Title:
STABLE LIQUID PHARMACEUTICAL COMPOSITION CONTAINING PIROXICAM OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND HYALURONIC ACID OR ITS PHARMACEUTICALLY ACCEPTABLE SALT AND THE MANUFACTURING METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/133647
Kind Code:
A1
Abstract:
The present invention relates to a novel liquid composition comprised of piroxicam or its pharmaceutically acceptable salt (a non-steroid anti-inflammatory drug) and hyaluronic acid or its pharmaceutically acceptable salt (used for treatment of degenerative arthritis). Specifically, the invention provides a highly physicochemically stable liquid injection, comprising piroxicam and hyaluronic acid as active ingredients and β-cyclodextrin or its derivative and polyethylene glycol as additives to enhance its physicochemical stability, and the preparation method thereof. Therefore, the novel composition and the formulation method thereof provided by the present invention may be used to produce a liquid injection composition of piroxicam and hyaluronic acid.
Inventors:
KIM SOON-HOE (KR)
SON MI-WON (KR)
JANG SUN-WOO (KR)
KANG MYUNG-JOO (KR)
MA KYUNG-WAN (KR)
SON MI-WON (KR)
JANG SUN-WOO (KR)
KANG MYUNG-JOO (KR)
MA KYUNG-WAN (KR)
Application Number:
PCT/KR2013/001856
Publication Date:
September 12, 2013
Filing Date:
March 07, 2013
Export Citation:
Assignee:
DONG A ST CO LTD (KR)
International Classes:
A61K31/728; A61K31/54; A61P25/00; A61P29/00
Domestic Patent References:
| WO1997024111A2 | 1997-07-10 |
Foreign References:
| US4603123A | 1986-07-29 | |||
| EP0795329B1 | 2001-01-31 |
Other References:
MING GUAN PIAO ET AL.: "Enhanced Oral Bioavailability of Piroxicam in Rats by Hyaluronate Microspheres", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 33, no. 4, 2007, pages 485 - 491, XP055161745
See also references of EP 2822561A4
See also references of EP 2822561A4
Attorney, Agent or Firm:
ROH, Jae-Chull (4F. 30 ,Teheran-ro 25-gil,Gangnam-gu, Seoul 135-909, KR)
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Claims: