Title:
SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2019/158051
Kind Code:
A1
Abstract:
Disclosed in the present invention are an indoleamine-2,3-dioxygenase inhibitor and a preparation method therefor. The inhibitor of the present invention has a structure as represented by general formula (I), wherein the definitions of Ar, E, Y, X, V, D, W, B, ring A and ring B are as shown in the description and claims. Also disclosed in the present invention is a preparation method for the inhibitor. The compound of general formula (I) of the present invention can be used as an indoleamine-2,3-dioxygenase inhibitor for preparing a medicament for preventing and/or treating indoleamine-2,3-dioxygenase-mediated diseases.
Inventors:
WANG ZHAOYIN (CN)
GUO WEI (CN)
CHAI YONGSHUAI (CN)
GUO WEI (CN)
CHAI YONGSHUAI (CN)
Application Number:
PCT/CN2019/074855
Publication Date:
August 22, 2019
Filing Date:
February 12, 2019
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
C07D215/12; A61K31/47; A61K31/4709; A61P25/00; A61P25/22; A61P27/02; A61P31/18; A61P35/00; C07D215/18; C07D401/04; C07D405/04
Domestic Patent References:
| WO2017192840A1 | 2017-11-09 |
Foreign References:
| CN101312976A | 2008-11-26 | |||
| CN105732636A | 2016-07-06 | |||
| US5607915A | 1997-03-04 |
Other References:
"Cancer Principles and Practice of Oncology", 15 February 2001, LIPPINCOTT WILLIAMS & WILKINS
T. HIGUCHIV. STELLA: "A.C.S. 15 Symposium Series", vol. 14, article "Pro-drugs as Novel Delivery Systems"
"Bioreversible Carriers in Drug Design", 1987, APA AND PERGAMON
SAMBROOK ET AL.: "Conditions mentioned in the Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3753926A4
T. HIGUCHIV. STELLA: "A.C.S. 15 Symposium Series", vol. 14, article "Pro-drugs as Novel Delivery Systems"
"Bioreversible Carriers in Drug Design", 1987, APA AND PERGAMON
SAMBROOK ET AL.: "Conditions mentioned in the Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 3753926A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: METHOD FOR CONTROLLING TERMINAL TO USE WIRELESS NETWORK AND RELATED DEVICE
Next Patent: METHOD AND DEVICE FOR DETERMINING RESOURCES
Next Patent: METHOD AND DEVICE FOR DETERMINING RESOURCES