about 3.00% to about 3.10%, about 3.10% to about 3.20%, about 3.20% to about 3.30%, about 3.30% to about 3.40%, about 3.40% to about 3.50%, about 3.50% to about 3.60%, about 3.60% to about 3.70%, about 3.70% to about 3.80%. , about 3.80% to about 3.90%, about 3.90% to about 4.00%), or overlapping ranges thereof.

[0051] The water phase can also include propanediol. Propanediol can be included in the water phase as a solvent or as a preservative. In some embodiments, propanediol can help to prevent or retard microbial growth, and therefore protect the composition - for example when used in a cosmetic product - from spoilage. Propanediol can be sold under the trade name Zemea and is available from DuPont USA. In some embodiments, the water phase includes a percentage of propanediol from about 1.00%- 5.00%. In some embodiments, the percentage of propanediol in the water phase can be about 1.00% to about 1.10%, about 1.10% to about 1.20%, about 1.20% to about 1.30%, about 1.40%, about 1.40% to about 1.50%, about 1.50% to about 1.60%, about 1.60% to about 1.70%, about 1.70% to about 1.80%, about 1.80% to about 1.90%, about 1.90% to about 2.00%, about 2.00% to about 2.10%, about 2.10% to about 2.20%, about 2.20% to about 2.30%, about 2.30% to about 2.40%, about 2.40% to about 2.50%, about 2.50% to about 2.60%, to about 2.60% to about 2.70%, about 2.70% to about 2.80%, about 2.80% to about 2.90%, about 2.90% to about 3.00%, about 3.00% to about 3.10%, about 3.10% to about 3.20%, about 3.20% to about 3.30%, about 3.30% to about 3.40%, about 3.40% to about 3.50%, about 3.50% to about 3.60%, about 3.60% to about 3.70%, about 3.70% to about 3.80%, about 3.80% to about 3.90%, about 3.90% to about 4.00%, about 4.00% to about 4.10%, about 4.10% to about 4.20%, about 4.20% to about 4.30%, about 4.30% to about 4.40%, about 4.40% to about 4.50%, about 4.50% to about 4.60%, about 4.60% to about 4.70%, about 4.70% to about 4.80%, about 4.80% to about 4.90%, about 4.90% to about 5.00%), or overlapping ranges thereof.

[0052] In some embodiments, the water phase can also include a water-soluble preservative. The water-soluble preservative can be included as a water soluble preservative. A water soluble preservative can avoid the need for a solvent in order to solubilize the preservative in the water phase. In some embodiments, the water-soluble preservative is a sodium benzoate that can be available from Univar. In some embodiments, the water-soluble preservative is a potassium sorbate that can be available from Univar. In some embodiments any water soluble preservative can be used. In some embodiments, the water-soluble preservative has the trade name Argan-O-Cide 7A that is available from Argan. In some embodiments, the water-soluble preservative is composed of water, lactic acid, malic acid, citric acid, glycolic acid, ascorbic acid, tartaric acid, gluconic acid, and propanediol. In some embodiments, the water-soluble preservative has the trade name Geogard Ultra that is available for sale from Lonza Group Ltd. In some embodiments, the water-soluble preservative is composed of sodium benzoate and gluconolcatone. In some embodiments, the water phase includes a percentage of water-soluble preservative from about 0.20%- 1.00%. In some embodiments, the percentage of water-soluble preservatives in the water phase can be about 0.20% to about 0.22%, about 0.22% to about 0.24%, about 0.24% to about 0.26% about 0.26% to about 0.28%, about 0.28% to about 0.30%, about 0.30% to about 0.32%, about 0.32% to about 0.34%, about 0.34% to about 0.36%, about 0.36% to about 0.38%, about 0.38% to about 0.40%, about 0.40% to about 0.42%, about 0.42% to about 0.44%, about 0.44% to about 0.46%, about 0.46% to about 0.48%, about 0.48% to about 0.50%, about 0.50% to about 0.52%, about 0.52% to about 0.54%, about 0.54% to about 0.56%, to about 0.56% to about 0.58%, about 0.58% to about 0.60%, about 0.60% to about 0.62%, about 0.62% to about 0.64%, about 0.64% to about 0.66%, about 0.66% to about 0.68%, about 0.68% to about 0.70%, about 0.70% to about 0.72%, about 0.72% to about 0.74%, about 0.74% to about 0.76%, about 0.76% to about 0.78%, about 0.78% to about 0.80%, about 0.80% to about 0.82%. about 0.82% to about 0.84%, about 0.84% to about 0.86%, about 0.86% to about 0.88%, about 0.88% to about 0.90%, about 0.90% to about 0.92%, about 0.92% to about 0.94%, about 0.94% to about 0.96%, about 0.96% to about 0.98%, about 0.98%) to about 1.00%, or overlapping ranges thereof.

