Title:
STABLE PHARMACEUTICAL FORMULATIONS OF ZONISAMIDE AND METHODS FOR THEIR MANUFACTURE
Document Type and Number:
WIPO Patent Application WO2006078948
Kind Code:
B1
Abstract:
One of the embodiments of the present invention is directed toward a process for preparing a stable zonisamide pharmaceutical composition, comprising subjecting zonisamide to wet granulation with a granulation liquid to form a granulated mixture as the stable zonisamide pharmaceutical composition, wherein the granulation liquid is selected from purified water, alcohol and mixtures thereof. The stable zonisamide pharmaceutical composition can be used to fill capsule shells to prepare stable zonisamide capsules. Another embodiment of the invention concerns a for preparing a stable zonisamide pharmaceutical capsule, comprising (i) forming an intimate mixture with zonisamide powder and an effective amount of at least one pharmaceutically acceptable excipient by compressing, co-milling, co-micronization and/or co-compaction of the components, or subjecting the components to a similarly intensive process; and (ii) filling capsule shells with the intimate mixture to obtain the stable zonisamide pharmaceutical capsule.
Inventors:
HRAKOVSKY JULIA (IL)
TENENGAUZER RUTH (IL)
TENENGAUZER RUTH (IL)
Application Number:
PCT/US2006/002103
Publication Date:
March 01, 2007
Filing Date:
January 20, 2006
Export Citation:
Assignee:
TEVA PHARMA (US)
TEVA PHARMA (US)
HRAKOVSKY JULIA (IL)
TENENGAUZER RUTH (IL)
TEVA PHARMA (US)
HRAKOVSKY JULIA (IL)
TENENGAUZER RUTH (IL)
International Classes:
A61K9/16; A61K31/423; A61K9/14
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