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Title:
STEROID AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143398
Kind Code:
A1
Abstract:
Disclosed in the present invention are a steroid and a preparation method therefor and an application thereof. The steroid may have a structure as shown in formula II. The compound of the present invention has SREBP pathway inhibitory activity, and may be used for preventing and/or treating diseases such as obesity, hyperlipidemia, fatty liver, diabetes, atherosclerosis, cardiovascular and cerebrovascular diseases, liver cancer, and skin damage.

Inventors:
LIU JINBIAO (CN)
TANG JINGJIE (CN)
Application Number:
PCT/CN2023/073235
Publication Date:
August 03, 2023
Filing Date:
January 19, 2023
Export Citation:
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Assignee:
CHOLESGEN SHANGHAI CO LTD (CN)
International Classes:
C07J9/00; A61P3/06; A61P9/10; A61P9/12; C07J71/00
Foreign References:
CN109280069A2019-01-29
US20170247405A12017-08-31
CN1081682A1994-02-09
Other References:
IKUYA, S. ET AL.: "Luciferase-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano)sterols", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 28, no. 3, 1 February 2020 (2020-02-01), XP085979639, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.115298
DATABASE REGISTRY ANONYMOUS : "- Cholesta-5,23-diene-3,25-diol, (3.beta.)- (CA INDEX NAME)", XP093084050, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 26,27-Dinorergostane-3,24-diol, 5,6-epoxy-, (3.beta.,5.alpha.,6.alpha.)- (CA INDEX NAME)", XP093084053, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,7,25-triol, 7-(trifluoromethyl)-, (3.beta.,7.beta.)- (CA INDEX NAME) ", XP093084054, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,7,25-triol, 7-(trifluoromethyl)-, (3.beta.,7.alpha.)- (CA INDEX NAME)", XP093084056, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 26,27-Dinorergost-5-ene-3,19,24-triol, (3.beta.)- (CA INDEX NAME)", XP093084057, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,19,25-triol, (3.beta.)- (CA INDEX NAME)", XP093084058, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 26,27-Dinorergost-5-ene-3,7,24-triol, 7-methyl-, (3.beta.)- (9CI) (CA INDEX NAME)", XP093084060, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 26,27-Dinorergost-5-ene-3,7,24-triol, 7-methyl-, (3.beta.,7.beta.)- (9CI) (CA INDEX NAME)", XP093084063, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 26,27-Dinorergost-5-ene-3,7,24-triol, 7-methyl-, (3.beta.,7.alpha.)- (9CI) (CA INDEX NAME)", XP093084066, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,25-diol (CA INDEX NAME)", XP093084067, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,7,25-triol, (3.beta.)- (CA INDEX NAME)", XP093084069, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,25-diol, (3.alpha.)- (CA INDEX NAME)", XP093084071, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,7,25-triol, (3.beta.,7.alpha.)- (CA INDEX NAME)", XP093084072, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,7,25-triol, (3.beta.,7.beta.)- (CA INDEX NAME)", XP093084076, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Cholest-5-ene-3,25-diol, (3.beta.,20S)- (9CI) (CA INDEX NAME)", XP093084081, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 26,27-Dinorergost-5-ene-3,24-diol, (3.beta.)- (CA INDEX NAME)", XP093084082, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- 24-Norchol-5-ene-3,23-diol, (3.beta.)- (CA INDEX NAME)", XP093084084, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "- Chol-5-ene-3,24-diol, (3.beta.)- (CA INDEX NAME)", XP093084085, retrieved from STN
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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