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Title:
STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154247
Kind Code:
A1
Abstract:
The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound as shown in formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.

Inventors:
SU, Yidong (Economic and Technological Development Zone, Lianyungang, Jiangsu 7, 222047, CN)
CHEN, Xiaopo (Economic and Technological Development Zone, Lianyungang, Jiangsu 7, 222047, CN)
WANG, Jun (Economic and Technological Development Zone, Lianyungang, Jiangsu 7, 222047, CN)
BAO, Rudi (Economic and Technological Development Zone, Lianyungang, Jiangsu 7, 222047, CN)
Application Number:
CN2019/074108
Publication Date:
August 15, 2019
Filing Date:
January 31, 2019
Export Citation:
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Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (Economic and Technological Development Zone, Lianyungang, Jiangsu 7, 222047, CN)
SHANGHAI HANSOH BIOMEDICAL CO., LTD. (Building 2, No.3728 Jinke Road Zhangjiang Hi-Tech Park, Shanghai 3, 201203, CN)
International Classes:
C07J3/00; A61K31/57; A61K31/573; A61K31/58; A61P25/00; C07J5/00; C07J7/00; C07J17/00; C07J43/00
Domestic Patent References:
WO2013019711A22013-02-07
WO2016061537A12016-04-21
WO2014169831A12014-10-23
Foreign References:
TW201629015A2016-08-16
CN104136452A2014-11-05
CN105339381A2016-02-17
Other References:
COVEY, D.F. ET AL.: "Neurosteroid Analogues. 8.Structure Activity Studies of N-Acylated 17a-Aza-D-Homosteroid Analogues of the Anesthetic Steroids (3, 5)- and (3, 5)-3-Hydroxypregnan-20-one", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 17, 5 August 2000 (2000-08-05), pages 3201 - 3202, XP055151708
VELEIRO, A.S. ET AL.: "Synthesis and GABAA Receptor Activity of a 6, 19-Oxido Analogue of Pregnanolone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, 31 December 2003 (2003-12-31), pages 343 - 345
ANDERSON, A. ET AL.: "Conformationally Constrained Anesthetic Steroids that Modulate GABAA Receptors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, 19 October 2000 (2000-10-19), pages 4118 - 4121, XP002248656
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (David W. Cheng, Level 19 Tower E3, The Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District, Beijing 8, 100738, CN)
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