[0053] The formulation of the anhydrous phase can include any of the following ingredients. In some embodiments, the anhydrous phase can also include isododecane. Isododecane can be included in the anhydrous phase to help maintain the soft, smooth, and pliable appearance of the skin. In some embodiments, when the isododecane is combined with dimethicone or dimethicone crosspolymer, it can help to set the size and the duration the spheres are formed. In some embodiments, isododecane can provide the composition with a lighter feel and better performance when applied to the skin. Isododecane can be sold under the trade name Armesil 12C and is available from Argan. In some embodiments, isohexadecane can be used in place of isododecane. In some embodiments, the anhydrous phase includes a percentage of isododecane from about 5.00%-70.00%. In some embodiments, the percentage of the isododecane in the anhydrous phase can be about 5.00% to about 6.00%, about 6,00% to about 7.00%, about 7.00% to about 8.00%, about 8.00% to about 9.00%, about 9.00% to about 10.00%, about 10.00% to about 11.00%, about 11.00% to about 12.00%, about 12.00% to about 13.00%, about 13.00% to about 14.00%, about 14.00% to about 15.00%, about 15.00% to about 16.00%, about 16.00% to about 17.00%, about 17.00% to about 18.00%, about 18.00 to about 19.00%, about 19.00%, about 19.00% to about 20.00%, about 20.00% to about 21.00%, about 21.00% to about 22.00%, about 22.00% to about 23.00%, about 23.00% to about 24.00%, about 24.00% to about 25.00%, about 25.00% to about 26.00%, about 26.00% to about 27.00%, about 27.00% to about 28.00%, about to 28.00 to about 29.00%, about 29.00% to about 30.00%, about 30.00% to about 31.00%, about 31.00% to about 32.00%, about 32.00% to about 33.00%, about 33.00% to about 34.00%, about 34.00% to about 35.00%, about 35.00% to about 36.00%, about 36.00% to about 37.00%, about 37.00% to about 38.00%, about 38.00% to about 39.00%, about 39.00% to about 40.00%, about 40.00% to about 41.00%, about 41.00% to about 42.00%, about 42.00% to about 43.00%, about 43.00% to about 44.00%, about 44.00% to about 45.00%, about 45.00% to about 46.00%, about 46.00% to about 47.00%, about 47.00% to about 48.00%, about 48.00% to about 49.00%, about 49.00% to about 50.00%, about 50.00% to about 51.00%, about 51.00% to about 52.00%, about 52.00% to about 53.00%, about 53.00% to about 54.00%, about 54.00% to about 55.00%, about 55.00% to about 56.00%, about 56.00% to about 57.00%, about 57.00% to about 58.00%, about 58.00% to about 59.00%, about 59.00% to about 60.00%, about 60.00% to about 61.00%, about 61.00% to about 62.00%, about 62.00% to about 63.00%, about 63.00% to about 64.00%, about 64.00% to about 65.00%, about 65.00% to about 66.00%, about 66.00% to about 67.00%, about 67.00% to about 68.00%, about 68.00% to about 69.00%, about 69.00% to about 70.00%, or overlapping ranges thereof.

[0054] The anhydrous phase can also include a combination of isododecane and dimethicone crosspolymer that is sold under the trade name Botanisil GB-21 and is available from Botanigenics. Botanisil GB-21 can be included in the anhydrous phase to help maintain the soft, smooth, and pliable appearance of skin. In some embodiments, when Botanisil GB- 21 is combined with isododecane, it can help to set the size and duration of the formed spheres. In some embodiments, Botanisil GB-21 can be added to provide shine and improve the look and feel of the composition upon application on the skin. In some embodiments, the anhydrous phase can include a percentage of Botanisil GB-21 that ranges from about 5.00%- 70.00%). In some embodiments, the percentage of Botanisil GB-21 in the anhydrous phase can be about 5.00% to about 6.00%, about 6,00% to about 7.00%, about 7.00% to about 8.00%, about 8.00% to about 9.00%, about 9.00% to about 10.00%, about 10.00% to about 11.00%, about 11.00% to about 12.00%, about 12.00% to about 13.00%, about 13.00% to about 14.00%, about 14.00% to about 15.00%, about 15.00% to about 16.00%, about 16.00% to about 17.00%, about 17.00% to about 18.00%, about 18.00 to about 19.00%, about 19.00%, about 19.00% to about 20.00%, about 20.00% to about 21.00%, about 21.00% to about 22.00%, about 22.00% to about 23.00%, about 23.00% to about 24.00%, about 24.00% to about 25.00%, about 25.00% to about 26.00%, about 26.00% to about 27.00%, about 27.00% to about 28.00%, about to 28.00 to about 29.00%, about 29.00% to about 30.00%, about 30.00% to about 31.00%, about 31.00% to about 32.00%, about 32.00% to about 33.00%, about 33.00% to about 34.00%, about 34.00% to about 35.00%, about 35.00% to about 36.00%, about 36.00% to about 37.00%, about 37.00% to about 38.00%, about 38.00% to about 39.00%, about 39.00% to about 40.00%, about 40.00% to about 41.00%, about 41.00% to about 42.00%, about 42.00% to about 43.00%, about 43.00% to about 44.00%, about 44.00% to about 45.00%, about 45.00% to about 46.00%, about 46.00% to about 47.00%, about 47.00% to about 48.00%, about 48.00% to about 49.00%, about 49.00% to about 50.00%, about 50.00% to about 51.00%, about 51.00% to about 52.00%, about 52.00% to about 53.00%, about 53.00% to about 54.00%, about 54.00% to about 55.00%, about 55.00% to about 56.00%, about 56.00% to about 57.00%, about 57.00% to about 58.00%, about 58.00% to about 59.00%, about 59.00% to about 60.00%, about 60.00% to about 61.00%, about 61.00% to about 62.00%, about 62.00% to about 63.00%, about 63.00% to about 64.00%, about 64.00% to about 65.00%, about 65.00% to about 66.00%, about 66.00% to about 67.00%, about 67.00% to about 68.00%, about 68.00% to about 69.00%, about 69.00%) to about 70.00%, or overlapping ranges thereof.

