Title:
STEROID CONTAINING COMPOSITION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/131038
Kind Code:
A3
Abstract:
The present invention provides the use of a steroid in combination with an anti-oxidant or an inhibitor of forkhead signalling, in particular, for the treatment, amelioration or prevention of tissue degeneration and/or pain and/or inflammation and/or for facilitating tissue repair. The invention also provides a composition comprising a steroid and an anti-oxidant or an inhibitor of forkhead signalling.
Inventors:
HULLEY PHILIPA (GB)
POULSEN RAEWYN (GB)
CARR ANDREW (GB)
POULSEN RAEWYN (GB)
CARR ANDREW (GB)
Application Number:
PCT/GB2010/050776
Publication Date:
January 06, 2011
Filing Date:
May 12, 2010
Export Citation:
Assignee:
ISIS INNOVATION (GB)
HULLEY PHILIPA (GB)
POULSEN RAEWYN (GB)
CARR ANDREW (GB)
HULLEY PHILIPA (GB)
POULSEN RAEWYN (GB)
CARR ANDREW (GB)
International Classes:
A61K31/375; A61K31/445; A61K31/573; A61P25/04
Domestic Patent References:
| WO2008104186A1 | 2008-09-04 |
Foreign References:
| US4080448A | 1978-03-21 | |||
| RO108413B1 | 1994-05-31 | |||
| US20060194759A1 | 2006-08-31 | |||
| FR2189M | ||||
| ES2316312A1 | 2009-04-01 | |||
| US6352691B1 | 2002-03-05 | |||
| US20060045850A1 | 2006-03-02 | |||
| GB2180750A | 1987-04-08 | |||
| US6767534B1 | 2004-07-27 | |||
| US20030232797A1 | 2003-12-18 |
Other References:
DATABASE WPI Week 200701, Derwent World Patents Index; AN 2007-000489, XP002592319
SCHAFER S C ET AL: "Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles", January 2005, AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY 200501 US LNKD- DOI:10.1152/AJPHEART.00587.2004, VOL. 288, NR. 1 57-1, PAGE(S) H436-H444, ISSN: 0363-6135, XP002592320
OHTSUKA A ET AL: "Vitamin E reduces glucocorticoid-induced oxidative stress in rat skeletal muscle.", December 1998, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY DEC 1998 LNKD- PUBMED:10197309, VOL. 44, NR. 6, PAGE(S) 779 - 786, ISSN: 0301-4800, XP009136238
BEHL ET AL: "Glucocorticoids Enhance Oxidative Stress-Induced Cell Death in Hippocampal Neurons in Vitro", ENDOCRINOLOGY SOCIETY, BALTIMORE, MD, US LNKD- DOI:10.1210/EN.138.1.101, vol. 138, no. 1, 1 January 1997 (1997-01-01), pages 101 - 106, XP002080518, ISSN: 0013-7227
DATABASE WPI Week 200020, Derwent World Patents Index; AN 2000-237766, XP002607367
DATABASE WPI Week 198730, Derwent World Patents Index; AN 1987-210760, XP002607368
SCHAFER S C ET AL: "Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles", January 2005, AMERICAN JOURNAL OF PHYSIOLOGY - HEART AND CIRCULATORY PHYSIOLOGY 200501 US LNKD- DOI:10.1152/AJPHEART.00587.2004, VOL. 288, NR. 1 57-1, PAGE(S) H436-H444, ISSN: 0363-6135, XP002592320
OHTSUKA A ET AL: "Vitamin E reduces glucocorticoid-induced oxidative stress in rat skeletal muscle.", December 1998, JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY DEC 1998 LNKD- PUBMED:10197309, VOL. 44, NR. 6, PAGE(S) 779 - 786, ISSN: 0301-4800, XP009136238
BEHL ET AL: "Glucocorticoids Enhance Oxidative Stress-Induced Cell Death in Hippocampal Neurons in Vitro", ENDOCRINOLOGY SOCIETY, BALTIMORE, MD, US LNKD- DOI:10.1210/EN.138.1.101, vol. 138, no. 1, 1 January 1997 (1997-01-01), pages 101 - 106, XP002080518, ISSN: 0013-7227
DATABASE WPI Week 200020, Derwent World Patents Index; AN 2000-237766, XP002607367
DATABASE WPI Week 198730, Derwent World Patents Index; AN 1987-210760, XP002607368
Attorney, Agent or Firm:
BARKER BRETTELL LLP (EdgbastonBirmingham, West Midlands B16 8QQ, GB)
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