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Title:
SPIRO-RING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2008/090944
Kind Code:
A1
Abstract:
Disclosed is a compound represented by the formula (I) or a salt thereof, which has an inhibitory activity on acetyl-CoA carboxylase (ACC), is therefore useful for the prevention/treatment of obesity, diabetes, hypertension, hyperlipemia, heart failure, diabetic complications, metabolic syndrome, sarcopenia, cancer or the like, and has excellent pharmacological efficacy. (I) wherein R1 represents a hydrogen atom or a substituent; the ring P represents a 6-membered nitrogenated aromatic heterocyclic ring which may be substituted; the ring Q represents a 5- to 7-membered nitrogenated non-aromatic heterocyclic ring which may be furthersubstituted; and the ring R represents a 5- to 7-membered non-aromatic ring which may be further substituted and may be fused.

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Inventors:
FUKATSU KOHJI (JP)
KAMATA MAKOTO (JP)
YAMASHITA TOHRU (JP)
Application Number:
PCT/JP2008/050949
Publication Date:
July 31, 2008
Filing Date:
January 24, 2008
Export Citation:
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Assignee:
TAKEDA PHARMACEUTICAL (JP)
FUKATSU KOHJI (JP)
KAMATA MAKOTO (JP)
YAMASHITA TOHRU (JP)
International Classes:
C07D519/00; A61K31/4545; A61K31/695; A61P1/00; A61P1/04; A61P1/12; A61P1/14; A61P1/16; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P7/02; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/04; A61P13/10; A61P13/12; A61P15/00; A61P15/08; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P21/04; A61P25/02; A61P25/16; A61P25/22; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07F7/18; C07K5/02
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"Jikken Kagaku Kouza", vol. 20, pages: 304
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Midosuji Bldg. 1-1,Fushimimachi 4-chome,Chuo-ku, Osaka-shi, Osaka 44, JP)
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