[0055] In some embodiments, the anhydrous phase can also include a combination of dimethicone and dimethicone crosspolymer that is sold under the trade name Botanisil GB-41 and is available from Botanigenics. Botanisil GB-41 can be included in the anhydrous phase to help maintain the soft, smooth, and pliable appearance of skin. In some embodiments, when Botanisil GB-21 is combined with isododecane, it can help to set the size and duration of the formed spheres. In some embodiments, Botanisil GB-21 can be added to provide shine and improve the look and feel of the composition upon application to the skin. In some embodiments, the anhydrous phase can include a percentage of Botanisil GB-41 that ranges from 5.00%-70.00%. In some embodiments, the percentage of Botanisil GB-41 in the anhydrous phase can be about 5.00% to about 6.00%, about 6,00% to about 7.00%, about 7.00% to about 8.00%, about 8.00% to about 9.00%, about 9.00% to about 10.00%, about 10.00% to about 11.00%, about 11.00% to about 12.00%, about 12.00% to about 13.00%, about 13.00% to about 14.00%, about 14.00% to about 15.00%, about 15.00% to about 16.00%, about 16.00% to about 17.00%, about 17.00% to about 18.00%, about 18.00 to about 19.00%, about 19.00%, about 19.00% to about 20.00%, about 20.00% to about 21.00%, about 21.00% to about 22.00%, about 22.00% to about 23.00%, about 23.00% to about 24.00%, about 24.00% to about 25.00%, about 25.00% to about 26.00%, about 26.00% to about 27.00%, about 27.00% to about 28.00%, about to 28.00 to about 29.00%, about 29.00% to about 30.00%, about 30.00% to about 31.00%, about 31.00% to about 32.00%, about 32.00% to about 33.00%, about 33.00% to about 34.00%, about 34.00% to about 35.00%, about 35.00% to about 36.00%, about 36.00% to about 37.00%, about 37.00% to about 38.00%, about 38.00% to about 39.00%, about 39.00% to about 40.00%, about 40.00% to about 41.00%, about 41.00% to about 42.00%, about 42.00% to about 43.00%, about 43.00% to about 44.00%, about 44.00% to about 45.00%, about 45.00% to about 46.00%, about 46.00% to about 47.00%, about 47.00% to about 48.00%, about 48.00% to about 49.00%, about 49.00% to about 50.00%, about 50.00% to about 51.00%, about 51.00% to about 52.00%, about 52.00% to about 53.00%, about 53.00% to about 54.00%, about 54.00% to about 55.00%, about 55.00% to about 56.00%, about 56.00% to about 57.00%, about 57.00% to about 58.00%, about 58.00% to about 59.00%, about 59.00% to about 60.00%, about 60.00% to about 61.00%, about 61.00% to about 62.00%, about 62.00% to about 63.00%, about 63.00% to about 64.00%, about 64.00% to about 65.00%, about 65.00% to about 66.00%, about 66.00% to about 67.00%, about 67.00% to about 68.00%, about 68.00% to about 69.00%, about 69.00% to about 70.00%, or overlapping ranges thereof.

[0056] In some embodiments, the anhydrous phase can also include a dimethicone. The dimethicone can act as a moisturizer and skin barrier to hydrate and protect the skin against moisture loss. In some embodiments, dimethicone can be used to help set the size and the duration of the spheres formed. Dimethicone can, in some embodiments protect and moisturize the skin and act as a skin conditioning agent. In some embodiments, the dimethicone can be sold under trade names such as Xiameter PMX-200 Silicone Fluid 50CS, Xiameter PMX-200 Silicone Fluid lOOCS, and Xiameter PMX-200 Silicone Fluid 350 CS and is available from Dow Corning. In some embodiments, the anhydrous phase can include a percentage of dimethicone that ranges from about 10.00%- 100.00%). In some embodiments, the percentage of dimethicone in the anhydrous phase can be about 10.00% to about 12.00%, about 12.00% to about 14.00%, about 14.00% to about 16.00%, about 16.00% to about 18.00%, about 18.00% to about 20.00%, about 20.00% to about 22.00%, about 22.00% to about 24.00%, about 24.00% to about 26.00%, about 26.00% to about 28.00%, about 28.00% to about 30.00%, about 30.00% to about 32.00%, about 32.00% to about 34.00%, about 34.00% to about 36.00%, about 36.00% to about 38.00%, about 38.00% to about 40.00%, about 40.00% to about 42.00%, about 42.00% to about 44.00%, about 44.00% to about 46.00%, about 46.00% to about 48.00%, about 48.00% to about 50.00%, about 50.00% to about 52.00%, about 52.00% to about 54.00%, about 54.00% to about 56.00%, about 56.00% to about 58.00%, about 58.00% to about 60.00%, about 60.00% to about 62.00%, about 62.00% to about 24.00%, about 64.00% to about 66.00%, about 66.00% to about 68.00%, about 68.00% to about 70.00%, about 70.00% to about 72.00%, about 72.00% to about 74.00%, about 74.00% to about 76.00%, about 76.00% to about 78.00%, about 78.00% to about 80.00%, about 80.00% to about 82.00%, about 82.00% to about 84.00%, about 84.00% to about 86.00%, about 86.00% to about 88.00%, about 88.00% to about 90.00%, about 90.00%, to about 92.00%, about 92.00% to about 94.00%, about 94.00% to about 96.00%, about 96.00% to about 98.00%, about 98.00% to about 100.00%), or overlapping ranges thereof.

