STRAIN EXPRESSING FRSA AND METHOD FOR PRODUCING ETHANOL USING SAME

WIPO Patent Application WO/2014/069823

A1

The present application relates to a strain expressing the FrsA protein, and a method for producing ethanol using the same. The FrsA of the present application has a high PDC enzyme activity for a pyruvate, which is a substrate, and thus can be used in a process for producing ethanol. In addition, an FrsA mutant having improved stability in a host cell can be more effective in producing ethanol due to the increase in stability when the FrsA mutant is overexpressed together with IIAGlc, compared with when using conventional Zymomonas mobilis-derived PDC.

LEE KYUNG-JO (KR)
KIM YU RA (KR)
LEE JUNG KEE (KR)
CHA SUN-SHIN (KR)
LEE KYU-HO (KR)

PCT/KR2013/009311

May 08, 2014

October 18, 2013

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UNIV SOGANG RES FOUNDATION (KR)

C12N1/21; C12N15/53; C12P7/06

KR20110007980A	2011-01-25
KR20120126827A	2012-11-21

LEE, K.-J. ET AL.: "FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.", NATURE CHEMICAL BIOLOGY., vol. 7, July 2011 (2011-07-01), pages 434 - 436
KOO, B.-M. ET AL.: "A Novel Fermentation/Respiration Switch Protein Regulated by Enzyme IIAGIc in Escherichia coli.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 30, 2004, pages 31613 - 31621
DATABASE GENBANK 11 July 2010 (2010-07-11), accession no. M172799

PARK, Weonmee (KR)
박원미 (KR)

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