SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT

Title:

SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONISTS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT

Document Type and Number:

WIPO Patent Application WO/2014/129796

Kind Code:

A1

Abstract:

The present invention relates to novel compounds of Formula 1 as sphingosine-1-phosphate receptor agonists which can be effectively used for the treatment of autoimmune diseases, a method for preparing the same, and a pharmaceutical composition comprising the same as an active component. The compounds according to the present invention are effective on extensive autoimmune diseases and chronic inflammatory diseases including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulation disorders.

Inventors:

PAEK SEUNG YUP (KR)
LEE SUNG BAE (KR)
PARK DEOK SEONG (KR)
LEE WON HYUNG (KR)

Application Number:

PCT/KR2014/001336

Publication Date:

August 28, 2014

Filing Date:

February 19, 2014

Export Citation:

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Assignee:

LG LIFE SCIENCES LTD (KR)

International Classes:

C07D413/04; A61K31/4245; A61P37/00; C07D271/12

Domestic Patent References:

WO2008064320A2	2008-05-29
WO2011144338A1	2011-11-24
WO2008064320A2	2008-05-29
WO2011144338A1	2011-11-24

Foreign References:

US20110183953A1	2011-07-28
US20110152241A1	2011-06-23
US20080200535A1	2008-08-21
US20110207704A1	2011-08-25
US20110183953A1	2011-07-28
US20110152241A1	2011-06-23

Other References: