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Title:
STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154247
Kind Code:
A1
Abstract:
The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound as shown in formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.

Inventors:
SU YIDONG (CN)
CHEN XIAOPO (CN)
WANG JUN (CN)
BAO RUDI (CN)
Application Number:
CN2019/074108
Publication Date:
August 15, 2019
Filing Date:
January 31, 2019
Export Citation:
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Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
C07J3/00; A61K31/57; A61K31/573; A61K31/58; A61P25/00; C07J5/00; C07J7/00; C07J17/00; C07J43/00
Domestic Patent References:
WO2013019711A22013-02-07
WO2016061537A12016-04-21
WO2014169831A12014-10-23
Foreign References:
TW201629015A2016-08-16
CN104136452A2014-11-05
CN105339381A2016-02-17
Other References:
COVEY, D.F. ET AL.: "Neurosteroid Analogues. 8.Structure Activity Studies of N-Acylated 17a-Aza-D-Homosteroid Analogues of the Anesthetic Steroids (3, 5)- and (3, 5)-3-Hydroxypregnan-20-one", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 17, 5 August 2000 (2000-08-05), pages 3201 - 3202, XP055151708
ADRIANA SVELEIRO , RUTH E ROSENSTEIN ,CAROLINA O JALIFFA ,MARÍA L GRILLI ,FLORENCIA SPERONI ,GERARDO BURTON: "Synthesis and GABAA Receptor Activity of a 6, 19-Oxido Analogue of Pregnanolone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 3, 10 February 2003 (2003-02-10), pages 343 - 345, XP055721845, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(02)01019-3
ANDERSON, A. ET AL.: "Conformationally Constrained Anesthetic Steroids that Modulate GABAA Receptors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, 19 October 2000 (2000-10-19), pages 4118 - 4121, XP002248656
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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