[0057] The anhydrous phase can also include cyclopentasiloxane. In some embodiments, the cyclopetasiloxane can be included to provide a skin conditioning agent that can impart a soft and silky feel to the skin. In some embodiments, when cyclopetasiloxane is combined with dimethicone or dimethicone crosspolymer, it can help to set the size and duration of the formed spheres. In some embodiments, the cyclopentasiloxane can be sold under the trade name Xiameter PMX-0245 Cyclopentasiloxane and is available from Dow Corning. In some embodiments, cyclohexasiloxane, cyclotetrasiloxane, or cycloheptasiloxane can also be used. In some embodiments, the anhydrous phase can include a percentage of cyclopentasiloxane that ranges from about 10.00%-100.00%. In some embodiments, the percentage of cyclopentasiloxane in the anhydrous phase can be about 10.00% to about 12.00%, about 12.00% to about 14.00%, about 14.00% to about 16.00%, about 16.00% to about 18.00%, about 18.00% to about 20.00%, about 20.00% to about 22.00%, about 22.00% to about 24.00%, about 24.00% to about 26.00%, about 26.00% to about 28.00%, about 28.00% to about 30.00%, about 30.00% to about 32.00%, about 32.00% to about 34.00%, about 34.00% to about 36.00%, about 36.00% to about 38.00%, about 38.00% to about 40.00%, about 40.00% to about 42.00%, about 42.00% to about 44.00%, about 44.00% to about 46.00%, about 46.00% to about 48.00%, about 48.00% to about 50.00%, about 50.00% to about 52.00%, about 52.00% to about 54.00%, about 54.00% to about 56.00%, about 56.00% to about 58.00%, about 58.00% to about 60.00%, about 60.00% to about 62.00%, about 62.00% to about 24.00%, about 64.00% to about 66.00%, about 66.00% to about 68.00%, about 68.00% to about 70.00%, about 70.00% to about 72.00%, about 72.00% to about 74.00%, about 74.00% to about 76.00%, about 76.00% to about 78.00%, about 78.00% to about 80.00%, about 80.00% to about 82.00%, about 82.00% to about 84.00%, about 84.00% to about 86.00%, about 86.00% to about 88.00%, about 88.00% to about 90.00%, about 90.00%, to about 92.00%, about 92.00% to about 94.00%, about 94.00% to about 96.00%, about 96.00% to about 98.00%, about 98.00% to about 100.00%, or overlapping ranges thereof.

[0058] In some embodiments, the anhydrous phase can include a cyclopentasiloxane blend. The cyclopentasiloxane blend can be included as a skin conditioning agent that can impart a soft and silky feel upon the skin. In some embodiments, when cyclopentasiloxane is combined with dimethicone or dimethicone crosspolymer, the cyclopentasiloxane can serve to set the size and duration of the formation of the spheres. In some embodiments, the cyclopentasiloxane blend is a mixture of cyclopentasiloxane and cyclohexasiloxane. In some embodiments, the cyclopentasiloxane blend can be sold under the trade name Xiameter PMX-0345 Cyclopentasiloxane Blend and is available from Dow Corning. In some embodiments, cyclohexasiloxane, cyclotetrasiloxane, or cycloheptasiloxane can also be used. In some embodiments, the anhydrous phase can include a percentage of cyclopentasiloxane blend that ranges from about 10.00%- 100.00%). In some embodiments, the percentage of cyclopentasiloxane blend in the anhydrous phase can be about 10.00% to about 12.00%, about 12.00% to about 14.00%, about 14.00% to about 16.00%, about 16.00% to about 18.00%, about 18.00% to about 20.00%, about 20.00% to about 22.00%, about 22.00% to about 24.00%, about 24.00% to about 26.00%, about 26.00% to about 28.00%, about 28.00% to about 30.00%, about 30.00% to about 32.00%, about 32.00% to about 34.00%, about 34.00% to about 36.00%, about 36.00% to about 38.00%, about 38.00% to about 40.00%, about 40.00% to about 42.00%, about 42.00% to about 44.00%, about 44.00% to about 46.00%, about 46.00% to about 48.00%, about 48.00% to about 50.00%, about 50.00% to about 52.00%, about 52.00% to about 54.00%, about 54.00% to about 56.00%, about 56.00% to about 58.00%, about 58.00% to about 60.00%, about 60.00% to about 62.00%, about 62.00% to about 24.00%, about 64.00% to about 66.00%, about 66.00% to about 68.00%, about 68.00% to about 70.00%, about 70.00% to about 72.00%, about 72.00% to about 74.00%, about 74.00% to about 76.00%, about 76.00% to about 78.00%, about 78.00% to about 80.00%, about 80.00% to about 82.00%, about 82.00% to about 84.00%, about 84.00% to about 86.00%, about 86.00% to about 88.00%, about 88.00% to about 90.00%, about 90.00%, to about 92.00%, about 92.00% to about 94.00%, about 94.00% to about 96.00%, about 96.00% to about 98.00%, about 98.00% to about 100.00%), or overlapping ranges thereof.

