Title:
A STABLE PHARMACEUTICAL FORMULATION COMPRISING TELMISARTAN AND HYDROCHLOROTHIAZIDE
Document Type and Number:
WIPO Patent Application WO/2011/147026
Kind Code:
A3
Abstract:
The present invention is directed to a stable pharmaceutical formulation comprising telmisartan, or a pharmaceutically acceptable salt thereof/ and a diuretic dispersed in a matrix. The matrix comprises at least one disinte grant in an amount ranging from 0.5 % to 20% by weight; a dissolution enhancing agent present in a molar ratio of dissolution enhancing agent to telmisartan of from 1:1 to 10:1; a water-insoluble diluent in an amount ranging from 15%-75% by weight and at least one other pharmaceutically acceptable excipient /or adjuvant in an amount ranging from 0 - 25% by weight,
Inventors:
TALWAR NARESH (CA)
SEBASTIAN DEAN (CA)
PHILIP MATHEW (CA)
SEBASTIAN DEAN (CA)
PHILIP MATHEW (CA)
Application Number:
PCT/CA2011/000621
Publication Date:
January 26, 2012
Filing Date:
May 27, 2011
Export Citation:
Assignee:
PHARMASCIENCE INC (CA)
TALWAR NARESH (CA)
SEBASTIAN DEAN (CA)
PHILIP MATHEW (CA)
TALWAR NARESH (CA)
SEBASTIAN DEAN (CA)
PHILIP MATHEW (CA)
International Classes:
A61K31/4184; A61K9/20; A61K31/549; A61P9/12; A61J3/00
Domestic Patent References:
| WO2011025467A1 | 2011-03-03 | |||
| WO2004028505A1 | 2004-04-08 |
Foreign References:
| CA2524091A1 | 2004-11-11 | |||
| CA2644179A1 | 2009-05-21 |
Attorney, Agent or Firm:
SHEAHAN, Ryan (Suite 160050 O'Connor Stree, Ottawa Ontario K1P 6L2, CA)
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