Title:
SPHINGOSINE ANALOGUES
Document Type and Number:
WIPO Patent Application WO/1998/040349
Kind Code:
A1
Abstract:
Novel sphingosine analogues useful as intermediates for the synthesis of novel lipid derivatives such as sphingolipid derivatives controlling the function of sphingolipid. The sphingosine analogues are represented by general formula (I), wherein Q?1� and Q?2� are each independently hydrogen, C�1?-C�4? alkyl, C�2?-C�5? acyl or an amino-protecting group and Q?3� is hydrogen or a hydroxyl-protecting group, or alternatively Q?2� and Q?3� are united to form isopropylidene and Q?1� is hydrogen or an amino-protecting group; Q?4� and Q?5� are each independently hydroxyl, C�2?-C�5? acyl, -O-Q?6� or hydrogen, or alternatively Q?4� and Q?5� may be united to form a covalent bond; Q?6� is a hydroxyl-protecting group; X?1� is -COOH, -CONH�2?, -CO-Q?7�, -CH�2?OH or -CH�2?O-Q?8�; Q?7� is a carboxyl-protecting group; and Q?8� is a hydroxyl-protecting group.
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Inventors:
TAKESAKO KAZUTOH (JP)
KUROME TORU (JP)
AWAZU NAOYUKI (JP)
KATO IKUNOSHIN (JP)
KUROME TORU (JP)
AWAZU NAOYUKI (JP)
KATO IKUNOSHIN (JP)
Application Number:
PCT/JP1998/001038
Publication Date:
September 17, 1998
Filing Date:
March 12, 1998
Export Citation:
Assignee:
TAKARA SHUZO CO (JP)
TAKESAKO KAZUTOH (JP)
KUROME TORU (JP)
AWAZU NAOYUKI (JP)
KATO IKUNOSHIN (JP)
TAKESAKO KAZUTOH (JP)
KUROME TORU (JP)
AWAZU NAOYUKI (JP)
KATO IKUNOSHIN (JP)
International Classes:
C07C215/10; C07C215/24; C07C229/22; C07C229/30; C07C237/08; C07C237/22; C07C251/08; C07C271/22; C07D263/06; C07D307/33; (IPC1-7): C07C215/10; C07C229/22; C07C271/22; C07C215/24; C07C229/30; C07D263/06
Foreign References:
| JPS62138497A | 1987-06-22 |
Other References:
TAMOWSKI ANDREJ et al., "Efficient Synthesis of Sphingosine-1-Phosphonate and Homo-Sphingosine-1-Phosphonate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 4 March 1997, Vol. 7, No. 5, pp. 573-576.
Attorney, Agent or Firm:
Yasutomi, Yasuo (14-22 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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