[0059] The anhydrous phase can also include a phenyl trimethicone. In some embodiments, the phenyl trimethicone can be included as a skin conditioning agent that can impart a soft and silky feel upon the skin. In some embodiments, when phenyl trimethicone is combined with dimethicone or dimethicone crosspolymer, it can serve to set the size or duration of the spheres formed. In some embodiments, the phenyl trimethicone can be sold under the trade name Dow Corning 556 Cosmetic Grade Fluid. In some embodiments, the anhydrous phase can include a percentage of phenyl trimethicone that ranges from about 10.00%- 100.00%. In some embodiments, the percentage of phenyl trimethicone in the anhydrous phase can be about 10.00% to about 12.00%, about 12.00% to about 14.00%, about 14.00% to about 16.00%, about 16.00% to about 18.00%, about 18.00% to about 20.00%, about 20.00% to about 22.00%, about 22.00% to about 24.00%, about 24.00% to about 26.00%, about 26.00% to about 28.00%, about 28.00% to about 30.00%, about 30.00% to about 32.00%, about 32.00% to about 34.00%, about 34.00% to about 36.00%, about 36.00% to about 38.00%, about 38.00% to about 40.00%, about 40.00% to about 42.00%, about 42.00% to about 44.00%, about 44.00% to about 46.00%, about 46.00% to about 48.00%, about 48.00% to about 50.00%, about 50.00% to about 52.00%, about 52.00% to about 54.00%, about 54.00% to about 56.00%, about 56.00% to about 58.00%, about 58.00% to about 60.00%, about 60.00% to about 62.00%, about 62.00% to about 24.00%, about 64.00% to about 66.00%, about 66.00% to about 68.00%, about 68.00% to about 70.00%, about 70.00% to about 72.00%, about 72.00% to about 74.00%, about 74.00% to about 76.00%, about 76.00% to about 78.00%, about 78.00% to about 80.00%, about 80.00% to about 82.00%, about 82.00% to about 84.00%, about 84.00% to about 86.00%, about 86.00% to about 88.00%, about 88.00% to about 90.00%, about 90.00%, to about 92.00%, about 92.00% to about 94.00%, about 94.00% to about 96.00%, about 96.00% to about 98.00%, about 98.00%) to about 100.00%), or overlapping ranges thereof.

[0060] As discussed above, changing the ingredients of the composition and/or the ratio between the water phase and the anhydrous phase can create a composition that will have different effects on the spheres formed (for example, different sizes of spheres and/or differences in the duration in which they stay formed. For example, Figure 1 illustrates how, in some embodiments, changing certain ingredients - such as color - will not affect the size of the spheres formed in the composition. For example, the three formulations in Figure 1 produce a mixture having different colors but still with spheres ranging between 2 mm and 4 mm.

[0061] In some embodiments, the composition can be varied to produce mixtures with spheres that stay formed for different periods of time. For example, as shown in Figure 2, the compositions of each of the three vials have been varied to produce mixtures that form spheres ranging between 3 mm to 5 mm but that stay formed for 30 minutes (in the leftmost vial), 2 hours (in the rightmost vial), or experience no separation (center vial).

[0062] As will be shown below, by varying certain ingredients, the composition can be tailored to specific applications and uses. Below is provided a number of different example formulations for the sphere forming composition. Example 1

[0063] In some embodiments, the formulation of Example 1 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition is made up of 75% of Phase 1 and 25% of Phase 2.

[0064] In some examples, the composition of Example 1 can be formed by adding 40% of Phase 1 into a beaker and then slowly mixing Phase 2 into Phase 1 at a rate of 100- 200 rpms. The remaining 60% of Phase 1 can then be slowly mixed into the beaker. The composition can then be mixed for a few minutes, or until the two phases are uniform. It is observed that quickly mixing of the Phase 1 and Phase 2 will form smaller spheres.

