Title:
STEVIOL GLYCOSYLTRANSFERASE AND GENE ENCODING SAME
Document Type and Number:
WIPO Patent Application WO/2013/137487
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a steviol glycosyltransferase; and a method for producing a steviol glycoside using the enzyme.
The present invention provides: a steviol glycosyltransferase; and a method for producing a steviol glycoside using the enzyme. The present invention also provides: a transformant having, introduced therein, a steviol glycosyltransferase gene; and a method for producing the transformant.
Inventors:
ONO EIICHIRO (JP)
OCHIAI MISA (JP)
OCHIAI MISA (JP)
Application Number:
PCT/JP2013/058189
Publication Date:
September 19, 2013
Filing Date:
March 14, 2013
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
C12N15/09; A01H5/00; A23L1/30; A61K8/60; C07H15/256; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/10; C12P19/44
Domestic Patent References:
| WO2011153378A1 | 2011-12-08 | |||
| WO2013022989A2 | 2013-02-14 | |||
| WO2011153378A1 | 2011-12-08 |
Foreign References:
| JPH05255372A | 1993-10-05 | |||
| EP1897951B1 | 2010-12-15 | |||
| EP1897951B1 | 2010-12-15 | |||
| JPH05255372A | 1993-10-05 | |||
| JP2005287403A | 2005-10-20 | |||
| US6045996A | 2000-04-04 | |||
| US5925525A | 1999-07-20 | |||
| US5858659A | 1999-01-12 |
Other References:
HUMPHREY TV ET AL.: "Spatial organisation of four enzymes from Stevia rebaudiana that are involved in steviol glycoside synthesis", PLANT MOL. BIOL., vol. 61, no. 1-2, 2006, pages 47 - 62, XP019405427
RICHMAN A ET AL.: "Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana", PLANT. J., vol. 41, no. 1, 2005, pages 56 - 67, XP002686584
BRANDLE JE ET AL.: "Steviol glycoside biosynthesis", PHYTOCHEMISTRY, vol. 68, no. 14, 2007, pages 1855 - 1863, XP022145443
RYOJI KASAI ET AL.: "Stevia-ha no Kanmi Diterpene Haitotai - Rebaudioside -A, -D, -E Oyobi Kanren Haitotai no Gosei Narabini Kanmi to Kagaku Kozo tono Sokan", JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, 1981, pages 726 - 735, XP009039502
BRANDLE; TELMER, PHYTOCHEMISTRY, vol. 68, 2007, pages 1855 - 1863
RICHMAN ET AL., PLANT J., vol. 41, 2005, pages 56 - 67
MIZUTANI; OHTA, ANNU. REV. PLANT BIOL., vol. 61, 2010, pages 291 - 315
KASAI ET AL., BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 5, 1981, pages 726 - 735
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
SAMBROOK: "Molecular Cloning; A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR, LABORATORY PRESS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NAIL ACAD. SCI. USA, vol. 90, 1993, pages 5873
ALTSCHUL S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
MACKENZIE D. A., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 4655 - 4661
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
"Methods in yeast genetics", 2000, A COLD SPRING HARBOR LABORATORY COURSE MANUAL
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
HIROBUMI UCHIMIYA: "Manuals for Plant Gene Manipulation", 1990, KODANSHA SCIENTIFIC CO., LTD., pages: 27 - 31
NAGEL ET AL., MICRIBIOL. LETT., vol. 67, 1990, pages 325
GELVIN, S.B. ET AL.: "Plant Molecular Biology Manual", ACADEMIC PRESS PUBLISHERS
