Title:
STABILIZATION OF POLYSULFIDE
Document Type and Number:
WIPO Patent Application WO/2021/172523
Kind Code:
A1
Abstract:
The present invention is a novel tyrosine derivative for inhibiting the hydrolysis of a polysulfide. A novel tyrosine derivative represented by the following chemical formula. One of a to c represents "OH" and each of the remaining variables represents "H"; d represents CnH2nα; α represents "H" or a "halogen atom", wherein the halogen atom is preferably "I"; n represents an integer of 1 to 5; e represents (NH)x(CO)yCzH2zβ; x represents 1 or 0; y represents 1 or 0; z represents an integer of 1 to 5; and β represents "H" or a "halogen atom".
Inventors:
IHARA HIDESHI (JP)
KASAMATSU SHINGO (JP)
KASAMATSU SHINGO (JP)
Application Number:
PCT/JP2021/007397
Publication Date:
September 02, 2021
Filing Date:
February 26, 2021
Export Citation:
Assignee:
UNIV OSAKA PUBLIC CORP (JP)
BIO XCELERATOR INC (JP)
BIO XCELERATOR INC (JP)
International Classes:
C07C233/47; C07C237/22; C07C323/52; G01N31/00
Other References:
GUERITTE, FRANCOISE ET AL.: "Composés antitumoraux du groupe de la vinblastine : dérivés de la nor-5' anhydrovinblastine - [Antitumor compounds in vinblastine group: nor-5'-anhydrovinblastine derivatives]", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - CHIMICA THERAPEUTICA, vol. 18, no. 5, 30 November 1982 (1982-11-30), FR, pages 419 - 424, XP009530589
ADBERHALDEN, EMIL ET AL.: "Further Contribution to Knowledge of 3,5-Diiode-1- tyrosine", BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, vol. 41, 1908, pages 2852 - 2857, XP009530738
"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics", NATURE COMMUNICATIONS, vol. 8, 27 October 2017 (2017-10-27), pages 1177
IDA T. ET AL., PNAS, 2014
MUSTAFA A., SCIENCE, 2009
GAO XH. ET AL., ELIFE, 2016
YANG R. ET AL., IMMUNITY, 2015
DOKA E. ET AL., SCI. ADV., 2016
JUNG M. ET AL., BBRC, 2016
"Science Direct", REDOX BIOLOGY, vol. 21, 2019, pages 101096
See also references of EP 4112597A4
ADBERHALDEN, EMIL ET AL.: "Further Contribution to Knowledge of 3,5-Diiode-1- tyrosine", BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT, vol. 41, 1908, pages 2852 - 2857, XP009530738
"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics", NATURE COMMUNICATIONS, vol. 8, 27 October 2017 (2017-10-27), pages 1177
IDA T. ET AL., PNAS, 2014
MUSTAFA A., SCIENCE, 2009
GAO XH. ET AL., ELIFE, 2016
YANG R. ET AL., IMMUNITY, 2015
DOKA E. ET AL., SCI. ADV., 2016
JUNG M. ET AL., BBRC, 2016
"Science Direct", REDOX BIOLOGY, vol. 21, 2019, pages 101096
See also references of EP 4112597A4
Attorney, Agent or Firm:
OHGA, Shinji et al. (JP)
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