[0065] The produced composition resembles a clear lava lamp and forms a semi- viscous serum. In some embodiments, the composition has a pH of 4.3. In some examples, the viscosity of the water phase is 7680 cps while the viscosity of the finished composition is 6000 cps. In some embodiments, the coloration of formulations A, B, and C is as follows: formulation A is gold champagne, formulation B is light amber, and formulation C is black.

[0066] In some embodiments, the spheres formed in Example 1 are between 1-2 mm in diameter. In some examples, the formulation of the composition of Example 1 produces spheres that do not separate into Phase 1 and Phase 2 for at least a period of 2 years.

[0067] A stability test was performed for the above disclosed formulation for Example 1. The formulation was observed over a period of three months and the following data was collected:

1 Week 1 Month 2 Months 3 Months

Temp.: Date: (01/19/2016) (02/12/2016) (03/12/2016) (04/12/2016)

Color: Conforms Conforms Conforms Conforms

Odor: Conforms Conforms Conforms Conforms

5°C Appearance: Conforms Conforms Conforms Conforms pH N/A N/A N/A N/A

Viscosity 6,120 6,720 6,400 7,000

Color: Conforms Conforms Conforms Conforms

Odor: Conforms Conforms Conforms Conforms

25°C

Appearance: Conforms Conforms Conforms Conforms (RT)

pH N/A N/A N/A N/A

Viscosity 7,080 7,840 7,440 7,840

Color: Conforms Conforms Conforms Conforms

Odor: Conforms Conforms Conforms Conforms

40°C

Appearance: Conforms Conforms Conforms Conforms w/ 75% RH

pH N/A N/A N/A N/A

Viscosity 7,480 8,080 7,260 8,080

Color: Conforms Conforms Conforms Conforms

Odor: Conforms Conforms Conforms Conforms

45°C Appearance: Conforms Conforms Conforms Conforms pH N/A N/A N/A N/A

Viscosity 7,680 7,800 7,320 8,080

[0068] As illustrated, the composition of Example 1 remains stable over a period of 3 months over a range of different temperatures.

Example 2

[0069] In some embodiments, the formulation of Example 2 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). The formulation of the composition of Example 2 can produce a 2 layer semi-viscous serum. The coloration of the composition of Example 2 can be a clear and/or hazy blue. In some embodiments, the composition of Example 2 has a water phase with a pH of 4.05.

[0070] In some embodiments, varying the percentage of various ingredients of the composition of Example 2 can results in different formulations that have spheres that form for different periods of time.

[0071] For example, formulation A forms a composition with a viscosity of 450 cps. Formulation A, when agitated, forms spheres that begin separating out into the two phases after approximately 3 minutes. Formulation A is observed to separate completely into the two phases after approximately 30 minutes. In some embodiments, formulation A is composed 65% of the Phase 1 water phase and 35% of the Phase 2 anhydrous phase. In some examples, the spheres formed in formulation A can range between 3-4 mm in size. [0072] In some examples, formulation B can form a composition with a viscosity of 1400 cps. Formulation B, when agitated, forms spheres that begin separating out into the two phases after approximately 30 minutes. Formulation B is observed to separate completely into the two phases after approximately 1-2 hours. In some embodiments, formulation B is composed 65% of the Phase 1 water phase and 35% of the Phase 2 anhydrous phase. In some examples, the spheres formed in formulation B can range between 3-4 mm in size.

[0073] In some examples, formulation C can form a composition with a viscosity of 1400 cps. Formulation C, when agitated, forms spheres that begin separating out into the two phases after approximately 2 hours. Formulation C is observed to separate completely into the two phases after approximately 8 hours. In some embodiments, formulation C is composed 65% of the Phase 1 water phase and 35% of the Phase 2 anhydrous phase. In some examples, the spheres formed in formulation C can range between 1-2 mm in size.

Example 3

[0074] In some embodiments, the formulation of Example 3 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the formulation of the composition of Example 3 is formed from a mixture of 75% of Phase 1 water phase and 25% of Phase 2 anhydrous phase. In some examples, the composition of Example 3 forms spheres of approximately 1-2 mm in diameter. As well, the spheres formed from the composition of Example 3 is observed to separate into the two phases between 6 months to 1 year after agitation of the composition.

[0075] In some examples, the composition of Example 3 forms small spheres in a viscous serum. In some embodiments, the composition can have a light pink color. In some examples, the Phase 1 water phase can have a pH of 4.10.

Example 4

[0076] In some embodiments, the formulation of Example 4 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the formulation of the composition of Example 4 produces a 2 layer semi-viscous liquid. The coloration of the composition of Example 4 is a clear blue color. In some embodiments, the composition of Example 4 has a water phase with a pH of 4.0 and a viscosity of 1400 cps. [0077] In some embodiments, varying the percentage of various ingredients of the composition of Example 4 as well as the ratio of the Phase 1 water phase and the Phase 2 anhydrous phase can produce formulations that form spheres for different periods of time.

[0078] For example, formulation D forms a composition that, when agitated, forms medium spheres that begin separating out into the two phases after approximately 24 hours. In some embodiments, formulation D is composed 65% of the Phase 1 water phase and 35% of the Phase 2 anhydrous phase.

