Title:
STABLE PHARMACEUTICAL COMPOSITION FOR OPTIMIZED DELIVERY OF AN HIV ATTACHMENT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2010/028108
Kind Code:
A3
Abstract:
A pharmaceutical composition contains the compound 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, and hydroxypropyl methyl cellulose (HPMC) having a viscosity of at least about 100 cP, wherein the composition does not contain any enzyme inhibitors.
Inventors:
BROWN JONATHAN R (GB)
TOALE HELEN (GB)
DENNIS ANDREW B (GB)
TIMMINS PETER (GB)
TOALE HELEN (GB)
DENNIS ANDREW B (GB)
TIMMINS PETER (GB)
Application Number:
PCT/US2009/055820
Publication Date:
September 02, 2010
Filing Date:
September 03, 2009
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
BROWN JONATHAN R (GB)
TOALE HELEN (GB)
DENNIS ANDREW B (GB)
TIMMINS PETER (GB)
BROWN JONATHAN R (GB)
TOALE HELEN (GB)
DENNIS ANDREW B (GB)
TIMMINS PETER (GB)
International Classes:
A61K31/00; A61K9/20
Domestic Patent References:
| WO2007070589A2 | 2007-06-21 |
Foreign References:
| US20050209246A1 | 2005-09-22 | |||
| US7354924B2 | 2008-04-08 | |||
| US20060293304A1 | 2006-12-28 |
Other References:
WILLIAMS ROBERT O III ET AL: "INVESTIGATION OF EXCIPIENT TYPE AND LEVEL ON DRUG RELEASE FROM CONTROLLED RELEASE TABLETS CONTAINING HPMC", PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, NEW YORK, NY, US LNKD- DOI:10.1081/PDT-120003486, vol. 7, no. 2, 1 January 2002 (2002-01-01), pages 181 - 193, XP008074890, ISSN: 1083-7450
Attorney, Agent or Firm:
LEVIS, John, F. et al. (P.O. Box 4000Princeton, New Jersey, US)
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