Title:
STABLE 6-METHOXY-2',3'-DIDEOXYGUANOSINE, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
WIPO Patent Application WO/2009/089702
Kind Code:
A1
Abstract:
A stable 6-methoxy-2', 3'-dideoxyguanosine comprises 6-30% water content. It is prepared by absorbing water in 6-methoxy-2', 3'-dideoxyguanosine with less than 6% water content at low temperature and certain humidity, or drying 6-methoxy-2', 3'-dideoxyguanosine with more than 30% water content. The stable 6-methoxy-2', 3'-dideoxyguanosine can be used to prepare medicament composition, and be used to manufacture pharmaceutical for fighting hepatitis B virus or HIV.
Inventors:
LI ZHAN (CN)
HUANG HAIYAN (CN)
LIU CAILIAN (CN)
JIANG LIXUN (CN)
HUANG HAIYAN (CN)
LIU CAILIAN (CN)
JIANG LIXUN (CN)
Application Number:
PCT/CN2008/072646
Publication Date:
July 23, 2009
Filing Date:
October 10, 2008
Export Citation:
Assignee:
NANJING CHANGAO PHARMACEUTICAL (CN)
LI ZHAN (CN)
HUANG HAIYAN (CN)
LIU CAILIAN (CN)
JIANG LIXUN (CN)
LI ZHAN (CN)
HUANG HAIYAN (CN)
LIU CAILIAN (CN)
JIANG LIXUN (CN)
International Classes:
C07H19/16; A61K31/7115; A61P1/16; A61P31/12; A61P31/18
Domestic Patent References:
| WO1990006312A1 | 1990-06-14 |
Foreign References:
| CN101220071A | 2008-07-16 | |||
| CN101147728A | 2008-03-26 | |||
| US5185437A | 1993-02-09 | |||
| CN1493301A | 2004-05-05 | |||
| CN1415622A | 2003-05-07 | |||
| CN1493301A | 2004-05-05 | |||
| CN1415622A | 2003-05-07 |
Other References:
ROBINS M.J. ET AL.: "Nucleic Acid-Related Compounds. 88. Efficient Conversions of Ribonucleosides into Their 2',3'-Anhydro, 2'(and 3')-Deoxy, 2',3'-Didehydro-2', 3'-dideoxy, and 2', 3'-Dideoxynucleoside Analogs.", J. ORG. CHEM., vol. 60, no. 24, 1995, pages 7902 - 7908, XP002277613
See also references of EP 2241571A4
ROBINS M. J., J. ORG. CHEM., vol. 60, no. 24, 1995, pages 7902 - 7908
See also references of EP 2241571A4
ROBINS M. J., J. ORG. CHEM., vol. 60, no. 24, 1995, pages 7902 - 7908
Attorney, Agent or Firm:
YIN INT'L IP FIRM (13 Huayuan Road Haidian District, Beijing 8, CN)
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