[0079] In some examples, formulation E forms a composition that, when agitated, forms spheres that separate slightly after 24 hours. Formulation E is observed to form a top layer of spheres after a period of time between 24-48 hours after agitation. In some embodiments, formulation B is composed 70% of the Phase 1 water phase and 30% of the Phase 2 anhydrous phase.

[0080] In some examples formulation E forms a composition that, when agitated, forms medium spheres that begin separating out into the two phases after approximately 24 hours. In some embodiments, formulation E is composed 65% of the Phase 1 water phase and 35%) of the Phase 2 anhydrous phase.

Example 5

Phase 2 (Anhyt rous Phase)

A B

Material c

wt% wt% wt%

Botanisil GB-41 25.00 50.00 ___

DC 200, 100 CS 75.00 ___ ___

Armesil 12C — 50.00 55.00

Botanisil CTB-21 — — 45.00

[0081] In some embodiments, the formulation of Example 5 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 75% of Phase 1 and 25% of Phase 2.

[0082] The produced composition forms a 2 layer semi-viscous serum. In some embodiments, the Phase 1 water phase has a pH of 4.0. In some examples, the viscosity can range depending on the composition of the anhydrous phase. For example, the viscosity of formulations A, B, and C can be as follows: 1,400 cps, 2,000 cps, and 5,400 cps. In some examples, the composition can have a coloration that ranges between clear and blue.

Example 6

[0083] In some embodiments, the formulation of Example 6 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 65% of Phase 1 and 35% of Phase 2.

[0084] As discussed above, altering the amount of ingredient in the composition of Example 6 can alter the appearance and separation properties of the formulation. For example, Formulation D forms an opaque 2-layer thick serum when agitated. Formulation D can range in color from clear to slightly hazy. In some embodiments, formulation D can have a pH of 5.6. In some embodiments, formulation D has a viscosity of 4,200 cps.

[0085] In contrast, Formulation E forms a 2-layer semi-viscous serum. Formulation E can range in coloration from clear to a light blue color. In some examples Formulation E has a pH of 5.8. In some embodiments, formulation E has a viscosity of 1,500 cps. Formulation E is observed to not completely separate into two layers. Some quantity of the Phase 2 anhydrous phase is observed to remain intermixed with the Phase 1 water phase after the remainder of the formulation has predominantly separated.

Example 7

[0086] In some embodiments, the formulation of Example 7 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 65% of Phase 1 and 35% of Phase 2.

[0087] The produced composition forms a 2 layer semi-viscous serum. In some embodiments, the Phase 1 water phase has a pH of 4.0. In some examples, the composition can have a coloration that ranges between clear and light blue.

[0088] Formulations A, B, and C have compositions that contain different preservatives. Formulations A, B, and C include the following ingredients respectively: Geogard Ultra, Microkill COS, and Spectrastat. Geogard Ultra is useful as it is water soluble. Microkill COS is observed as producing a slightly hazy composition but is soluble when the two phases are agitated and mixed together.

Example 8

[0089] In some embodiments, the formulation of Example 8 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 65% of Phase 1 and 35% of Phase 2. [0090] The produced composition forms a 2 layer semi-viscous serum. In some embodiments, the Phase 1 water phase has a pH of 4.0. In some examples, the composition can have a coloration that ranges between clear and blue.

[0091] Example 8 replaces glycolic acid in the previous formulations with lactic acid. Lactic acid can serve the same function as glycolic acid and is observed to not affect the performance of the composition. The mixture formed by formulation Di is observed to separate more quickly than formulation D. In some embodiments, the formulations form large spheres when agitated.

Example 9

[0092] In some embodiments, the formulation of Example 9 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 70% of Phase 1 and 30% of Phase 2.

[0093] In some examples, the formulation of the composition of Example 9 produces a 2 layer semi-viscous liquid. The coloration of the composition of Example 9 can range from clear to a light blue color. In some embodiments, the composition of Example 4 has a water phase with a pH of 4.08.

[0094] In some embodiments, varying the percentage of various ingredients of the composition of Example 9 can produce formulations that form spheres for different periods of time when the composition is agitated.

[0095] For example, formulation A forms a composition that, when agitated, forms medium - large spheres that begin separating out into the two phases after approximately 2 hours. Formulation A is observed to form two separate layers in approximately 24 hours after agitation. Subsequently, formulation A is observed to form a top layer of spheres after approximately 4 days.

[0096] In some examples, formulation B forms a composition that, when agitated, forms small - medium spheres that begin separating approximately 2 hours after agitation.

[0097] In some examples formulation C forms a composition that, when agitated, forms medium - large spheres that begin separating out into the two phases after approximately 2 hours. Formulation C is observed to be stable at 4 weeks with a very thin layer of Phase 2 anhydrous phase.

Example 10

Phase 2 (Anhydrous Phase)

A B

Material c D E

wt% wt% wt% wt% wt%

Armesil 12C 70.00 70.00 85.00 50.00 50.00

Botanisil 21 30.00 30.00 15.00 ... ...

