Title:
STEAROYL AMINO ACID SALT, AND PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/103901
Kind Code:
A1
Abstract:
Disclosed is a stearoyl amino acid salt. The stearoyl amino acid salt has a structural formula represented by a general formula (I), R1 indicating H or an aromatic base capable of substituted by one or more substituents, or C1-4 straight chains or alkyl with a branched chain, the substituent being an alcoholic hydroxyl group or a phenolic hydroxyl group, and R2 indicating C11-25 saturated or unsaturated aliphatic groups. Also disclosed are a preparation method and uses of the stearoyl amino acid salt. Compared with a prototype drug stearoyl amino acid, the stearoyl amino acid salt of the present invention has excellent physicochemical properties, good stability, high relative bioavailability, a strong drug effect and a high safety factor, is expected to become a candidate for clinical treatment of neurodegenerative diseases and acute brain injury, and is expected to become a clinic drug for weight loss, and has very broad application prospects.
Inventors:
LU YANG (CN)
LIU JIANHUA (CN)
TANG SHUANGQI (CN)
LIU JIANHUA (CN)
TANG SHUANGQI (CN)
Application Number:
PCT/CN2014/090381
Publication Date:
July 16, 2015
Filing Date:
November 05, 2014
Export Citation:
Assignee:
SHANGHAI JIAOTONG UNIV SCHOOL MEDICINE (CN)
International Classes:
C07C233/47; A61K31/198; A61P1/16; A61P3/04; A61P9/10; A61P25/00; A61P25/16; A61P25/28; C07C231/12
Foreign References:
| CN1974545A | 2007-06-06 | |||
| CN101743242A | 2010-06-16 | |||
| CN101674852A | 2010-03-17 | |||
| CN101240002A | 2008-08-13 | |||
| CN103980148A | 2014-08-13 |
Other References:
ZEELEN, F.J. ET AL.: "Synthesis of Stearoylamino Acids", RECL. TRAV. CHIM., vol. 77, 31 December 1958 (1958-12-31), pages 267 - 272, XP002743404, DOI: doi:10.1002/recl.19580770308
YANG, RUI: "Study on The Neuroprotection of Stearoyltyrosinate on Caspaseindependent Podocyte Injury and the Mechanisms Thereof", DOCTORAL DISSERTATIONS OF SHANGHAI JIAOTONG UNIVERSITY, 31 May 2013 (2013-05-31)
GUO, QINGYU: "The Biochemical Mechanism of Endocannabinoid System in Type 2 Diabetes and Obesity", CHINESE JOURNAL OF GERIATRIC CARE, vol. 6, no. 6, 31 December 2008 (2008-12-31), pages 5
YANG, RUI: "Study on The Neuroprotection of Stearoyltyrosinate on Caspaseindependent Podocyte Injury and the Mechanisms Thereof", DOCTORAL DISSERTATIONS OF SHANGHAI JIAOTONG UNIVERSITY, 31 May 2013 (2013-05-31)
GUO, QINGYU: "The Biochemical Mechanism of Endocannabinoid System in Type 2 Diabetes and Obesity", CHINESE JOURNAL OF GERIATRIC CARE, vol. 6, no. 6, 31 December 2008 (2008-12-31), pages 5
Attorney, Agent or Firm:
SHULUN & PARTNERS (SHANGHAI) (CN)
上海序伦律师事务所 (CN)
上海序伦律师事务所 (CN)
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