STABLE AQUEOUS PHARMACEUTICAL COMPOSITION OR FREEZE-DRIED PHARMACEUTICAL COMPOSITION

Title:

STABLE AQUEOUS PHARMACEUTICAL COMPOSITION OR FREEZE-DRIED PHARMACEUTICAL COMPOSITION

Document Type and Number:

WIPO Patent Application WO/2022/202947

Kind Code:

A1

Abstract:

Disclosed is a stable aqueous pharmaceutical composition or freeze-dried pharmaceutical composition that comprises a protein as an active ingredient. This pharmaceutical composition comprises a protein having a physiological activity and two kinds of nonionic surfactants and includes, for example, a composition in which the nonionic surfactants are Polysorbate 80 and polyoxyethylene (160) polyoxypropylene (30) glycol and which further contains, as optional ingredients, sodium chloride as a neutral salt, sucrose as a disaccharide and a citrate buffer as a buffer.

Inventors:

YASUKAWA HIDEHITO (JP)
MURASE HIROAKI (JP)
YAMAGUCHI YUKA (JP)
OKABE SHINJI (JP)

Application Number:

PCT/JP2022/013755

Publication Date:

September 29, 2022

Filing Date:

March 23, 2022

Export Citation:

Click for automatic bibliography generation Help

Assignee:

JAPAN CHEM RES (JP)

International Classes:

A61K38/43; A61J1/05; A61K9/08; A61K9/19; A61K38/47; A61K39/395; A61K45/00; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/26; A61K47/34; A61K47/65; A61K47/68; A61P3/00; A61P43/00; C07K16/28; C07K16/46; C12N9/24; C12N15/13; C12N15/56; C12N15/62

Domestic Patent References:

WO2018124277A1

2018-07-05

Foreign References:

JPH10513433A	1998-12-22
JP2020506955A	2020-03-05
JP2010525034A	2010-07-22
JP2019048800A	2019-03-28
JP6279466B2	2018-02-14

Other References:

ALTSCHUL SF, J MOL. BIOL., vol. 215, 1990, pages 403 - 10
PEARSONLIPMAN, PROC. NATL. ACAD. SCI. USA., vol. 85, 1988, pages 2444
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482 - 9
MIYAHARA M., J. BIOL. CHEM., vol. 275, 2000, pages 613 - 618