Title:
STEROL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/010682
Kind Code:
A1
Abstract:
Disclosed is a sterol derivative, which has an effect of promoting the proliferation of nerve stem cells, or a pharmaceutically acceptable salt of the same. Specifically disclosed is a sterol derivative represented by general formula (I) [wherein Y represents an optionally substituted lower alkyl, etc.; Xa and Xb are the same or different and represent a bond, etc.; R1, R2, R3, R4, R7 and R8 are the same or different and represent a hydrogen atom, etc.; R5 and R6 are the same or different and represent a hydrogen atom, etc.; R9 represents a hydrogen atom, etc.; R10 and R11 together form a bond, etc.; and R12 represents a hydrogen atom, etc.], a pharmaceutically acceptable salt of the same, or the like.
Inventors:
UCHIDA KENJI
AGATSUMA TSUTOMU
HIBINO KAZUHIRO
SASHO SETSUYA
IIDA KYOICHIRO
ONODERA HIDEYUKI
AGATSUMA TSUTOMU
HIBINO KAZUHIRO
SASHO SETSUYA
IIDA KYOICHIRO
ONODERA HIDEYUKI
Application Number:
PCT/JP2010/062297
Publication Date:
January 27, 2011
Filing Date:
July 22, 2010
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
UCHIDA KENJI
AGATSUMA TSUTOMU
HIBINO KAZUHIRO
SASHO SETSUYA
IIDA KYOICHIRO
ONODERA HIDEYUKI
UCHIDA KENJI
AGATSUMA TSUTOMU
HIBINO KAZUHIRO
SASHO SETSUYA
IIDA KYOICHIRO
ONODERA HIDEYUKI
International Classes:
C07J73/00; A61K31/585; A61P9/00; A61P9/10; A61P21/02; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00
Domestic Patent References:
| WO2008154579A1 | 2008-12-18 | |||
| WO2009096445A1 | 2009-08-06 |
Foreign References:
| JP2006076948A | 2006-03-23 | |||
| JP2006076948A | 2006-03-23 |
Other References:
RODEWALD, W.J. ET AL.: "The ruthenium tetroxide oxidation of steroidal conjugated homoannular dienes", TETRAHEDRON LETTERS, 1979, pages 3119 - 3122, XP008149412
MORISAWA, Y. ET AL.: "Part XIV Synthesis of 6-aza- and 7-aza-5p-steroids", AGR. BIOL. CHEM., vol. 28, no. LL, 1964, pages 788 - 795, XP008149304
STEM CELLS, vol. 24, 2006, pages 1583 - 1593
THE JOURNAL OF NEUROSCIENCE, vol. 25, 2005, pages 4694 - 4705
NATURE REVIEWS NEUROSCIENCE, vol. 7, 2006, pages 395 - 406
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SCIENCE, vol. 301, 2003, pages 805 - 809
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 315, 2004, pages 493 - 496
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, 2006, pages 12673 - 12681
JOURNAL OF CELL SCIENCE, vol. 120, 2007, pages 1358 - 1370
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 28, 1964, pages 788 - 795
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
ORGANIC LETTERS, vol. 5, 2003, pages 1837 - 1839
CHEMISTRY-A EUROPEAN JOURNAL, vol. 7, 2001, pages 2663 - 2670
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, VCH VERLAGSGESELLSCHAFT MBH
THE JOURNAL OF NEUROSCIENCE, vol. 19, 1999, pages 8487 - 8497
GENES AND DEVELOPMENT, vol. 10, 1996, pages 3129 - 3140
EXPERIMENTAL CELL RESEARCH, vol. 289, 2003, pages 378 - 383
MORISAWA, Y. ET AL.: "Part XIV Synthesis of 6-aza- and 7-aza-5p-steroids", AGR. BIOL. CHEM., vol. 28, no. LL, 1964, pages 788 - 795, XP008149304
STEM CELLS, vol. 24, 2006, pages 1583 - 1593
THE JOURNAL OF NEUROSCIENCE, vol. 25, 2005, pages 4694 - 4705
NATURE REVIEWS NEUROSCIENCE, vol. 7, 2006, pages 395 - 406
JOURNAL OF BIOLOGY, vol. 1, 2002, pages 10
SCIENCE, vol. 301, 2003, pages 805 - 809
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCE OF THE UNITED STATES OFAMERICA, vol. 103, 2006, pages 8233 - 8238
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 315, 2004, pages 493 - 496
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, 2006, pages 12673 - 12681
JOURNAL OF CELL SCIENCE, vol. 120, 2007, pages 1358 - 1370
AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 28, 1964, pages 788 - 795
T. W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
ORGANIC LETTERS, vol. 5, 2003, pages 1837 - 1839
CHEMISTRY-A EUROPEAN JOURNAL, vol. 7, 2001, pages 2663 - 2670
R. C. LAROCK: "Comprehensive Organic Transformations", 1999, VCH VERLAGSGESELLSCHAFT MBH
THE JOURNAL OF NEUROSCIENCE, vol. 19, 1999, pages 8487 - 8497
GENES AND DEVELOPMENT, vol. 10, 1996, pages 3129 - 3140
EXPERIMENTAL CELL RESEARCH, vol. 289, 2003, pages 378 - 383
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