STILBENE DERIVATIVE AND STILBENE ANALOG DERIVATIVE, AND USE THEREOF

WIPO Patent Application WO/1994/020456

A1

A compound with a 12-lipoxygenase inhibitor activity, represented by general formula (I), a precursor therefor, and a medicine containing the same, wherein R1 represents hydrogen or hydroxy; one of R2 and R3 represents hydrogen, while the other cyano; and Ar represents (a), (b) or (c), wherein R4 represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl or cyano.

HASHIMOTO KOICHI (JP)
YAMADA AKIO (JP)
HAMANO HIROKAZU (JP)
MORI SHIGEHIRO (JP)
MORIUCHI HISAKO (JP)

PCT/JP1994/000390

September 15, 1994

March 10, 1994

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MORINAGA MILK INDUSTRY CO LTD (JP)
HASHIMOTO KOICHI (JP)
YAMADA AKIO (JP)
HAMANO HIROKAZU (JP)
MORI SHIGEHIRO (JP)
MORIUCHI HISAKO (JP)

C07C33/28; C07C255/36; C07C255/37; C07C255/38; C07C255/53; C07D307/54; C07D307/79; C07D333/24; C07D333/28; C07D333/60; (IPC1-7): C07C255/36; A61K31/275; A61K31/34; A61K31/38; C07C255/37; C07C255/38; C07D307/42; C07D307/52; C07D307/81; C07D307/83; C07D333/24; C07D333/28; C07D333/32; C07D333/38; C07D333/60

FR2257272A1

1975-08-08

Journal of the Society of Dyers and Colourists, Vol. 92, No. 1, (1976), H.S. BLAIR et al., "The Effect of the Substrate on the Isomerization of Model Disperse Dyes Based on Stilbene", p. 14-16.
CHEMICAL ABSTRACTS, Vol. 119, No. 21, (1993), M. ANAFI et al., "Tyrphostin-Induced Differentiation of Mouse Erythroleukemia Cells", Refer to Abstract No. 216890p, FEBS Lett., 1993, 330(3), 260-264.
See also references of EP 0640586A4

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