Title:
STABLE CANNABINOID COMPOSITIONS AND METHODS FOR MAKING AND STORING THEM
Document Type and Number:
WIPO Patent Application WO/2012/071389
Kind Code:
A3
Abstract:
A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically- acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.
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Inventors:
ROSSI RONALD (US)
SILVERBERG LEE JONATHAN (US)
HOGAN ROBERT (US)
SHAH RAMESH M (US)
SILVERBERG LEE JONATHAN (US)
HOGAN ROBERT (US)
SHAH RAMESH M (US)
Application Number:
PCT/US2011/061803
Publication Date:
August 09, 2012
Filing Date:
November 22, 2011
Export Citation:
Assignee:
JOHNSON MATTHEY PLC (GB)
ROSSI RONALD (US)
SILVERBERG LEE JONATHAN (US)
HOGAN ROBERT (US)
SHAH RAMESH M (US)
ROSSI RONALD (US)
SILVERBERG LEE JONATHAN (US)
HOGAN ROBERT (US)
SHAH RAMESH M (US)
International Classes:
A61K9/48; A61K31/352; A61K47/10; A61K47/12; A61K47/44
Domestic Patent References:
| WO2009020666A1 | 2009-02-12 |
Foreign References:
| US8039509B2 | 2011-10-18 | |||
| US20080139644A1 | 2008-06-12 |
Other References:
SOLVAY PHARMACEUTICALS INC.: "NDA 18-651/S-021; MARINOL (Dronabinol) capsules", September 2004 (2004-09-01), XP002671413, Retrieved from the Internet [retrieved on 20120313]
CHRISTIAN LINDHOLST: "Long term stability of cannabis resin and cannabis extracts", AUSTRALIAN JOURNAL OF FORENSIC SCIENCES, vol. 42, no. 3, 5 July 2010 (2010-07-05), pages 181 - 190, XP055029938, ISSN: 0045-0618, DOI: 10.1080/00450610903258144
CHRISTIAN LINDHOLST: "Long term stability of cannabis resin and cannabis extracts", AUSTRALIAN JOURNAL OF FORENSIC SCIENCES, vol. 42, no. 3, 5 July 2010 (2010-07-05), pages 181 - 190, XP055029938, ISSN: 0045-0618, DOI: 10.1080/00450610903258144
Attorney, Agent or Firm:
LEWIS, Christopher, R. (P.O. Box 980Valley Forge, PA, US)
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