STERILE FILLING MACHINE HAVING NEEDLE FILLING STATION WITHIN E-BEAM CHAMBER

WIPO Patent Application WO2004000100

A3

A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a heat resealable stopper and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the stopper and chamber for sterilizing the container. The previously sterilized containers are then transported through an e-beam chamber, wherein an electron beam is directed onto a penetrable surface of the stopper to sterilize the penetrable surface. A needle is mounted within the e-beam chamber and moved into engagement with the stopper to pierce the sterilized penetrable surface of the stopper and inject the substance through the needle and into the chamber of the container. The needle is then withdrawn from the stopper and the filled container is transported outside of the e-beam chamber. Laser energy is then transmitted onto the penetrated surface of the stopper to fuse the stopper material and hermetically re-seal the stopper.

WO/2010/121775	METHOD AND DEVICE FOR MONITORING THE INTENSITY OF AN ELECTRON BEAM
WO/1987/001551	METHOD AND APPARATUS FOR REDUCING VISCOSITY OF HIGH VISCOSITY MATERIALS
JP5086295	A device for irradiating and mixing the fluid in the container

PY DANIEL (US)

PCT/US2003/019656

April 22, 2004

June 19, 2003

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MEDICAL INSTILL TECH INC (US)
PY DANIEL C (US)

A61L2/08; B65B1/04; B65B55/08; B65B3/04; B65B7/28; B65B55/02; B65B55/04; B67C3/00; A61B; (IPC1-7): B65B1/04; B65B3/04; B67C3/00

US6604561B2	2003-08-12
US5641004A	1997-06-24
US5484566A	1996-01-16
US5129212A	1992-07-14
US4390111A	1983-06-28

See also references of EP 1517834A4

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