Title:
SR- AND MG-DOPED AMORPHOUS APATITE MATERIAL AND CRYSTALLINE APATITE MATERIAL
Document Type and Number:
WIPO Patent Application WO/2017/080390
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedical materials, and provides a Sr- and/or Mg-doped amorphous apatite material and crystalline apatite material. Ca(NO3)2, Mg(NO3)2, Sr(NO3)2, (NH4)2HPO4, and ammonia are raw materials for fast preparation of an amorphous apatite material doped with Sr or Mg in different concentrations, and the amorphous apatite material is then thermally treated to be converted into a nanosized calcium-deficient hydroxyapatite or nanosized tricalcium phosphate material doped with Sr or Mg in different concentrations. Compared with the conventional crystalline hydroxyapatite material, the amorphous material has higher solubility. With Sr or Mg doped, Sr facilitates formation of new bone, reduces bone resorption, regulates calcium metabolism, and lowers the osteoclastic activity; Mg can affect the early stage of bone growth, and regulate and control growth and reformation of bone. The synthesized amorphous apatite and a crystalized product thereof have a significant role in the fields of bone repair and bone grafting.
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Inventors:
ZHANG XING (CN)
CAO LEI (CN)
YANG RUI (CN)
CAO LEI (CN)
YANG RUI (CN)
Application Number:
PCT/CN2016/104286
Publication Date:
May 18, 2017
Filing Date:
November 02, 2016
Export Citation:
Assignee:
INST OF METAL RES CHINESE ACAD OF (CN)
International Classes:
C01B25/32; A61K6/04; A61K6/838; A61L27/04; A61L27/12; A61L27/54; A61L27/58; B82Y40/00
Foreign References:
| CN101322858A | 2008-12-17 | |||
| CN105439110A | 2016-03-30 |
Other References:
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HE, LIZHI ET AL.: "Microwave Synthesis and Characterization of Nano-sized Calcium Deficient Hydroxyapatite with Different Ca/P Ratio", GUANGZHOU CHEMICAL INDUSTRY, vol. 37, no. 4, 31 December 2009 (2009-12-31), pages 74 - 76
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YAN, YANG.: "Phase Transformation Dynamic of Amorphous Calcium Phosphate", SCIENCE -ENGINEERING (A), CHINA MASTER'S THESES FULL-TEXT DATABASE, vol. 1, no. 3, 15 March 2013 (2013-03-15)
HE, LIZHI ET AL.: "Microwave Synthesis and Characterization of Nano-sized Calcium Deficient Hydroxyapatite with Different Ca/P Ratio", GUANGZHOU CHEMICAL INDUSTRY, vol. 37, no. 4, 31 December 2009 (2009-12-31), pages 74 - 76
LIU, RONGFANG ET AL.: "Study on Kinetics of Hydrothermal Synthesis of Hydroxyapatite Powders", CHINESE JOURNAL OF INORGANIC CHEMISTRY, vol. 19, no. 10, 31 October 2003 (2003-10-31), pages 1079 - 1084
XI, XIAOLI ET AL.: "Study on Mechanism of Precursor Powder Prepared by Freeze-drying", JOURNAL OF BEIJING UNIVERSITY OF TECHNOLOGY, vol. 33, no. 11, 30 November 2007 (2007-11-30), pages 1207 - 1211
Attorney, Agent or Firm:
SHENYANG PATENT & TRADEMARK AGENCY ACADEMIA (CN)
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