Title:
STEROID COMPOUND, AND MEDICINE COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2014/057957
Kind Code:
A1
Abstract:
Provided are: a novel steroid compound useful for a diagnostic medicine; and a medicine comprising the steroid compound.
A steroid compound represented by formula (1) (wherein R1 represents a hydroxy group, a sulfonyloxy-type protected hydroxy group, a halogen atom, a radioactive isotope, or a group containing a radioactive isotope; R2 and R3 may be the same as or different from each other and independently represent a hydrogen atom or a protective group for a hydroxy group; and n represents an integer of 0 to 3 or 5); and a medicine comprising the steroid compound.
Inventors:
OKAMOTO MAYUMI (JP)
SHIMIZU ISAO (JP)
TOYOHARA JUN (JP)
ISHIWATA KIICHI (JP)
ODA KEIICHI (JP)
SAKATA MUNEYUKI (JP)
SHINOZAKI KOZO (JP)
TONEGAWA FUMIO (JP)
SHIMIZU ISAO (JP)
TOYOHARA JUN (JP)
ISHIWATA KIICHI (JP)
ODA KEIICHI (JP)
SAKATA MUNEYUKI (JP)
SHINOZAKI KOZO (JP)
TONEGAWA FUMIO (JP)
Application Number:
PCT/JP2013/077403
Publication Date:
April 17, 2014
Filing Date:
October 08, 2013
Export Citation:
Assignee:
UNIV WASEDA (JP)
TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INST OF GERONTOLOGY (JP)
JUNSEI CHEMICAL (JP)
TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INST OF GERONTOLOGY (JP)
JUNSEI CHEMICAL (JP)
International Classes:
C07J1/00; A61K31/565; A61K51/00; A61P15/00; A61P35/00
Domestic Patent References:
| WO2010043404A1 | 2010-04-22 |
Foreign References:
| US20090082323A1 | 2009-03-26 | |||
| JPS6097995A | 1985-05-31 | |||
| US6500669B1 | 2002-12-31 |
Other References:
FRENCH,A.N. ET AL.: "A synthesis of 7?-substituted estradiols: synthesis and biological evaluation of a 7?-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7?-pentylestradiol analog", STEROIDS, vol. 58, no. 4, April 1993 (1993-04-01), pages 157 - 169
DASILVA,J.N. ET AL.: "In vivo evaluation of 7?-[11-(4-[125I]Iodophenoxy)undecyl]-17?-estradiol: A potential vector for therapy of adrenal and estrogen receptor-positive cancers", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 37, no. 1, September 1990 (1990-09-01), pages 77 - 83
HOFFMAN,K.L. ET AL.: "The terminal substituents of 7?, 6-hexanyl derivatives of estradiol determine their selective estrogen receptor modulator versus agonist activities", STEROIDS, vol. 77, no. 5, April 2012 (2012-04-01), pages 496 - 503
JIANG,X.R. ET AL.: "Synthesis of 7?-substituted derivatives of 17?-estradiol", STEROIDS, vol. 71, no. 5, May 2006 (2006-05-01), pages 334 - 342
BUCOURT,R. ET AL.: "New biospecific adsorbents for the purification of estradiol receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 253, no. 22, 1978, pages 8221 - 8228
CYRUS,K. ET AL.: "Two-Headed PROTAC: An Effective New Tool for Targeted Protein Degradation", CHEMBIOCHEM, vol. 11, no. 11, 26 July 2010 (2010-07-26), pages 1531 - 1534
AHMED,N. ET AL.: "Molecular iodine in isopropenyl acetate (IPA): a highly efficient catalyst for the acetylation of alcohols, amines and phenols under solvent free conditions", TETRAHEDRON LETTERS, vol. 47, no. 30, 24 July 2006 (2006-07-24), pages 5345 - 5349
LABAREE,D.C. ET AL.: "Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 1886 - 1904
MITRA,K. ET AL.: "A Rationally Designed Genotoxin that Selectively Destroys Estrogen Receptor-Positive Breast Cancer Cells", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 124, no. 9, 2002, pages 1862 - 1863
SKADDAN,M.B. ET AL.: "Synthesis and Binding Affinities of Novel Re-Containing 7?-Substituted Estradiol Complexes:? Models for Breast Cancer Imaging Agents", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 22, 1999, pages 8108 - 8121
KUNZER,H. ET AL.: "Stereocontrolled derivatization of 3-methoxyestra-1,3,5(10), n-tetraenes via lewis acid promoted prins reactions, (n=7; 8(9))", TETRAHEDRON LETTERS, vol. 32, no. 6, 4 February 1991 (1991-02-04), pages 743 - 746
DASILVA,J.N. ET AL.: "In vivo evaluation of 7?-[11-(4-[125I]Iodophenoxy)undecyl]-17?-estradiol: A potential vector for therapy of adrenal and estrogen receptor-positive cancers", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 37, no. 1, September 1990 (1990-09-01), pages 77 - 83
HOFFMAN,K.L. ET AL.: "The terminal substituents of 7?, 6-hexanyl derivatives of estradiol determine their selective estrogen receptor modulator versus agonist activities", STEROIDS, vol. 77, no. 5, April 2012 (2012-04-01), pages 496 - 503
JIANG,X.R. ET AL.: "Synthesis of 7?-substituted derivatives of 17?-estradiol", STEROIDS, vol. 71, no. 5, May 2006 (2006-05-01), pages 334 - 342
BUCOURT,R. ET AL.: "New biospecific adsorbents for the purification of estradiol receptor", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 253, no. 22, 1978, pages 8221 - 8228
CYRUS,K. ET AL.: "Two-Headed PROTAC: An Effective New Tool for Targeted Protein Degradation", CHEMBIOCHEM, vol. 11, no. 11, 26 July 2010 (2010-07-26), pages 1531 - 1534
AHMED,N. ET AL.: "Molecular iodine in isopropenyl acetate (IPA): a highly efficient catalyst for the acetylation of alcohols, amines and phenols under solvent free conditions", TETRAHEDRON LETTERS, vol. 47, no. 30, 24 July 2006 (2006-07-24), pages 5345 - 5349
LABAREE,D.C. ET AL.: "Synthesis and Evaluation of B-, C-, and D-Ring-Substituted Estradiol Carboxylic Acid Esters as Locally Active Estrogens", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, 2003, pages 1886 - 1904
MITRA,K. ET AL.: "A Rationally Designed Genotoxin that Selectively Destroys Estrogen Receptor-Positive Breast Cancer Cells", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 124, no. 9, 2002, pages 1862 - 1863
SKADDAN,M.B. ET AL.: "Synthesis and Binding Affinities of Novel Re-Containing 7?-Substituted Estradiol Complexes:? Models for Breast Cancer Imaging Agents", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 22, 1999, pages 8108 - 8121
KUNZER,H. ET AL.: "Stereocontrolled derivatization of 3-methoxyestra-1,3,5(10), n-tetraenes via lewis acid promoted prins reactions, (n=7; 8(9))", TETRAHEDRON LETTERS, vol. 32, no. 6, 4 February 1991 (1991-02-04), pages 743 - 746
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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