Title:
STANDARD LIBRARY OF LOW-MOLECULAR-WEIGHT HEPARIN, NADROPARIN CALCIUM, AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/000336
Kind Code:
A1
Abstract:
The present invention provides a method for preparing a standard library of a low-molecular-weight heparin, nadroparin calcium, and a product thereof. The method uses crude heparin sodium as a raw material and is based on enzymatic hydrolysis and a modified nitrite degradation method. After the steps of enzymatic hydrolysis, oxidative decolorization, purification by ultrafiltration, purification by ethanol precipitation, degradation, reduction, ultraviolet radiation, oxidation, calcium replacement, nanofiltration, refining by ultrafiltration, freeze drying, etc., a standard library of a low-molecular-weight heparin, nadroparin calcium, with a particular average molecular weight can be prepared.
Inventors:
ZHOU XIA (CN)
LEI XIAOGANG (CN)
QIAO DEQIANG (CN)
GUO WEI (CN)
LIN YONG (CN)
GUO ENZHONG (CN)
LEI XIAOGANG (CN)
QIAO DEQIANG (CN)
GUO WEI (CN)
LIN YONG (CN)
GUO ENZHONG (CN)
Application Number:
PCT/CN2017/090904
Publication Date:
January 03, 2019
Filing Date:
June 29, 2017
Export Citation:
Assignee:
CISEN PHARMACEUTICAL CO LTD (CN)
SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTD (CN)
SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C08B37/10; C12Q1/00
Foreign References:
| CN103275246A | 2013-09-04 | |||
| CN104163878A | 2014-11-26 | |||
| CN104072639A | 2014-10-01 |
Attorney, Agent or Firm:
CHOFN INTELLECTUAL PROPERTY (CN)
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