Title:
STARCH NANOPARTICLES FOR DRUG DELIVERY SYSTEMS
Document Type and Number:
WIPO Patent Application WO/2010/084088
Kind Code:
A3
Abstract:
Polymeric nanoparticles comprising hydrophobic and/or amphiphilic starch derivatives, their preparation and their use for the preparation of drug delivery systems are described. Preferred nanoparticles comprise at least one starch derivate, wherein the starch derivative is a hydrophobic starch derivative with an average degree of substitution of the hydroxyl-groups (Ds) in the range of 0.5 to 2.75.
Inventors:
SANTANDER ORTEGA MANUEL J (GB)
STAUNER THOMAS (DE)
LORETZ BRIGITTA (DE)
WENZ GERHARD (DE)
SCHAEFER ULRICH (DE)
LEHR CLAUS-MICHAEL (DE)
STAUNER THOMAS (DE)
LORETZ BRIGITTA (DE)
WENZ GERHARD (DE)
SCHAEFER ULRICH (DE)
LEHR CLAUS-MICHAEL (DE)
Application Number:
PCT/EP2010/050488
Publication Date:
April 14, 2011
Filing Date:
January 18, 2010
Export Citation:
Assignee:
BASF SE (DE)
SANTANDER ORTEGA MANUEL J (GB)
STAUNER THOMAS (DE)
LORETZ BRIGITTA (DE)
WENZ GERHARD (DE)
SCHAEFER ULRICH (DE)
LEHR CLAUS-MICHAEL (DE)
SANTANDER ORTEGA MANUEL J (GB)
STAUNER THOMAS (DE)
LORETZ BRIGITTA (DE)
WENZ GERHARD (DE)
SCHAEFER ULRICH (DE)
LEHR CLAUS-MICHAEL (DE)
International Classes:
A61K9/51; A61K47/36; C08B31/00
Domestic Patent References:
| WO2005030844A1 | 2005-04-07 |
Foreign References:
| DE19857995A1 | 2000-06-21 |
Other References:
TUOVINEN L ET AL: "Starch acetate microparticles for drug delivery into retinal pigment epithelium-in vitro study", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 98, no. 3, 27 August 2004 (2004-08-27), pages 407 - 413, XP004527193, ISSN: 0168-3659, DOI: DOI:10.1016/J.JCONREL.2004.05.016
SIMI C K ET AL: "Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery", BIOPROCESS AND BIOSYSTEMS ENGINEERING, SPRINGER, BERLIN, DE, vol. 30, no. 3, 4 February 2007 (2007-02-04), pages 173 - 180, XP019518083, ISSN: 1615-7605, DOI: DOI:10.1007/S00449-007-0112-5
NURMI ET AL: "Controlled grafting of acetylated starch by atom transfer radical polymerization of MMA", EUROPEAN POLYMER JOURNAL, PERGAMON PRESS LTD. OXFORD, GB, vol. 43, no. 4, 29 March 2007 (2007-03-29), pages 1372 - 1382, XP022008176, ISSN: 0014-3057, DOI: DOI:10.1016/J.EURPOLYMJ.2007.01.038
SIMI C K ET AL: "Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery", BIOPROCESS AND BIOSYSTEMS ENGINEERING, SPRINGER, BERLIN, DE, vol. 30, no. 3, 4 February 2007 (2007-02-04), pages 173 - 180, XP019518083, ISSN: 1615-7605, DOI: DOI:10.1007/S00449-007-0112-5
NURMI ET AL: "Controlled grafting of acetylated starch by atom transfer radical polymerization of MMA", EUROPEAN POLYMER JOURNAL, PERGAMON PRESS LTD. OXFORD, GB, vol. 43, no. 4, 29 March 2007 (2007-03-29), pages 1372 - 1382, XP022008176, ISSN: 0014-3057, DOI: DOI:10.1016/J.EURPOLYMJ.2007.01.038
Attorney, Agent or Firm:
BASF SE (67056 Ludwigshafen, DE)
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