Title:
STAT3 TRANSCRIPTION FACTOR INHIBITORS AND METHODS OF USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2020/118265
Kind Code:
A3
Abstract:
Compounds that inhibit the activity of Signal transducer and activator of transcription 3 (STAT3), or pharmaceutically acceptable salts or prodrugs thereof, and methods of using these compounds to treat cancer and other diseases.
Inventors:
AMAYA MARIA L (US)
REIGAN PHILIP (US)
BACKOS DONALD S (US)
MATHESON CHRISTOPHER J (US)
FURTEK STEFFANIE L (US)
JORDAN CRAIG T (US)
REIGAN PHILIP (US)
BACKOS DONALD S (US)
MATHESON CHRISTOPHER J (US)
FURTEK STEFFANIE L (US)
JORDAN CRAIG T (US)
Application Number:
PCT/US2019/065085
Publication Date:
July 30, 2020
Filing Date:
December 06, 2019
Export Citation:
Assignee:
UNIV COLORADO REGENTS (US)
REIGAN PHILIP (US)
BACKOS DONALD S (US)
MATHESON CHRISTOPHER J (US)
FURTEK STEFFANIE L (US)
JORDAN CRAIG T (US)
AMAYA MARIA L (US)
REIGAN PHILIP (US)
BACKOS DONALD S (US)
MATHESON CHRISTOPHER J (US)
FURTEK STEFFANIE L (US)
JORDAN CRAIG T (US)
AMAYA MARIA L (US)
International Classes:
C07D233/26; A61K31/341; A61P35/00; C07C233/66; C07D263/32; C07D263/57; C07D307/16; C07D307/54; C07D307/56; C07D307/58; C07D307/66; C07D307/68; C07D307/80
Foreign References:
| CN109053480A | 2018-12-21 |
Other References:
STEFFANIE L. FURTEK ET AL: "Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors", ONCOTARGET, vol. 7, no. 47, 22 November 2016 (2016-11-22), United States, pages 77998 - 78008, XP055662999, ISSN: 1949-2553, DOI: 10.18632/oncotarget.12868
ROBERT A MOOK R ET AL: "Structure-activity studies of Wnt/beta-catenin inhibition in the Niclosamide chemotype: identification of derivatives with improved drug exposure", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, ELSEVIER, NL, vol. 23, 1 January 2015 (2015-01-01), pages 5829 - 5838, XP002778786, ISSN: 0968-0896
DATABASE Pubchem compound [online] 8 July 2005 (2005-07-08), XP002797273, retrieved from NCBI Database accession no. 817996
LEMAIRE H ET AL: "Synthesis and germicidal activity of halogenated salicylanilides and related compounds", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 50, no. 10, 1 October 1961 (1961-10-01), pages 831 - 837, XP002558442, ISSN: 0022-3549, [retrieved on 20060921], DOI: 10.1002/JPS.2600501006
DAOSHAN YANG ET AL: "Copper-Catalyzed Domino Synthesis of Benzimidazo[2,1-b]quin- azolin-12(6H)-ones Using Cyanamide as a Building Block", ADVANCED SYNTHESIS & CATALYSIS, vol. 354, no. 2-3, 1 February 2012 (2012-02-01), DE, pages 477 - 482, XP055663724, ISSN: 1615-4150, DOI: 10.1002/adsc.201100580
ZHEN-WEI ZHU ET AL: "Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 26, no. 1, 28 June 2010 (2010-06-28), GB, pages 37 - 45, XP055663729, ISSN: 1475-6366, DOI: 10.3109/14756361003671060
RYOSUKE FUKAI ET AL: "Design and Synthesis of Novel Cyclooxygenase-1 Inhibitors as Analgesics: 5-Amino-2-ethoxy- N -(substituted-phenyl)benzamides", CHEMMEDCHEM, vol. 6, no. 3, 7 March 2011 (2011-03-07), DE, pages 550 - 560, XP055663733, ISSN: 1860-7179, DOI: 10.1002/cmdc.201000462
ROBERT A MOOK R ET AL: "Structure-activity studies of Wnt/beta-catenin inhibition in the Niclosamide chemotype: identification of derivatives with improved drug exposure", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, ELSEVIER, NL, vol. 23, 1 January 2015 (2015-01-01), pages 5829 - 5838, XP002778786, ISSN: 0968-0896
DATABASE Pubchem compound [online] 8 July 2005 (2005-07-08), XP002797273, retrieved from NCBI Database accession no. 817996
LEMAIRE H ET AL: "Synthesis and germicidal activity of halogenated salicylanilides and related compounds", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 50, no. 10, 1 October 1961 (1961-10-01), pages 831 - 837, XP002558442, ISSN: 0022-3549, [retrieved on 20060921], DOI: 10.1002/JPS.2600501006
DAOSHAN YANG ET AL: "Copper-Catalyzed Domino Synthesis of Benzimidazo[2,1-b]quin- azolin-12(6H)-ones Using Cyanamide as a Building Block", ADVANCED SYNTHESIS & CATALYSIS, vol. 354, no. 2-3, 1 February 2012 (2012-02-01), DE, pages 477 - 482, XP055663724, ISSN: 1615-4150, DOI: 10.1002/adsc.201100580
ZHEN-WEI ZHU ET AL: "Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 26, no. 1, 28 June 2010 (2010-06-28), GB, pages 37 - 45, XP055663729, ISSN: 1475-6366, DOI: 10.3109/14756361003671060
RYOSUKE FUKAI ET AL: "Design and Synthesis of Novel Cyclooxygenase-1 Inhibitors as Analgesics: 5-Amino-2-ethoxy- N -(substituted-phenyl)benzamides", CHEMMEDCHEM, vol. 6, no. 3, 7 March 2011 (2011-03-07), DE, pages 550 - 560, XP055663733, ISSN: 1860-7179, DOI: 10.1002/cmdc.201000462
Attorney, Agent or Firm:
PAVAO, Matthew et al. (US)
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