Botanisil 41 — — ... 50.00 50.00

[0098] In some embodiments, the formulation of Example 10 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 65% of Phase 1 and 35% of Phase 2.

[0099] In some examples, the formulation of the composition of Example 10 produces a 2 layer semi-viscous liquid. The coloration of the composition of Example 10 can range from clear to a blue color. In some embodiments, the composition of Example 10 has a water phase with a pH of 4.05.

[0100] In some embodiments, varying the percentage of various ingredients of the composition of Example 10 can produce formulations that form spheres for different periods of time when the composition is agitated.

[0101] For example, formulation A forms a composition that produces large sized spheres approximately 10-15 minutes after agitation. Formulation A is observed to begin separating out into the two phases approximately 30 minutes after agitation. Subsequently, formulation A completely separates 1 hour after agitation. In some embodiments, the viscosity of the Phase 1 water phase of formulation A is approximately 1400 cps.

[0102] In some examples, formulation B forms a composition that, when agitated, forms medium sized spheres within 5 minutes after agitation. Formulation B is observed to completely separate out into the two phases approximately 30 minutes after agitation. In some embodiments, the viscosity of the Phase 1 water phase of formulation B is approximately 520 cps.

[0103] In some examples formulation C forms a composition that, when agitated, forms medium sized spheres within 2 minutes after agitation. Formulation C is observed to begin separating out into the two phases approximately 15 minutes after agitation. Formulation C is observed to separate faster than formulation B. [0104] In some examples, formulation D forms a composition that, when agitated, forms medium sized spheres within 20 minutes after agitation. Formulation D is observed to begin separating 2 hours after agitation. After approximately 18-48 hours after agitation, the spheres are observed to form a top layer.

[0105] In some examples, formulation E forms a composition that forms medium sized spheres that begin to separate after approximately 3 minutes after agitation. Formulation E is observed as beginning to separate approximately 15 minutes after agitation. Formulation E completely separates out into two layers after approximately 30-40 minutes after agitation.

Example 11

[0106] In some embodiments, the formulation of Example 11 is a mixture of Phase 1 (water phase) and Phase 2 (anhydrous phase). In some embodiments, the composition has a ratio of 70% of Phase 1 and 30% of Phase 2. [0107] In some examples, the composition of Example 11 by mixing the Phase 1 water phase with the Phase 2 anhydrous Phase at slow mixing speeds, for example, at a rate of between 100-200 rpm. It is observed that higher sheer mixing speeds produce smaller spheres.

[0108] The produced composition forms a mixed bubble/sphere viscous serum. In some embodiments, the water phase has a pH of 4.1. In some examples, the viscosity of the water phase is 5000 cps while the viscosity of the anhydrous phase is 200 cps. In some embodiments, the coloration of formulations A, B, and C is as follows: formulation A is light amber, formulation B is gold champagne, and formulation C is black.

[0109] In some embodiments, the composition is stable after 3 months at a temperature of 50°C

[0110] Although the present disclosure includes certain embodiments, examples and applications, it will be understood by those skilled in the art that the present disclosure extends beyond the specifically disclosed embodiments to other alternative embodiments and/or uses and obvious modifications and equivalents thereof, including embodiments which do not provide all of the features and advantages set forth herein. Accordingly, the scope of the present disclosure is not intended to be limited by the specific disclosures of preferred embodiments herein.

[0111] When the singular forms "a," "an" and "the" or like terms are used herein, they will be understood to include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "an agent" includes two or more agents, and the like. The word "or" or like terms as used herein means any one member of a particular list and also includes any combination of members of that list.

[0112] Throughout the description and claims of this specification, the word

"comprise" and variations of the word, such as "comprising" and "comprises," means "including but not limited to," and is not intended to exclude, for example, other additives, components, integers or steps.

[0113] It is contemplated that various combinations or subcombinations of the specific features and aspects of the embodiments disclosed above may be made and still fall within one or more of the inventions. Further, the disclosure herein of any particular feature, aspect, method, property, characteristic, quality, attribute, element, or the like in connection with an embodiment can be used in all other embodiments set forth herein. Accordingly, it should be understood that various features and aspects of the disclosed embodiments can be combined with or substituted for one another in order to form varying modes of the disclosed inventions. Thus, it is intended that the scope of the present inventions herein disclosed should not be limited by the particular disclosed embodiments described above. Moreover, while the invention is susceptible to various modifications, and alternative forms, specific examples thereof have been shown in the drawings and are herein described in detail. It should be understood, however, that the invention is not to be limited to the particular forms or methods disclosed, but to the contrary, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the various embodiments described and the appended claims. Any methods disclosed herein need not be performed in the order recited. The methods disclosed herein include certain actions taken by a practitioner; however, they can also include any third-party instruction of those actions, either expressly or by implication. For example, actions such as "administering a two-phase composition" include "instructing the administration of a two-phase composition." The ranges disclosed herein also encompass any and all overlap, sub-ranges, and combinations thereof. Language such as "up to," "at least," "greater than," "less than," "between," and the like includes the number recited. Numbers preceded by a term such as "about" or "approximately" include the recited numbers. For example, "about 3 mm" includes "3 mm."