Title:
STABILIZED PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2008/023807
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a stabilized liquid pharmaceutical composition comprising 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium or a pharmaceutically acceptable salt thereof, in which the degradation of the compound over time can be prevented when the pharmaceutical composition is applied to clinical practice, and also provide a method for stabilizing the liquid pharmaceutical composition. [MEANS FOR SOLVING PROBLEMS] A stabilized liquid pharmaceutical composition comprising 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium or a pharmaceutically acceptable salt thereof, characterized by further containing at least one member selected from the group consisting of carbazochrome sodium sulfonate and a derivative thereof, vitamin C, butyl hydroxyanisole, vitamin E, vitamin P, gallic acid, propyl gallate, alpha-thioglycerin and cysteine hydrochloride; a lyophilized product of the pharmaceutical composition; and a method for stabilizing the pharmaceutical composition.
Inventors:
MURAI, Makoto (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
村井 真 (〒11 東京都中央区日本橋本町二丁目３番１１号 アステラス製薬株式会社内 Tokyo, 1038411, JP)
YONEMOCHI, Yuichi (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
米持 雄一 (〒11 東京都中央区日本橋本町二丁目３番１１号 アステラス製薬株式会社内 Tokyo, 1038411, JP)
村井 真 (〒11 東京都中央区日本橋本町二丁目３番１１号 アステラス製薬株式会社内 Tokyo, 1038411, JP)
YONEMOCHI, Yuichi (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
米持 雄一 (〒11 東京都中央区日本橋本町二丁目３番１１号 アステラス製薬株式会社内 Tokyo, 1038411, JP)
Application Number:
JP2007/066495
Publication Date:
February 28, 2008
Filing Date:
August 24, 2007
Export Citation:
Assignee:
ASTELLAS PHARMA INC. (3-11, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo, 11, 1038411, JP)
アステラス製薬株式会社 (〒11 東京都中央区日本橋本町二丁目３番１１号 Tokyo, 1038411, JP)
MURAI, Makoto (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
村井 真 (〒11 東京都中央区日本橋本町二丁目３番１１号 アステラス製薬株式会社内 Tokyo, 1038411, JP)
YONEMOCHI, Yuichi (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
アステラス製薬株式会社 (〒11 東京都中央区日本橋本町二丁目３番１１号 Tokyo, 1038411, JP)
MURAI, Makoto (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
村井 真 (〒11 東京都中央区日本橋本町二丁目３番１１号 アステラス製薬株式会社内 Tokyo, 1038411, JP)
YONEMOCHI, Yuichi (3-11 Nihonbashi-Honcho2-chom, Chuo-ku Tokyo 11, 1038411, JP)
International Classes:
A61K31/497; A61K9/08; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/20; A61K47/22; A61K31/4965; A61K9/08; A61K47/10; A61K47/12; A61K47/14; A61K47/16; A61K47/20; A61K47/22
Attorney, Agent or Firm:
MORITA, Hiroshi et al. (3-11 Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, 1038411, JP)
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