Title:
STAPLED PEPTIDES AND METHOD OF SYNTHESIS
Document Type and Number:
WIPO Patent Application WO/2010/033617
Kind Code:
A3
Abstract:
A method for preparing stapled peptides. The stapled peptides, including helical stapled peptides, are prepared according to a photochemically-based method, a [3+2] cycloaddition reaction. The helical stapled peptides exhibit increased helicity, thermal stability and cell permeability.
Inventors:
LIN QING (US)
MADDEN MICHAEL (US)
RIVERA VERA CLAUDIA IVETTE (US)
MADDEN MICHAEL (US)
RIVERA VERA CLAUDIA IVETTE (US)
Application Number:
PCT/US2009/057189
Publication Date:
September 23, 2010
Filing Date:
September 16, 2009
Export Citation:
Assignee:
UNIV NEW YORK STATE RES FOUND (US)
LIN QING (US)
MADDEN MICHAEL (US)
RIVERA VERA CLAUDIA IVETTE (US)
LIN QING (US)
MADDEN MICHAEL (US)
RIVERA VERA CLAUDIA IVETTE (US)
International Classes:
B01J19/12; A61K38/00; C07D213/61
Foreign References:
| US6783763B1 | 2004-08-31 | |||
| US20070248567A1 | 2007-10-25 |
Other References:
BERNAL ET AL.: "Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide.", J. AM. CHEM. SOC., vol. 129, 2007, pages 2456 - 2457, XP009107955
VOITEKHOVICH ET AL.: "THERMAL RECYCLIZATION OF 5-R-2-ISOPROPENYLTETRAZOLES INTO 5-R-3-METHYLPYRAZOLES.", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 38, no. 11, 2002, pages 1422, XP008145672
DATABASE PUBCHEM [online] 2005, XP008145671, Database accession no. 402857
VOITEKHOVICH ET AL.: "THERMAL RECYCLIZATION OF 5-R-2-ISOPROPENYLTETRAZOLES INTO 5-R-3-METHYLPYRAZOLES.", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 38, no. 11, 2002, pages 1422, XP008145672
DATABASE PUBCHEM [online] 2005, XP008145671, Database accession no. 402857
Attorney, Agent or Firm:
ROMAN, Paul, J. et al. (The Guaranty Building 140 Pearl Street, Suite 10, Buffalo NY, US)
Download PDF: