Title:
STABLE ORAL COMPOSITIONS COMPRISING CASEIN PHOSPHOPEPTIDE COMPLEXES AND FLUORIDE
Document Type and Number:
WIPO Patent Application WO2003059303
Kind Code:
A3
Abstract:
The present invention relates to oral care compositions, especially toothpastes, comprising: a safe and effective amount of phosphopeptide-amorphous calcium phosphate complex ("PP-ACP"); a safe and effective amount of a fluoride ion source; a safe and effective amount of a phosphate buffer; a pharmaceutically-acceptable topical, oral carrier; wherein the pH of the final composition is greater than 8 to about 12 and the composition has improved fluoride stability. This invention further relates to a method of maintaining the fluoride levels in an oral care composition comprising a safe and effective amount of PP-ACP, a safe and effective amount of a fluoride ion source, and a pharmaceutically-acceptable topical, oral carrier, by adjusting the pH of the composition to greater than 8 to about 12 and by adding, to the composition, a safe and effective amount of a phosphate buffer.
Inventors:
DIXON CLOYD JR
KAMINSKI MICHAEL ANTHONY
HUGHES TIMOTHY JOHN
KAMINSKI MICHAEL ANTHONY
HUGHES TIMOTHY JOHN
Application Number:
PCT/US2002/039599
Publication Date:
December 04, 2003
Filing Date:
December 11, 2002
Export Citation:
Assignee:
PROCTER & GAMBLE (US)
International Classes:
A61K8/21; A61K8/24; A61K8/64; A61Q11/00; (IPC1-7): A61K7/16
Domestic Patent References:
| WO1998040406A1 | 1998-09-17 |
Foreign References:
| US4314990A | 1982-02-09 | |||
| US5834427A | 1998-11-10 |
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