SAMBROOK; FRITSCH; MANIATIS: "Molecular Cloning: A Laboratory Manual 2nd Edition", 1989, COLD SPRING HARBOR LABORATORY PRESS
SIEBEN V.J. ET AL., IET NANOBIOTECHNOLOGY, vol. 1, no. 3, June 2007 (2007-06-01), pages 27 - 35
SAMBROOK ET AL.: "Molecular Cloning", 2001, COLD SPRING HARBOUR LABORATORY PRESS
RICHMAN A ET AL.: "Functional genomics uncovers three glucosyltransferases involved in the synthesis of the major sweet glucosides of Stevia rebaudiana", PLANT. J., vol. 41, no. 1, 2005, pages 56 - 67, XP002686584
BRANDLE JE ET AL.: "Steviol glycoside biosynthesis", PHYTOCHEMISTRY, vol. 68, no. 14, 2007, pages 1855 - 1863, XP022145443
RYOJI KASAI ET AL.: "Stevia-ha no Kanmi Diterpene Haitotai - Rebaudioside -A, -D, -E Oyobi Kanren Haitotai no Gosei Narabini Kanmi to Kagaku Kozo tono Sokan", JOURNAL OF THE CHEMICAL SOCIETY OF JAPAN, 1981, pages 726 - 735, XP009039502
BRANDLE; TELMER, PHYTOCHEMISTRY, vol. 68, 2007, pages 1855 - 1863
RICHMAN ET AL., PLANT J., vol. 41, 2005, pages 56 - 67
MIZUTANI; OHTA, ANNU. REV. PLANT BIOL., vol. 61, 2010, pages 291 - 315
KASAI ET AL., BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 5, 1981, pages 726 - 735
SAMBROOK; RUSSELL: "Molecular Cloning: A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR LABORATORY PRESS
AUSUBEL: "Current Protocols in Molecular Biology", 1987, JOHN WILEY & SONS
NUC. ACIDS. RES., vol. 10, 1982, pages 6487
PROC. NATL. ACAD. SCI. USA, vol. 79, 1982, pages 6409
GENE, vol. 34, 1985, pages 315
NUC. ACIDS. RES., vol. 13, 1985, pages 4431
PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
SAMBROOK: "Molecular Cloning; A Laboratory Manual", vol. 3, 2001, COLD SPRING HARBOR, LABORATORY PRESS
SCIENCE, vol. 227, no. 4693, 1985, pages 1435 - 1441
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264 - 2268
PROC. NAIL ACAD. SCI. USA, vol. 90, 1993, pages 5873
ALTSCHUL S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403
MARIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 337
JUNJI INOKOSHI ET AL., BIOCHEMISTRY, vol. 64, 1992, pages 660
HUSSAIN ET AL., GENE, vol. 101, 1991, pages 149
MACKENZIE D. A., APPL. ENVIRON. MICROBIOL., vol. 66, 2000, pages 4655 - 4661
PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929
J. BACTERIOLOGY, vol. 153, 1983, pages 163
"Methods in yeast genetics", 2000, A COLD SPRING HARBOR LABORATORY COURSE MANUAL
"Methods in Yeast Genetics, A laboratory manual", COLD SPRING HARBOR LABORATORY PRESS
HIROBUMI UCHIMIYA: "Manuals for Plant Gene Manipulation", 1990, KODANSHA SCIENTIFIC CO., LTD., pages: 27 - 31
NAGEL ET AL., MICRIBIOL. LETT., vol. 67, 1990, pages 325
GELVIN, S.B. ET AL.: "Plant Molecular Biology Manual", ACADEMIC PRESS PUBLISHERS
SAMBROOK; FRITSCH; MANIATIS: "Molecular Cloning: A Laboratory Manual 2nd Edition", 1989, COLD SPRING HARBOR LABORATORY PRESS
SIEBEN V.J. ET AL., IET NANOBIOTECHNOLOGY, vol. 1, no. 3, June 2007 (2007-06-01), pages 27 - 35
SAMBROOK ET AL.: "Molecular Cloning", 2001, COLD SPRING HARBOUR LABORATORY PRESS
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Hiroshi Kobayashi (JP)
Hiroshi Kobayashi (JP)
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