Title:
STAPHYLOCOCCUS AUREUS EFB PROTEIN AND C3 BINDING REGION WHICH INHIBIT COMPLEMENT ACTIVATION
Document Type and Number:
WIPO Patent Application WO2004094600
Kind Code:
A3
Abstract:
The Efb protein from Staphylococcus aureus has now been shown to have the ability to bind to the C3 protein which is a crucial component in the activation of complement, and a specific C3 binding region has been located at the C-terminal end of the Efb protein. Isolated proteins and protein fragments containing the Efb protein C3 binding region are thus provided which have complement inhibiting activity, and these proteins and fragments are particularly useful in therapeutic methods wherein the inhibition of complement is desirable, such as in the treatment of hemolytic anemia, the prevention of graft or implant rejection, and to alleviate complement activation that is associated with kidney dialysis methods such as hemodialysis.
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Inventors:
BROWN ERIC (US)
LEE LAWRENCE (US)
HOOK MAGNUS (US)
LEE LAWRENCE (US)
HOOK MAGNUS (US)
Application Number:
PCT/US2004/011949
Publication Date:
April 07, 2005
Filing Date:
April 16, 2004
Export Citation:
Assignee:
TEXAS A & M UNIV SYS (US)
BROWN ERIC (US)
LEE LAWRENCE (US)
HOEOEK MAGNUS (US)
BROWN ERIC (US)
LEE LAWRENCE (US)
HOEOEK MAGNUS (US)
International Classes:
A61K39/02; A61K39/085; A61K39/38; C07K1/00; C07K2/00; C07K14/31; G01N33/569; A61K39/00; C12N; (IPC1-7): C07K1/00; C07K2/00; A61K39/02; A61K39/085; A61K39/38; A61K39/00
Foreign References:
| US20020173462A1 | 2002-11-21 | |||
| US6299879B1 | 2001-10-09 |
Other References:
BODEN, M.K. ET AL.: "Cloning and characterization of a genee for a 19 kDa fibrinogen-binding protein from Staphylococcus aureus", MOL. MICROBIOL., vol. 124, 1994, pages 599 - 606, XP008095146
BODEN, M.K. ET AL.: "Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman", MICROB. PATHOGENESIS, vol. 12, 1992, pages 289 - 298, XP008095143
BODEN, K.B. ET AL.: "Fibrinogen-binding protein/clumping factor from Staphylococcus aureus", INFECT. IMMUN., vol. 57, no. 8, August 1989 (1989-08-01), pages 2358 - 2363, XP008095147
BODEN, M.K. ET AL.: "Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman", MICROB. PATHOGENESIS, vol. 12, 1992, pages 289 - 298, XP008095143
BODEN, K.B. ET AL.: "Fibrinogen-binding protein/clumping factor from Staphylococcus aureus", INFECT. IMMUN., vol. 57, no. 8, August 1989 (1989-08-01), pages 2358 - 2363, XP008095147
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