Title:
STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/154257
Kind Code:
A1
Abstract:
The present invention relates to steroid derivative regulators, a method for preparing the same, and uses thereof. Specifically, the present invention relates to a compound of formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator the of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases, wherein the substituents of the formula (I) are as defined in the description.
Inventors:
SU YIDONG (CN)
DENG HAINING (CN)
CHEN XIAOPO (CN)
BAO RUDI (CN)
ZHANG FUJUN (CN)
DENG HAINING (CN)
CHEN XIAOPO (CN)
BAO RUDI (CN)
ZHANG FUJUN (CN)
Application Number:
PCT/CN2019/074134
Publication Date:
August 15, 2019
Filing Date:
January 31, 2019
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
A61K31/57; C07J3/00; A61K31/573; A61K31/58; A61P25/00; C07J5/00; C07J7/00; C07J17/00; C07J43/00
Domestic Patent References:
| WO1993003732A1 | 1993-03-04 | |||
| WO2014169831A1 | 2014-10-23 | |||
| WO2016061537A1 | 2016-04-21 | |||
| WO2003077919A1 | 2003-09-25 | |||
| WO2014169833A1 | 2014-10-23 | |||
| WO2016061537A1 | 2016-04-21 | |||
| WO2015180679A1 | 2015-12-03 | |||
| WO2015027227A1 | 2015-02-26 |
Foreign References:
| CN105339381A | 2016-02-17 | |||
| CN104136452A | 2014-11-05 |
Other References:
RN: 198127-90-1 STN: REGISTRY 19971205
RN: 891488-64-55 STN: REGISTRY 20060710
RN: 172786-97-9 STN: REGISTRY 19960131
RN: 124651-21-4 STN: REGISTRY 19900112
RN: 112090-78-5 STN: REGISTRY 19880101
RN: 102341-22-0 STN: REGISTRY 19860526
RN: 2049390-35-2 STN: REGISTRY 20161215
RN: 886995-52-4 STN: REGISTRY 20060606
RN: 158599-84-9, 158599-80-5 STN: REGISTRY 19941028
RN: 116627-33-9, 116627-32-8 STN: REGISTRY 19880925
RN: 102020-94-0, 102020-83-7 STN: REGISTRY 19860510
RN: 151313-10-9, 151313-07-4, 151313-09-6 STN: REGISTRY 19931118
RN: 74824-68-3, 7438-72-4, 2685-16-7, 3262-30-4, 2701-40-8, 10329-87-0, 2684-47-1, 7001-64-1, 1667-98-7 STN: REGISTRY 19841116
ANDERSON, A. ET AL.: "Conformationally Constrained Anesthetic Steroids That Modulate GABAA Receptors", J. MED. CHEM., vol. 43, no. 22, 19 October 2000 (2000-10-19), pages 4118 - 4121, XP002248656, DOI: 10.1021/jm000977e
VELEIRO, A.S. ET A.: "Synthesis and GABAA Receptor Acitivity of a6, 19-Oxido Analogue of Pregnanolone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 3, 31 December 2003 (2003-12-31), pages 343 - 345, XP055721845
GALOFRE, M. ET AL.: "GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity", NEUROTOXICOLOGY AND TERATOLOGY, vol. 32, no. 1, 10 February 2009 (2009-02-10), pages 52 - 61, XP026851004
See also references of EP 3750908A4
RN: 891488-64-55 STN: REGISTRY 20060710
RN: 172786-97-9 STN: REGISTRY 19960131
RN: 124651-21-4 STN: REGISTRY 19900112
RN: 112090-78-5 STN: REGISTRY 19880101
RN: 102341-22-0 STN: REGISTRY 19860526
RN: 2049390-35-2 STN: REGISTRY 20161215
RN: 886995-52-4 STN: REGISTRY 20060606
RN: 158599-84-9, 158599-80-5 STN: REGISTRY 19941028
RN: 116627-33-9, 116627-32-8 STN: REGISTRY 19880925
RN: 102020-94-0, 102020-83-7 STN: REGISTRY 19860510
RN: 151313-10-9, 151313-07-4, 151313-09-6 STN: REGISTRY 19931118
RN: 74824-68-3, 7438-72-4, 2685-16-7, 3262-30-4, 2701-40-8, 10329-87-0, 2684-47-1, 7001-64-1, 1667-98-7 STN: REGISTRY 19841116
ANDERSON, A. ET AL.: "Conformationally Constrained Anesthetic Steroids That Modulate GABAA Receptors", J. MED. CHEM., vol. 43, no. 22, 19 October 2000 (2000-10-19), pages 4118 - 4121, XP002248656, DOI: 10.1021/jm000977e
VELEIRO, A.S. ET A.: "Synthesis and GABAA Receptor Acitivity of a6, 19-Oxido Analogue of Pregnanolone", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 3, 31 December 2003 (2003-12-31), pages 343 - 345, XP055721845
GALOFRE, M. ET AL.: "GABAA receptor and cell membrane potential as functional endpoints in cultured neurons to evaluate chemicals for human acute toxicity", NEUROTOXICOLOGY AND TERATOLOGY, vol. 32, no. 1, 10 February 2009 (2009-02-10), pages 52 - 61, XP026851004
See also references of EP 3750908A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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